Protein Alignment trio and Plekhg1

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_006512502.1
• Gene: Plekhg1 / 213783
• MGIID: 2676551
• Length: 1487
• Species: Mus musculus
• Alignment Length: 1258
• Identity: 251/1258 - (19%)
• Similarity: 437/1258 - (34%)
• Gaps: 365/1258 - (29%)

  Fly  1152 GISKEETEGLLKEHNEF------------RSTAKETRERVKLLIQLADS--LVEKGHAHASDIKQ 1202
            ||...||:|  ..|.:.            |:||:.:.......::|:||  .:..|...:|
Mouse    57 GIRIHETDG--HRHLQLDVPSAVSLVPDPRTTAEPSESPEPKTMELSDSDRPISFGSTSSS---- 115

  Fly  1203 WVASVDQRYKDFSNRMDSYCE------QLEKSLGMSQQQLL---------LGSDGNSSISSSSGD 1252
              ||....:..|.:||.....      ..:|..|..:.:|:         |..|..:...:.:|.
Mouse   116 --ASSRDSHGSFGSRMTLVSNSHLGLFHQDKEAGAIKLELVPARPFSSSELQRDKPAGPQNMNGV 178

  Fly  1253 RHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGK 1317
            ....|....::::|.......:..........:.::.|:::|||.||.||.:.::.:||..|...
Mouse   179 SEKQPRTPWRMDTSGTPQTTADSATSPKLLYVDRVVQEILETERTYVQDLKSIVEGYLECIRDQT 243

  Fly  1318 SVPSALIGQED--VIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNK 1380
            .:|   :..||  .:||||::|:||:.:: |::||..|..|..:..|||:.:.:|.:|..||.|.
Mouse   244 KLP---LVTEDRAALFGNIQDIYHFNSEL-LQDLENCENDPVAIAECFVSKSEEFHIYTQYCTNY 304

  Fly  1381 PTS---------NNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDL---LSCC 1433
            |.|         |.:|.:    ||.|.|..|....||.:||:||||||.||.|||.::   |...
Mouse   305 PRSVAVLTECMRNKILTK----FFRERQETLRHSLPLGSYLLKPVQRILKYHLLLHEIENHLDKA 365

  Fly  1434 EESHGEIKEGLEVMLNVPKKAND-------AMHL----SLLENCD-VSVDKLGEVVLQDAFQAWD 1486
            .|.:..:.:.::.|..|....||       |:.|    |||.|.: ..:...||:||:..|:...
Mouse   366 TEGYDVVLDAIDTMQRVAWHINDMKRKHEHAVRLQEIQSLLTNWEGPDLTSYGELVLEGTFRIQK 430

  Fly  1487 TKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRS 1551
            .|      :||.:||.:..||..|:..::    :.:|:.::..::.:.|.|..:...|:|:..::
Mouse   431 AK------KERTLFLLDQLLLITKKRDDT----FTYKAHILCGNLMLVEVIPKEPLSFSVFHYKN 485

  Fly  1552 PMLSDCRIVLKATSLETKQIWVKKLREVMQET--------------------------CFSGT-S 1589
            |.|..   .::|.|.:.|::||..|:.::.|.                          |:|.. .
Mouse   486 PKLQH---TVQAKSQQDKRLWVLHLKRLILENHAAAAKIPAKAKQAILEMDAIHYPGFCYSPEGE 547

  Fly  1590 LTLPKSPAKH-----SGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVA 1649
            :..|...|.|     |..|.||.:.|....|..|..:.|.....|..|:....:...|..:..|.
Mouse   548 MKTPCGSAPHRLRRKSEPSSRSHKVLKTSETSQDIQKVSREESPSQLTSAVPAQRNCQPGSAAVI 612

  Fly  1650 DYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKH 1714
            :.:...|.             |..|.....    :|   |..|..:::.|.|
Mouse   613 NMLRGGGG-------------VRSPWTDHH----IR---QRTDHHIRQPLFP------------- 644

