DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and gef1

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_592943.1 Gene:gef1 / 2542635 PomBaseID:SPAC24H6.09 Length:753 Species:Schizosaccharomyces pombe


Alignment Length:575 Identity:126/575 - (21%)
Similarity:215/575 - (37%) Gaps:146/575 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  1584 CFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVV 1648
            |....|:.| ..|:.....|.|.|.|.|..::|:.                              
pombe    40 CIKRKSINL-SLPSNSYSLSYRQSDDTDGDVSESQ------------------------------ 73

  Fly  1649 ADYIATSG-SNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGL--VPVSVLKPPPG 1710
            ::|..:|| .:..|.::..|    :|.|...|.     ::.|| .....||.  :|.|.:     
pombe    74 SEYRLSSGRRSRASFARALQ----DPQTPNTPP-----VSSQH-RRFFSEGSFNLPNSNM----- 123

  Fly  1711 SHK-HGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSS 1774
            ||. :|..||:|:     |..:..:...:|::.|...||        |..||.:        |||
pombe   124 SHSLNGDSTASNS-----STLTPNRIYGDRNRQDYAQSS--------RYTLPSL--------PSS 167

  Fly  1775 KPLVKKPSEKNLRTPQK-HAEELAEQQNQQPGASPATVLPSSQFPSSTQ---HPGGAGAGDYEPD 1835
                  ||.....|.:| |....:...:::.....:.:..:|...||.:   :..|:...:.|..
pombe   168 ------PSYNCPTTLRKIHTNTSSNGTSRRVSGLGSFMAQNSSETSSNRTSAYLPGSSTDEQEKR 226

  Fly  1836 EEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHES 1900
            ..|.|...|                    .:..|:.::.||  :|....|...:......|..||
pombe   227 SSVTLASMP--------------------SSHSSTASLLSP--LDTTSFSTKLDSTILALETDES 269

  Fly  1901 NSRVDGGGGVENASTNGHGRSHDNNDESH-TAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIV 1964
            .||..........||.|...|.::...|. ::::.:...:|||..:..||::||.||:.||..|.
pombe   270 LSRTISYATTSLPSTPGKRLSKESLAMSEASSINPEYKRIKKRANLIKELVTTEAAYLNDLIAIQ 334

  Fly  1965 NGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKS------------ 2017
            ..|...:...::..|:       ..:.||.:|:.:..:..:|..|..:..:.|            
pombe   335 QSYGLRVKECSALNPV-------DAQTVFGDIESLLTFTVEFHSRLYQAGEGSWRVNLDTQLIDP 392

  Fly  2018 -PADLGPLIKRSATKFALYYT-YCS-------------NKP-LSEYIVSAHYQYFDSIRQKLGHR 2066
             |.:||.:...|.::....|| ||:             .|| .:.:|:..     |.|.||..:.
pombe   393 LPCNLGLIFLESLSEIGQIYTGYCNRQDSVFKIITKWREKPATASWIMEG-----DKIVQKYTNA 452

  Fly  2067 LDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVN 2121
            .||.:|||||:||:.||.||:::||..|..:.  .|.|.|..:||.::.::..:|
pombe   453 WDLGSLIIKPLQRLLKYPLLLQKIIDVTPESS--SERPDLVLSYQLLQELISGIN 505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 126/575 (22%)
SH3_Kalirin_1 1643..1707 CDD:212786 14/66 (21%)
RhoGEF 1945..2121 CDD:459876 53/203 (26%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
gef1NP_592943.1 COG5099 79..>304 CDD:227430 58/288 (20%)
RhoGEF 312..505 CDD:238091 54/206 (26%)
Blue background indicates that the domain is not in the aligned region.

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