DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and D630003M21Rik

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	NP_808325.2	Gene:	D630003M21Rik / 228846	MGIID:	3606579	Length:	1187	Species:	Mus musculus

Alignment Length:	772	Identity:	145/772 - (18%)
Similarity:	262/772 - (33%)	Gaps:	222/772 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLQERVVFLTGGRDRRGGPLLCFPATPRRDRLK-----PEDLRRLLSYLISIPSDAAKNLGFTVI 71
            |||..:..|.||||:.|.|||.  .:...|..:     ..::..|||||.|:|....|..|..|:
Mouse   567 LLQSGIACLPGGRDKVGRPLLL--VSTAEDAWEAPWCTTSEVAELLSYLCSVPRLEDKAKGLLVV 629

  Fly    72 IDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASI---SSHKYKFETTTVSIE 133
            ||.| .|.....:.:.|:.:|....|::..|:::       .::|||   |....:.|..| |::
Mouse   630 IDAR-KGTQRPGLVSALQGIQALAPASVSKVLLL-------GEKASIPQLSVLPAQVEVLT-SLK 685

  Fly   134 SLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDVPL 198
            :|...|:..||....||...|.|.:|......::.|.......:..:....::..:.:....|..
Mouse   686 ALRNHVDPSQLPEALEGPFPYHHSEWVQFFQKLDPFLTDLRQASSLLQASIQEFEKGEPPGGVQE 750

  Fly   199 ARHAIDHHNEMRKKITKLP-IEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQS 262
            |...:....|:.:.:.:.| :..|..:|...||.:...|         ||   :::.|......:
Mouse   751 ATRCLSKSKELMETVLRDPGLLALQREGGTTLASLQQEA---------SG---LNANPDVRSHLT 803

  Fly   263 QPSQQSRSVGGN-PDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            :.:.....|.|. .|:..|.|:.||::||               :|:|..      .|....::.
Mouse   804 EAAALYNLVDGQLHDLVTASNQLLRRLEL---------------RVRLGH------LETAIHQVS 847

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            ||:....   ..|...:...:..|::::..|.:|.          |..|.|||:
Mouse   848 DWMAGEG---SQSLQALAPVHVCAETVEKVHAEFE----------DFFLQVAAQ----------- 888

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQP------LPSD 450
                          :..|||......||........|.....:|::|:..||.|.      :.::
Mouse   889 --------------YRQGLDLSKQAAQLGAAEEGAGEMGLPDLAAFASTQQAFQARLTHFYMAAE 939

  Fly   451 IQ--SLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSF 513
            .|  .|||.:..|:     ..:..:..|...:.||.||                         |.
Mouse   940 RQRTDLETLLHLHR-----FRRKMSRFHMDCQNLLTQL-------------------------SL 974

  Fly   514 NKYERQNPAADYSEGASHVLAVIH-QILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWL 577
            .|..:.:|...           :| ::..:.:.|.:::..|:|     ||::|
Mouse   975 GKAVKASPGDQ-----------LHLRLHCYLKRLASEFQTEKL-----LAMKL------------ 1011

  Fly   578 KNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYS 642
                :|......|:|:     .|::.        ||..:...|.||..|.......|....::..
Mouse  1012 ----QVASLSRPGLGQ-----EVWEE--------AQERHQEIQSLLRKALAYCPCPEVPATQVAL 1059

  Fly   643 VARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERI 707
            :.|...:..|....|                              :|.:...|..|::| .::.:
Mouse  1060 IDRSRPVAKGQGLPR------------------------------EVGSKWDRSLQDSL-AVDHV 1093

  Fly   708 LQQYQRDQQESSVNVCLTTIS-----QGEALLQEMRSLEYADNTGSIAALEATLEKL 759
            .:..:..|.|.|.|:....:|     .|:.  :|:|        |:....:.|||:|
Mouse  1094 FKSQRTPQGEQSRNMWAGLLSPEPGQSGDT--EEVR--------GTPKLPDPTLERL 1140

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	43/146 (29%)
		SPEC	314..>468	CDD:238103	28/161 (17%)
		SPEC	563..778	CDD:238103	32/202 (16%)
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		PH	1495..1580	CDD:278594
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
D630003M21Rik	NP_808325.2	PRK10475	<276..357	CDD:236698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..405
		PHA03247	<303..646	CDD:223021	27/81 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	419..451
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1095..1134		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1148..1187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4240
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810