Protein Alignment trio and D630003M21Rik

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_808325.2
• Gene: D630003M21Rik / 228846
• MGIID: 3606579
• Length: 1187
• Species: Mus musculus
• Alignment Length: 772
• Identity: 145/772 - (18%)
• Similarity: 262/772 - (33%)
• Gaps: 222/772 - (28%)

  Fly    12 LLQERVVFLTGGRDRRGGPLLCFPATPRRDRLK-----PEDLRRLLSYLISIPSDAAKNLGFTVI 71
            |||..:..|.||||:.|.|||.  .:...|..:     ..::..|||||.|:|....|..|..|:
Mouse   567 LLQSGIACLPGGRDKVGRPLLL--VSTAEDAWEAPWCTTSEVAELLSYLCSVPRLEDKAKGLLVV 629

  Fly    72 IDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASI---SSHKYKFETTTVSIE 133
            ||.| .|.....:.:.|:.:|....|::..|:::       .::|||   |....:.|..| |::
Mouse   630 IDAR-KGTQRPGLVSALQGIQALAPASVSKVLLL-------GEKASIPQLSVLPAQVEVLT-SLK 685

  Fly   134 SLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPL 198
            :|...|:..||....||...|.|.:|......::.|.......:..:....::..:.:....|..
Mouse   686 ALRNHVDPSQLPEALEGPFPYHHSEWVQFFQKLDPFLTDLRQASSLLQASIQEFEKGEPPGGVQE 750

  Fly   199 ARHAIDHHNEMRKKITKLP-IEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQS 262
            |...:....|:.:.:.:.| :..|..:|...||.:...|         ||   :::.|......:
Mouse   751 ATRCLSKSKELMETVLRDPGLLALQREGGTTLASLQQEA---------SG---LNANPDVRSHLT 803

  Fly   263 QPSQQSRSVGGN-PDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            :.:.....|.|. .|:..|.|:.||::||               :|:|..      .|....::.
Mouse   804 EAAALYNLVDGQLHDLVTASNQLLRRLEL---------------RVRLGH------LETAIHQVS 847

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            ||:....   ..|...:...:..|::::..|.:|.          |..|.|||:
Mouse   848 DWMAGEG---SQSLQALAPVHVCAETVEKVHAEFE----------DFFLQVAAQ----------- 888

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQP------LPSD 450
                          :..|||......||........|.....:|::|:..||.|.      :.::
Mouse   889 --------------YRQGLDLSKQAAQLGAAEEGAGEMGLPDLAAFASTQQAFQARLTHFYMAAE 939

  Fly   451 IQ--SLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSF 513
            .|  .|||.:..|:     ..:..:..|...:.||.||                         |.
Mouse   940 RQRTDLETLLHLHR-----FRRKMSRFHMDCQNLLTQL-------------------------SL 974

  Fly   514 NKYERQNPAADYSEGASHVLAVIH-QILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWL 577
            .|..:.:|...           :| ::..:.:.|.:::..|:|     ||::|
Mouse   975 GKAVKASPGDQ-----------LHLRLHCYLKRLASEFQTEKL-----LAMKL------------ 1011

  Fly   578 KNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYS 642
                :|......|:|:     .|::.        ||..:...|.||..|.......|....::..
Mouse  1012 ----QVASLSRPGLGQ-----EVWEE--------AQERHQEIQSLLRKALAYCPCPEVPATQVAL 1059

  Fly   643 VARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERI 707
            :.|...:..|....|                              :|.:...|..|::| .::.:
Mouse  1060 IDRSRPVAKGQGLPR------------------------------EVGSKWDRSLQDSL-AVDHV 1093

  Fly   708 LQQYQRDQQESSVNVCLTTIS-----QGEALLQEMRSLEYADNTGSIAALEATLEKL 759
            .:..:..|.|.|.|:....:|     .|:.  :|:|        |:....:.|||:|
Mouse  1094 FKSQRTPQGEQSRNMWAGLLSPEPGQSGDT--EEVR--------GTPKLPDPTLERL 1140

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	43/146 (29%)
		SPEC	314..>468	CDD:238103	28/161 (17%)
		SPEC	563..778	CDD:238103	32/202 (16%)
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
D630003M21Rik	NP_808325.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..405
		PHA03247	<303..646	CDD:223021	27/81 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	419..451
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	511..551
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1095..1134		9/48 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1148..1187