Protein Alignment trio and F55D12.2

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_001250623.1
• Gene: F55D12.2 / 172558
• WormBaseID: WBGene00010111
• Length: 712
• Species: Caenorhabditis elegans
• Alignment Length: 907
• Identity: 189/907 - (20%)
• Similarity: 324/907 - (35%)
• Gaps: 268/907 - (29%)

  Fly     1 MDGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLI-SIPSDAAK 64
            |:.|:.|..:.   :|:.|:.||.||.|..||.. :|.:......|:|..||:.|. ::|....
 Worm     1 MNWQKQRQHVL---DRLAFVPGGTDREGNALLVI-STSQVQECSYENLVSLLALLSDTLPPSTL- 60

  Fly    65 NLGFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRAS----ISSHKYKF 125
               |||::|.|...  ...:|..|:..|:.....:..|:||:|:.|..:|:.:    :|.  |..
 Worm    61 ---FTVLLDTRHIQ--LKQLKFYLRACQQALYKKVRQVLIIQPEKFLDQQKINFDLIVSG--YTL 118

  Fly   126 ETTTVSIESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRN 190
            :|..||:..|:|.|:.:||...|.|...||...|...|:.|:.  ||                 |
 Worm   119 KTVLVSMHKLSKFVDVNQLPEQFGGTLGYDPDSWLSKRIEIKK--WQ-----------------N 164

  Fly   191 DFAE-DVPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSG 254
            ...| |...::|::|...::.:.||||       |..|.:....|
 Worm   165 YLVEVDADSSKHSLDDDQKLEEFITKL-------QSTKRIEDEYA-------------------- 202

  Fly   255 PSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFE 319
                                   |..:.|::|.::|......|..::..|.....|
 Worm   203 -----------------------SNILKKSVRDVKLKEEENSKEGLIKDHTAGVSD--------- 235

  Fly   320 QDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIES 384
                 ..|||..:.:.:..|..::..|...|:||..:|::....:..:.....::..:|.||:.:
 Worm   236 -----FLDWIEGSGEKWLNSLCQVADNVDEAESLVKQHEELTNKTKEIEEQSHQLAEMATRLMAA 295

  Fly   385 QHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPS 449
            ....|..::...:::....:.||..::.:|.....:..|..|..::
 Worm   296 CPQVAIVLQKTREQIRDVAEHFAYRVEAQTQFAVSNRTFREKVAEF------------------- 341

  Fly   450 DIQSLETAIRTHQSLYEAMC-------QAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKN 507
                    |:....:.|.:|       :...|:.||.|    :||.||                |
 Worm   342 --------IKKSDLMLEKVCAEDGASVKTVEELTSTKK----ELDDLV----------------N 378

  Fly   508 SNNGSF--------------NKYERQNPAADYSEGASHV---LAVIHQILSHHRTLEAKWHQERL 555
            |.|.||              .:|....||.::   .||:   |..|.|..:.|..|.:   .:||
 Worm   379 SMNVSFETAMDAGEETVAKARQYSEVLPAEEF---VSHIGSSLTYISQRQNRHNELAS---VKRL 437

  Fly   556 RLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHK-----------ARVYQTSHDNFE 609
            ...|.|.|.....|..|.:.||   ||:   |.|     .||           .:..:....|.:
 Worm   438 EQQQHLQLMTTYGDCDQAIKWL---GEL---KET-----LHKEYSLSDIDEDAVKNLRNDRQNLD 491

  Fly   610 NVAQNTYSNAQKLLAAADELARSG--EADPNE----IYSVARELELQVGSFAERVEQRRRRLDMA 668
            ..|.:||...::||:.|....||.  |:..:|    :.:..:||.|       .::...:||.:.
 Worm   492 RTAVSTYQYGKQLLSMAKNSERSAMKESSTDERKEKLETAWKELNL-------AIQNNEQRLKVV 549

  Fly   669 VIFY-TH----------EKDVTAWIDKLRTD-------VSTDETRLSQ--ENLEGIERILQ-QYQ 712
            ..|. ||          ||.:.   ::||..       :||:..||..  |.|..|..:|. |..
 Worm   550 ESFMATHRQMMERVNEIEKSLR---ERLRVSGKLNSIVLSTERKRLKNDIEELSNIGNMLSAQIN 611

  Fly   713 RDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRA 777
            .|.        .||:...:..::::     :|....:...:..:|.|   .:|.||..|:...:.
 Worm   612 ADH--------ATTLQDRQTAVKQI-----SDKINEVMTAQRRMESL---IIEEEEAGSSSSGKE 660

  Fly   778 DLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEI----QNATY 835
            |     ::..|.||.||...|   ||  ..|:|..:.:|.:|:.. ||.:...    :|.:|
 Worm   661 D-----KHSSRKARPLSKVPE---EE--GGDVSPVFPRAVRLLET-NEGIAPAIRLSKNESY 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	42/143 (29%)
		SPEC	314..>468	CDD:238103	20/153 (13%)
		SPEC	563..778	CDD:238103	53/252 (21%)
		SPEC	782..997	CDD:238103	16/58 (28%)
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
F55D12.2	NP_001250623.1	SEC14	11..144	CDD:469559	41/144 (28%)
		rad50	<181..604	CDD:129694	103/560 (18%)
		SPEC	233..403	CDD:413338	36/230 (16%)