DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and rgf3

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	NP_588115.1	Gene:	rgf3 / 2539437	PomBaseID:	SPCC645.06c	Length:	1275	Species:	Schizosaccharomyces pombe

Alignment Length:	425	Identity:	103/425 - (24%)
Similarity:	168/425 - (39%)	Gaps:	100/425 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1243 NSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIK 1307
            |||:..:|....|..|.....|.|:..:...:..||:.||:..  :.||:..|..||.||.|
pombe   427 NSSLEFTSLPGQSSDTWSIFWNISSLNSLPSSLSKREIARQNN--IHELICKESDYVADLNT--- 486

  Fly  1308 CFLEEFRAGKSVPSALIGQEDVI-------------FGNIKEIHHFHQKIFLRELEKYETMPEDV 1359
             ..|.||.|      ::.|:|.|             |||::.|...|.::||.:|...|.:...|
pombe   487 -LAELFRDG------IVQQQDAIVPSNRVADFIQSVFGNVESIRQLHSRLFLPQLIMRERLQGPV 544

  Fly  1360 ----GHCFVTW--ASKFDMYVHYCKNKPTSN---NLLVQHGGSFFEELQ--------RRLEVDHP 1407
                |...:.|  |:| ..|::|.|..|.::   .|..|....|...|.        |||:..|
pombe   545 VSIIGDILLEWIHAAK-SSYINYAKQFPLADETYKLECQRNTYFARWLAACRSDPRCRRLDFQH- 607

  Fly  1408 LPAYLIKPVQRITKYQLLL---------------------KDLLSCCEESHGEIKEGLEVMLNVP 1451
               :|.:|.||:.:|.|.|                     |:|.:.|||....|...||.
pombe   608 ---FLQRPTQRLQRYTLELDTILKHTEQSSWDFQLITQAVKELRATCEECDAVIATVLEA----- 664

  Fly  1452 KKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERR-------VFLFELYLLFA 1509
            .:..|..:..|.:|.: ||:    :.|:|..:.:..:.|:::..:.|       :||.:.||:.|
pombe   665 NRIRDLSYQLLFKNHE-SVN----LELRDPEREFFFEGIVQRRSDSRLDWLDIHLFLLDNYLIMA 724

  Fly  1510 K--EVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIW 1572
            |  :.|.:|..:|....:.:..|:.:......|   |.:.:..:..|......|...||.||.
pombe   725 KARKDKRTNASRYVVSKRPIPLDLLVLSPKMDD---FQLKSNTNKFLGSLAGNLPQESLTTKS-- 784

  Fly  1573 VKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSS 1607
             |:..:|..|..|..|:       .|::.:|..|:
pombe   785 -KRKSKVNLELMFDATA-------EKNNENSMNSA 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015	56/219 (26%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	29/130 (22%)
		PH	1495..1580	CDD:278594	20/93 (22%)
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
rgf3	NP_588115.1	RhoGEF	470..656	CDD:279015	53/200 (27%)
		PH-like	695..850	CDD:302622	28/130 (22%)
		CNH	939..1236	CDD:279162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3601
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030