DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ARHGEF15

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_011522036.1 Gene:ARHGEF15 / 22899 HGNCID:15590 Length:856 Species:Homo sapiens


Alignment Length:468 Identity:95/468 - (20%)
Similarity:176/468 - (37%) Gaps:112/468 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly  1224 QLEKSLGMSQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEIN-----EEKRKSARR 1283
            |..::..:|::...:|.||:.| .:::||..:.|......|:..:|...:.     :......||
Human   354 QTYRAAVLSEELWGVGEDGSPS-PANAGDAPTFPRPPGPRNTLWQELPAVQASGLLDTLSPQERR 417

  Fly  1284 KEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQE-DVIFGNIKEIHHFHQKIFLR 1347
            .:..:.|::.:|.:|:..|    :...:.|...:::...|..:: ..:|.|::.:....::....
Human   418 MQESLFEVVTSEASYLRSL----RLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQGVSERFLAT 478

  Fly  1348 ELEKYETMPEDVGHCFVTWA---SKFDMYVHYCKN---KPTSNNLLVQHGGSFFEELQR------ 1400
            .|.:..:.|.....|.|..|   ..|.:||.|.:|   :..:.:.|:.....|..||:|      
Human   479 LLSRVRSSPHISDLCDVVHAHAVGPFSVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPK 543

  Fly  1401 --RLEVDHPLPAYLIKPVQRITKYQLLLK--------DLLSCCEESHGEIKEGLEVMLNVPKKAN 1455
              ||    |||::|:.|.||||:.::||:        .|..|.:....:.:||.....|. :||.
Human   544 CERL----PLPSFLLLPFQRITRLRMLLQGHRAGGPVTLPPCPQNILRQTEEGSSRQENA-QKAL 603

  Fly  1456 DAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRV----------------FLFEL 1504
            .|:. .::|.|...|.::.:           |:::||..:..|.                |..||
Human   604 GAVS-KIIERCSAEVGRMKQ-----------TEELIRLTQRLRFHKVKALPLVSWSRRLEFQGEL 656

  Fly  1505 Y--------LLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRS---------- 1551
            .        :|||...:.:.:....|...|:     ||:...|...:...:..||          
Human   657 TELGCRRGGVLFASRPRFTPLCLLLFSDLLL-----ITQPKSGQRLQVLDYAHRSLVQAQQVPDP 716

  Fly  1552 --------PMLSD-----CRIVLKATSLETKQIWVKKL---------REVMQETCFSGTSLTLPK 1594
                    .:||:     ...:|:|:||...|.|:...         .:.:.|.|.....|....
Human   717 SGPPTFRLSLLSNHQGRPTHRLLQASSLSDMQRWLGAFPTPGPLPCSPDTIYEDCDCSQELCSES 781

  Fly  1595 S-PAKHSGSSQRS 1606
            | |||..|.|..|
Human   782 SAPAKTEGRSLES 794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544 1/1 (100%)
RhoGEF 1287..1456 CDD:279015 43/191 (23%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 29/177 (16%)
PH 1495..1580 CDD:278594 22/140 (16%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
ARHGEF15XP_011522036.1 RhoGEF 422..613 CDD:279015 45/200 (23%)
PH_ephexin 637..757 CDD:269929 21/124 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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