DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ephx-1

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_494706.2 Gene:ephx-1 / 173742 WormBaseID:WBGene00019487 Length:1159 Species:Caenorhabditis elegans


Alignment Length:763 Identity:145/763 - (19%)
Similarity:270/763 - (35%) Gaps:230/763 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly  1569 KQIWVKKLREVMQETCFSGT--------SLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLA 1625
            ::|:.:...|:::|..|...        |.||.::|   ..|.:.||.:|::........:.:| 
 Worm   334 EEIFDEAEEELLEEQRFQKVPEIKERFLSSTLQRNP---KSSKRMSSMELEKLFRFKSELQLNL- 394

  Fly  1626 SFGSGNTTDSDNKLGNQEA-----TWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVR 1685
               |...:....|:|:::|     ..|..|.:.|..|:.:|.|.                 |:.:
 Worm   395 ---SKKVSQLRQKVGDKQAKRRSKCHVSVDLLDTDFSSMMSKSS-----------------CVDK 439

  Fly  1686 LNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAAN-----AASSAGSQKSDMQDQSNRSKADAL 1745
              |..||                  .|.:|...:::     ......|....:::|.|::..|.:
 Worm   440 --PFQDD------------------DHIYGDDWSSDDDDIYHDDRRSSMYRQLEEQLNKAFPDYV 484

  Fly  1746 SSSTKRRGFSGRNWL--PLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASP 1808
            ..|.....:...:.|  |:        |..|..:|...:||.:..|             ..|..|
 Worm   485 CRSQLSSDYESADILVDPI--------PARSSEVVMSDTEKYVARP-------------AVGHLP 528

  Fly  1809 ATVLPSSQFPSSTQHPGGAGAGDYEPDEE-----VGLELPPPMKPIQEPHLIANGPPAFAKD--- 1865
               |..|..|:|.:    |...:..||||     ....:.|...|:.:.:::.  ..|.|.|   
 Worm   529 ---LDDSWTPTSAE----AIQDEPSPDEEEYKRQYTCRMVPNEGPLYQHYMLE--AVAVADDEVK 584

  Fly  1866 -----AKESSGNMASPGKMDGNPLSEIEEIV--KTTTEQHESNSRVDGGGGVENASTNGHGRSHD 1923
                 .||....:         |.:.:.|:|  |..| :.||:...|.|.|.:.::|:....:.:
 Worm   585 IPLEEVKEEPVEL---------PAAVVHEVVALKPAT-RRESSISSDSGRGADCSTTSASALTSN 639

  Fly  1924 NNDESHTAVSD----------------KAAAL--------KKRQCVFAELMSTEEAYVQDLHEIV 1964
            .:......|..                :||.|        |.||..:.|::::|.:|::.|:.::
 Worm   640 TSMRRDRLVGTSNFGSQRSLWCELPEVRAAGLLEKLDDECKLRQEAYFEVITSEASYLRSLNVLI 704

  Fly  1965 NGYMT--EINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNC-QKSPADLGPLIK 2026
            ..:|.  ::..:.|.:.:   |.....|.:|:||            .|:|:| ::...||...::
 Worm   705 THFMASPQMLGSKSALSV---LSDSDRKHLFSNI------------FAVRDCSERLLCDLETRLE 754

  Fly  2027 RSA--------------TKFALYYTYCSN-----------KPLSEYIVSAHYQYFDSIRQKLGHR 2066
            .:.              ..|.:|..||||           |..:...:|| .|..:..:|..|  
 Worm   755 ENLILDDICDILSDHFDKHFEVYIKYCSNQVYQDRTLRRLKTENPGFLSA-VQRLEENKQCQG-- 816

  Fly  2067 LDLSNLIIKPVQRITKYELLIKEII-KATEGAGLYKEVPMLQEAYQQMKVVVKTVND---MMVVL 2127
            ||:.:.::.|:||:|:|.||:..|: :.|.....||..   .:|......||:..|:   .|...
 Worm   817 LDMRSFLMLPMQRVTRYPLLLYAILDRITTTDDRYKTA---TDALTSSNRVVRDCNEGARRMERT 878

  Fly  2128 RSLQDFDGEITAQGSLLMQGPM---------------------NCVVDAAQKHRELQVFLFQQII 2171
            ..|.|.|..:..:.:.|.:.|:                     :.::.:.||.|.|.||||..:|
 Worm   879 EQLLDIDRRLIYKDADLKRIPLVSNSRYLVKKGVLTQLVERRSSNILQSRQKARTLHVFLFSDMI 943

  Fly  2172 IFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGDCRFQIRSTDPKIP 2219
            :... :|....:....:..|..:.:.            .|...:||||
 Worm   944 MITK-KKLNGTFVCKDYAARRFVDMQ------------PIEPDNPKIP 978

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 3/14 (21%)
PH 1495..1580 CDD:278594 2/10 (20%)
SH3_Kalirin_1 1643..1707 CDD:212786 11/68 (16%)
RhoGEF 1945..2122 CDD:279015 44/205 (21%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 21/111 (19%)
ephx-1NP_494706.2 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3601
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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