DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and Vav2

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_006497917.1 Gene:Vav2 / 22325 MGIID:102718 Length:878 Species:Mus musculus


Alignment Length:987 Identity:192/987 - (19%)
Similarity:329/987 - (33%) Gaps:321/987 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly  1071 LKYANRSQQCYQYKGNCEGHVKSKL----DKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQ 1131
            ||..|...|..|:.  |..::::.|    ||...:.:::.|             .|.||:     
Mouse    57 LKDINFRPQMSQFL--CLKNIRTFLKVCHDKFGLRNSELFD-------------PFDLFD----- 101

  Fly  1132 AIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAH 1196
                :.:.|:. :|:.|.|...|..:::|:....:|  .||:...:..:.|.:|||.     |..
Mouse   102 ----VRDFGKV-ISAVSRLSLHSIAQSKGIRPFPSE--ETAENDDDVYRSLEELADE-----HDL 154

  Fly  1197 ASDIKQWVASVDQR---YKDF-----SNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDR 1253
            ..||...|...|:.   |:|.     ...|..|.::    :||::                    
Mouse   155 GEDIYDCVPCEDEGDDIYEDIIKVEVQQPMIRYMQK----MGMTE-------------------- 195

  Fly  1254 HSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFR---A 1315
                                 ::||...      :.|:.:||..|...|....|.::...|   :
Mouse   196 ---------------------DDKRSCC------LLEIQETEAKYYRTLEDIEKNYMGPLRLVLS 233

  Fly  1316 GKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELE-KYETMPEDVGHCFVTWASKFDMYVHYCKN 1379
            ...:.:..|..||:|     ::||    .|||.:: ........:...|:.:..:..:|..||.:
Mouse   234 PADMAAVFINLEDLI-----KVHH----SFLRAIDVSMMAGGSTLAKVFLEFKERLLIYGEYCSH 289

  Fly  1380 ----KPTSNNLLVQHGGSFFEELQRRLEV--------DHPLPAYLIKPVQRITKYQLLLKDLLSC 1432
                :.|.|.||...     |:.::::|.        ...|...|:.|:||:.||.||||:|||.
Mouse   290 MEHAQSTLNQLLASR-----EDFRQKVEECTLRVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSH 349

  Fly  1433 CEE--SHGEIKEGLEVM------LNVPKKANDAM-----HLSLLENCDVSVDKLGEVVLQDAFQA 1484
            ..:  ...::||.||.|      :|..|:..:.:     ....:||..|.:::.|...:....:.
Mouse   350 SADRPERQQLKEALEAMQDLAMYINEVKRDKETLKKISEFQCSIENLQVKLEEFGRPKIDGELKV 414

  Fly  1485 WD----TKQIIRKGRERRVFLFELYLLFAK------EVKESNVVKYQFKSKLMTTDMGITEHIEG 1539
            ..    |||      :|.:|||:..::..|      |:||  |::..|..  ||.|....:.|:.
Mouse   415 RSIVNHTKQ------DRYLFLFDKVVIVCKRKGYSYELKE--VIELLFHK--MTDDPMHNKDIKK 469

  Fly  1540 DETKFAVWT---------GRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKS 1595
            ...|  :|:         |:......|:      :.:.|:.|:::....|       :::...|:
Mouse   470 SHGK--MWSYGFYLIHLQGKQGFQFFCK------TEDMKRKWMEQFEMAM-------SNIKPDKA 519

  Fly  1596 PAKHSGSSQRSSRD--------------------LDEQLTENDHDRC-------------SLASF 1627
            .|.|. |.|..:.|                    |..:.....|..|             .:.:.
Mouse   520 NANHH-SFQMYTFDKTTNCKACKMFLRGTFYQGYLCTRCGVGAHKECLEVIPPCKMSSPADVDAP 583

  Fly  1628 GSG---NTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQ 1689
            |:|   ......|..||.          |..|...|:...|..:|::.    |:||      :|.
Mouse   584 GAGPGPKMVAVQNYHGNP----------APPGKPVLTFQTGDVIELLR----GDPD------SPW 628

  Fly  1690 HDDAAVQ---EGLVPVSVLKPPPGSHKHGSGTAANAASS-------AGSQKSDMQDQSNRSKADA 1744
            .:...||   .|..|.|.:||.|...:..:|...:....       ||:.:....|...:|.|..
Mouse   629 WEGRLVQTRKSGYFPSSSVKPCPVDGRPPTGRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASG 693

  Fly  1745 LSSSTKRRGFSGR--------------------NWLPLMNRKGTDKPPSSKPLVK-------KPS 1782
            .....:|...:.|                    :|:.:...|   |..|...||:       |.|
Mouse   694 TYLIRERPAEAERFAISIKFNDEVKHIKVVEKDSWIHITEAK---KFESLLELVEYYQCHSLKES 755

  Fly  1783 EKNLRT----PQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELP 1843
            .|.|.|    |.|..|....:.:.:..||.|:      :..|...|.|.......|.        
Mouse   756 FKQLDTTLKFPYKSRERTTSRASSRSPASCAS------YNFSFLSPQGLSFAPQAPS-------- 806

  Fly  1844 PPMKPIQEPHLIANGPPAF---AKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVD 1905
            .|...:..|.:|......:   |:|.:|.|             |.| .::||.       .||:.
Mouse   807 APFWSVFTPRVIGTAVARYNFAARDMRELS-------------LRE-GDVVKI-------YSRIG 850

  Fly  1906 GGGGVENASTNG 1917
            |..|.....|||
Mouse   851 GDQGWWKGETNG 862

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103 10/51 (20%)
SPEC 1125..1226 CDD:197544 23/108 (21%)
RhoGEF 1287..1455 CDD:459876 47/191 (25%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 28/140 (20%)
SH3_Kalirin_1 1643..1707 CDD:212786 14/66 (21%)
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Vav2XP_006497917.1 CH_VAV2 2..120 CDD:409112 17/87 (20%)
RhoGEF 202..374 CDD:459876 45/191 (24%)
PH_Vav 389..516 CDD:269930 28/151 (19%)
C1_VAV2 519..576 CDD:410418 8/57 (14%)
SH3_VAV2_1 590..649 CDD:212913 17/78 (22%)
SH2_Vav2 667..769 CDD:198269 19/104 (18%)
SH3_VAV2_2 819..876 CDD:212910 15/65 (23%)
Blue background indicates that the domain is not in the aligned region.

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