  Fly  1715 GSGTAANAASSAGSQKSDMQDQSNR------SKADALSSSTKRRGFSGR--NW-LPLMNRKGTDK 1770
                     |....|:::..|...:      |.:|..|:.......|.|  :| |.|:  :.|:.
Mouse   645 ---------SRRSPQENEDDDDDYQMFVPSFSSSDLNSTRLCEENASSRPCSWHLGLI--EPTEI 698

  Fly  1771 PPSSKPLVKKPS---EKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDY 1832
            ..|...:|::.|   |.|...|:....:..:.|          ..|..|..:|.:..|..|...|
Mouse   699 SSSGHRIVRRASSAGESNACPPEVRIRDCDDSQ----------YCPGRQLQNSPRPGGERGMTPY 753

  Fly  1833 EPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAK-------ESSGNMASPGKMDGNPLSEIE-- 1888
            ....|:.::        ...|:..|   ...:|.|       |:..:.:.|.:....|.|..|
Mouse   754 GSSVELTID--------DIDHVYDN---ISFEDLKLMVAKRDETECSFSKPSRDSVRPKSTPELA 807

  Fly  1889 ----EIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAEL 1949
                ::..:|:..|   ||.:.|.|.:.|||
Mouse   808 FSKRQVSHSTSSLH---SRKEAGLGGQEAST---------------------------------- 835

  Fly  1950 MSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFF--LRALR 2012
                    |.:||    :.....|....|.:|:.   ..|.|   |...:::..|..|  |.|..
Mouse   836 --------QSVHE----HQEVEENIYDTIGLPDP---PSMNL---NHSSLHQPKRSTFLGLEADF 882

  Fly  2013 NCQKSPADLGPLIKRSATKFA------------------LYYTYCSNKPLSEYIVSAHYQYFDSI 2059
            .|..|   |.|.:.:.:.:|:                  ||.:...|.|:::..:|
Mouse   883 ACCDS---LRPFVSQDSLQFSEDDISYHQGPSDTEYLSLLYDSPRCNLPIADKALS--------- 935

  Fly  2060 RQKLGHRL-----DLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKT 2119
             .||...:     ||.|.|.|...:.....|....:.|......||                |.:
Mouse   936 -DKLSEEVDEIWNDLENYIKKNEDKSRDRLLAAFPVSKDDAPERLY----------------VDS 983

  Fly  2120 VNDM---------MVVLRSLQDFDGEITAQGSLLMQGPMNCVVDAAQKHRELQVFLFQQIIIFAD 2175
            .:::         |:.|.:.|.|  .:..:..::.....||.:|......|.......|:.:.:|
Mouse   984 THELGRDTGHATSMLALPTSQTF--LLPGKSRVVRASRANCSLDNDIISTEGSFLSLNQLSLASD 1046

  Fly  2176 IEKTKNQYASPIFKYRSHIQLNHMQMKELGDCRFQIRSTDPKIPEMTIICQAASQENYAGWRDML 2240
            .....|.|                   :|.:|  .:..|||:.|:..:
Mouse  1047 GPPVDNPY-------------------DLANC--SLPQTDPENPDPGM----------------- 1073

  Fly  2241 NKILQQQNDLIFMLSNPLSTKNK 2263
             ::..:....:||::...|.|.|
Mouse  1074 -EVTDKTKSRVFMMARQYSQKIK 1095

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544	19/93 (20%)
		RhoGEF	1287..1455	CDD:459876	62/181 (34%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	30/148 (20%)
		SH3_Kalirin_1	1643..1707	CDD:212786	9/63 (14%)
		RhoGEF	1945..2121	CDD:459876	35/200 (18%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	18/129 (14%)
Plekhg1	XP_006512502.1	RhoGEF	213..387	CDD:459876	62/181 (34%)
		PH_PLEKHG1_G2_G3	369..514	CDD:270063	36/157 (23%)