Protein Alignment trio and Vav1

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_035821.3
• Gene: Vav1 / 22324
• MGIID: 98923
• Length: 845
• Species: Mus musculus
• Alignment Length: 365
• Identity: 81/365 - (22%)
• Similarity: 148/365 - (40%)
• Gaps: 59/365 - (16%)

  Fly  1868 ESSGNMASPGK----MDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDES 1928
            ::.|.|..|.:    .|.:..|.:.:.:..|.|:.|     |....|||....|.....|.....
Mouse   122 QNKGIMPFPTEDSALNDEDIYSGLSDQIDDTAEEDE-----DLYDCVENEEAEGDEIYEDLMRLE 181

  Fly  1929 HTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVF 1993
            ......|.....||.|...|:..|||.|...|..|...:|.         |:...||...|:.:|
Mouse   182 SVPTPPKMTEYDKRCCCLREIQQTEEKYTDTLGSIQQHFMK---------PLQRFLKPQDMETIF 237

  Fly  1994 NNIKDIYEWHRDFFLRALRNCQKSP--ADLGPLIKRSATKFALYYTYCS-----NKPLSEYIVSA 2051
            .||::::..| ..||:.|::....|  ..|..:..:...:|.:|..|||     :|.|.: :.:|
Mouse   238 VNIEELFSVH-THFLKELKDALAGPGATTLYQVFIKYKERFLVYGRYCSQVESASKHLDQ-VATA 300

  Fly  2052 HYQYFDSIRQKL--------GHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQE 2108
            .    :.::.||        ..|..|.:|::.|:||:.||.||::|::|.|:.|   .|...|:.
Mouse   301 R----EDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQDA---TEKENLRL 358

  Fly  2109 AYQQMKVVVKTVNDMM---VVLR-------SLQDFDGEITAQGSLLMQGPMNCVVDAAQKHRELQ 2163
            |...|:.:.:.||::.   ..||       |:::.|..:...|...:.|.:.......:...:..
Mouse   359 ALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLANYGRPKIDGELKITSVERRSKTDRY 423

  Fly  2164 VFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKE 2203
            .||..:.::..     |.:..|  :..::.:.|:..|:::
Mouse   424 AFLLDKALLIC-----KRRGDS--YDLKASVNLHSFQVRD 456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876	49/190 (26%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	9/74 (12%)
Vav1	NP_035821.3	CH_VAV1	2..121	CDD:409111
		RhoGEF	195..371	CDD:238091	51/193 (26%)
		PH_Vav	385..508	CDD:269930	10/79 (13%)
		C1_VAV1	510..566	CDD:410417
		SH3_VAV1_1	596..658	CDD:212912
		SH2_Vav1	665..767	CDD:198268
		SH3_VAV1_2	786..839	CDD:212909