DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and MCF2L2

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_055893.4 Gene:MCF2L2 / 23101 HGNCID:30319 Length:1114 Species:Homo sapiens


Alignment Length:1204 Identity:255/1204 - (21%)
Similarity:444/1204 - (36%) Gaps:336/1204 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   682 IDKLR---TDVSTDETRLS---QENLEGI-----ERILQ--------QYQRDQQESSVNVCLTTI 727
            ||:.|   :.|....||::   ..||:.|     .|.:|        :|.|::.::.|.:     
Human   104 IDRRRDKWSSVKASLTRIAVAFPGNLQLIFILRPSRFIQRTFTDIGIKYYRNEFKTKVPI----- 163

  Fly   728 SQGEALLQEMRSLE-YADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDAR 791
                .::..:..|. |.|.:.....|..|||..:.|       |...:      ..:..|....:
Human   164 ----IMVNSVSDLHGYIDKSQLTRELGGTLEYRHGQ-------WVNHR------TAIENFALTLK 211

  Fly   792 LLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISM 856
            ..:..::.:...|..|:|.|.....|.|:..|.....::|:....:.:||..||...:.      
Human   212 TTAQMLQTFGSCLATAELPRSMLSTEDLLMSHTRQRDKLQDELKLLGKQGTTLLSCIQE------ 270

  Fly   857 ADATHTAQARI-----------EYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQND---ANQ 907
             .||....:::           |.||..|.|.|............||.|.:||..|::|   |..
Human   271 -PATKCPNSKLNLNQLENVTTMERLLVQLDETEKAFSHFWSEHHLKLNQCLQLQHFEHDFCKAKL 334

  Fly   908 VISWIRNGEAMLVASFVTPNSLQEAEQLRKGH----EQFQIAIEKTHTSAVQVKYRADALINANH 968
            .:..:...:|....   ..:|:...||:.|.|    |:.|..:||....|:.    .|.||.::|
Human   335 ALDNLLEEQAEFTG---IGDSVMHVEQILKEHKKLEEKSQEPLEKAQLLALV----GDQLIQSHH 392

  Fly   969 YDPLSI-----------DEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLERE 1022
            |...:|           |:..:...|||.           ::..|:.|::..::|          
Human   393 YAADAIRPRCVELRHLCDDFINGNKKKWD-----------ILGKSLEFHRQLDKV---------- 436

  Fly  1023 YKREDDWCDGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNC 1087
                ..||:.|         :.|::.....|....:...:|.....|||                
Human   437 ----SQWCEAG---------IYLLASQAVDKCQSREGVDIALNDIATFL---------------- 472

  Fly  1088 EGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLF-----ERSAKQAIEWIHNTGEAYLSSR 1147
             |.||              :|..|..|..  ..:|.|.     :..|::.::.:.:..|.:...:
Human   473 -GTVK--------------EYPLLSPKEF--YNEFELLLTLDAKAKAQKVLQRLDDVQEIFHKRQ 520

  Fly  1148 SNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYK 1212
            .:|:.::                 ||:||.            |:....|.....:||:|      
Human   521 VSLMKLA-----------------AKQTRP------------VQPVAPHPESSPKWVSS------ 550

  Fly  1213 DFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKE-------- 1269
              .....|....|.:.|..|:                      :|..|.:|||..||        
Human   551 --KTSQPSTSVPLARPLRTSE----------------------EPYTETELNSRGKEDDETKFEV 591

  Fly  1270 -------------NKEINEEKR---KSARRKEFIMAELMQTERAYVNDLATCIKCFLE--EFRAG 1316
                         |.|:.::.|   .|.||:  |:.:|::||..|:.::.:.|..::.  :|...
Human   592 KSEEIFESHHERGNPELEQQARLGDLSPRRR--IIRDLLETEEIYIKEIKSIIDGYITPMDFIWL 654

  Fly  1317 KS-VPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNK 1380
            |. :|..|...:|.:||||:|::.||.:.||:||||....||.:.|||:.......:|..|.||.
Human   655 KHLIPDVLQNNKDFLFGNIRELYEFHNRTFLKELEKCAENPELLAHCFLKRKEDLQIYFKYHKNL 719

  Fly  1381 PTSNNLLVQ-HGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSC-----CEESHGE 1439
            |.:..:..: ...::|...||:|:.:.||..||..|.||:.|||:|||.||..     .|...||
Human   720 PRARAIWQECQDCAYFGVCQRQLDHNLPLFKYLKGPSQRLIKYQMLLKGLLDFESPEDMEIDPGE 784

  Fly  1440 I----KEGLEVMLNVPKKAND-----------AMHLSLLENCDVSVD------------KLGEVV 1477
            :    |:|       ||:..|           |:...|:::|:::||            |||:::
Human   785 LGGSAKDG-------PKRTKDSAFSTELQQALAVIEDLIKSCELAVDLAAVTECPDDIGKLGKLL 842

  Fly  1478 LQDAFQAW-------DTKQIIR-KGRERRVFLFELYLLFAKEVKESN----VVKYQFKS--KLMT 1528
            |...|..|       ..|.:|| |..:|:::|||..::|.|...|..    ...|.||.  ||||
Human   843 LHGPFSVWTIHKDRYKMKDLIRFKPSQRQIYLFERGIVFCKIRMEPGDQGLSPHYSFKKTMKLMT 907

  Fly  1529 TDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLP 1593
              :.|.:...|...||.: ..|:.:.   :.:|:|.|.|.:..|..::.:::.|...:......|
Human   908 --LSIRQLGRGSHRKFEI-ASRNGLE---KYILQAASKEIRDCWFSEISKLLMEQQNNIKDQGNP 966

  Fly  1594 K---SPAKHSGSSQRSSRDLDEQLTENDHD---------RCSLASFGSGNT---TDSDNKLGNQE 1643
            :   |.:|.||:.........|:.|.:..|         .||...|.|.:|   .:....:..:.
Human   967 QFEMSTSKGSGAGSGPWIKNMERATTSKEDPASSTGGIKGCSSREFSSMDTFEDCEGAEDMEKES 1031

  Fly  1644 ATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPP 1708
            :...:|....:..|:|...||...:|..| .:.||.:        :.|    :|.....|..:..
Human  1032 SALSLAGLFQSDDSHETCSSKSAFLERGE-SSQGEKE--------ERD----EEETATRSTEEER 1083

  Fly  1709 PGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKA 1742
            .|:   .:|..|.|.::||.|...::.:::..::
Human  1084 AGA---STGRLAPAGATAGFQARALRPRTSAQES 1114

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 23/115 (20%)
SPEC 782..997 CDD:238103 50/243 (21%)
SPEC 897..1119 CDD:238103 44/239 (18%)
SPEC 1125..1226 CDD:197544 13/105 (12%)
RhoGEF 1287..1456 CDD:279015 60/181 (33%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 39/147 (27%)
PH 1495..1580 CDD:278594 24/90 (27%)
SH3_Kalirin_1 1643..1707 CDD:212786 12/63 (19%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
MCF2L2NP_055893.4 SEC14 52..190 CDD:214706 19/94 (20%)
SPEC 321..523 CDD:238103 48/275 (17%)
Spectrin 323..428 25/122 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 530..614 20/125 (16%)
RhoGEF 623..820 CDD:214619 63/203 (31%)
PH-like 827..956 CDD:418428 34/134 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 962..1114 32/167 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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