DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Arhgef16

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_011248543.1 Gene:Arhgef16 / 230972 MGIID:2446219 Length:721 Species:Mus musculus


Alignment Length:731 Identity:142/731 - (19%)
Similarity:263/731 - (35%) Gaps:230/731 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1686 LNPQHDDAAVQEGLV---------------PV-------SVLK---------------PPPGSHK 1713
            ::.:|.|:::.|.|:               |:       |.||               |||.|.:
Mouse     9 MSQRHSDSSLDEKLLEYRFHAELRLDANGNPIPGLPMVRSSLKARANAAFEPDASEPLPPPPSPE 73

  Fly  1714 HGS-------GTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKP 1771
            ...       .|.:.||...|:|:...:..:..|||.. .|..:.:.|..    .:::::...:.
Mouse    74 DEEPPRPIVLSTQSPAALKMGTQQLIPKSLAVASKAKT-KSPARHQSFGA----AVLSKEAARRN 133

  Fly  1772 PSSKPLVKKPS----------------EKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSS 1820
            |.   |...||                .:|||.....|        ...|..|    |||:    
Mouse   134 PQ---LFSAPSFSLDDMDMDMVTTGNLRRNLRNQSYRA--------AMKGPGP----PSSK---- 179

  Fly  1821 TQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAF--AKDAKESSGNMASPGKMDGNP 1883
                     ||       .::|.|.::.:.|.   |..||:.  ||:.|......|..|....:|
Mouse   180 ---------GD-------SVQLGPKLQALAEE---AAQPPSRYPAKNKKTLGRKRAHKGSFKDDP 225

  Fly  1884 --LSEIEEIVKTTTEQHESNSRV----DGGGGVENASTNGHGRSH--------DNNDESHTAVSD 1934
              ..||.|  :.....|||:..:    .|..|.:.|.|....:|:        ...:...:.|.|
Mouse   226 QLYQEIRE--RGLNTSHESDDDILDEPSGPVGTQRADTTIVVKSYRPAQLTWSQLPEVLESGVLD 288

  Fly  1935 K-AAALKKRQCVFAELMSTEEAYVQDLHEIVNGYM--TEINNTNSDIPMPEDLKGGKMKLVFNNI 1996
            . :...:|||....|::::|.:|:..|..:|..::  .|:..|.:..         :...:|:||
Mouse   289 TLSTEERKRQEAIFEILTSEFSYLHSLSILVTEFLQSRELRATMTQT---------EHHHLFSNI 344

  Fly  1997 KDIYEWHRDFF--LRALRNCQKSPADLGPLIKRSAT-KFALYYTYCSNKPLSEYI---VSAHYQY 2055
            .|:....:.||  |......|....|:..:::..|. .|..|..||||:...:..   :|.....
Mouse   345 LDVMSASQKFFEALEQRHKAQVCVEDISDILEDHAQHHFHPYIAYCSNEVYQQRTLQKLSNSNAA 409

  Fly  2056 FDSIRQKLGHR-----LDLSNLIIKPVQRITKYELLIKEIIKATEG-AGLYKEVPMLQEAYQQMK 2114
            |..:.:::..|     |.:.:.:|.|:||:|:..||...:...|:| ...||      .|.|.:|
Mouse   410 FRDVLKEIEKRPACGGLPMISFLILPMQRVTRLPLLTDTLCLKTQGHPERYK------AASQALK 468

  Fly  2115 VVVKTV------------NDMMVVLRSLQDFDGE------ITAQGSLLMQGPMNCVVDAAQKHRE 2161
            .:.|.|            .:.:..|....|| |:      |:|...||.:|.: .:::.:...|:
Mouse   469 AISKLVKQCNEGAHKMERTEQIYTLNMQLDF-GKVKSLPLISASRWLLKRGEL-FLLEESSIFRK 531

  Fly  2162 L------QVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKEL---------GDCR--- 2208
            :      .:|||..:::   :.|.|::.:   :..:.:.||:|:|:::|         |..|   
Mouse   532 IASRPTCYLFLFNDVLV---VTKKKSEES---YLVQDYAQLDHVQVRKLEPSEPLLPGGSSRSSS 590

  Fly  2209 ----FQI---RSTDPKIPEMTIICQAASQE---------NYAGWRDMLNK--------------- 2242
                ||:   .:::.:..::.:...:||..         ....|:.:.||               
Mouse   591 VPYPFQVNLLHNSEGRQEQILLSSDSASDRARWITALTYKERQWQGITNKGELPQVEVTKAYFAK 655

  Fly  2243 ----ILQQQNDLIFML 2254
                |..||.|::.:|
Mouse   656 QADEITLQQADIVLVL 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786 8/57 (14%)
RhoGEF 1945..2122 CDD:279015 43/202 (21%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 33/184 (18%)
Arhgef16XP_011248543.1 RhoGEF 300..478 CDD:366202 43/192 (22%)
PH_ephexin 501..634 CDD:269929 22/139 (16%)
SH3_ARHGEF16_26 645..696 CDD:212871 5/27 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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