DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trio and F55D12.2

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	NP_001250623.1	Gene:	F55D12.2 / 172558	WormBaseID:	WBGene00010111	Length:	712	Species:	Caenorhabditis elegans

Alignment Length:	907	Identity:	189/907 - (20%)
Similarity:	324/907 - (35%)	Gaps:	268/907 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLI-SIPSDAAK 64
            |:.|:.|..:.   :|:.|:.||.||.|..||.. :|.:......|:|..||:.|. ::|....
Worm     1 MNWQKQRQHVL---DRLAFVPGGTDREGNALLVI-STSQVQECSYENLVSLLALLSDTLPPSTL- 60

  Fly    65 NLGFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRAS----ISSHKYKF 125
               |||::|.|...  ...:|..|:..|:.....:..|:||:|:.|..:|:.:    :|.  |..
Worm    61 ---FTVLLDTRHIQ--LKQLKFYLRACQQALYKKVRQVLIIQPEKFLDQQKINFDLIVSG--YTL 118

  Fly   126 ETTTVSIESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRN 190
            :|..||:..|:|.|:.:||...|.|...||...|...|:.|:.  ||                 |
Worm   119 KTVLVSMHKLSKFVDVNQLPEQFGGTLGYDPDSWLSKRIEIKK--WQ-----------------N 164

  Fly   191 DFAE-DVPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSG 254
            ...| |...::|::|...::.:.||||       |..|.:....|
Worm   165 YLVEVDADSSKHSLDDDQKLEEFITKL-------QSTKRIEDEYA-------------------- 202

  Fly   255 PSSAGQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFE 319
                                   |..:.|::|.::|......|..::..|.....|
Worm   203 -----------------------SNILKKSVRDVKLKEEENSKEGLIKDHTAGVSD--------- 235

  Fly   320 QDCEKMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIES 384
                 ..|||..:.:.:..|..::..|...|:||..:|::....:..:.....::..:|.||:.:
Worm   236 -----FLDWIEGSGEKWLNSLCQVADNVDEAESLVKQHEELTNKTKEIEEQSHQLAEMATRLMAA 295

  Fly   385 QHYAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPS 449
            ....|..::...:::....:.||..::.:|.....:..|..|..::
Worm   296 CPQVAIVLQKTREQIRDVAEHFAYRVEAQTQFAVSNRTFREKVAEF------------------- 341

  Fly   450 DIQSLETAIRTHQSLYEAMC-------QAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKN 507
                    |:....:.|.:|       :...|:.||.|    :||.||                |
Worm   342 --------IKKSDLMLEKVCAEDGASVKTVEELTSTKK----ELDDLV----------------N 378

  Fly   508 SNNGSF--------------NKYERQNPAADYSEGASHV---LAVIHQILSHHRTLEAKWHQERL 555
            |.|.||              .:|....||.::   .||:   |..|.|..:.|..|.:   .:||
Worm   379 SMNVSFETAMDAGEETVAKARQYSEVLPAEEF---VSHIGSSLTYISQRQNRHNELAS---VKRL 437

  Fly   556 RLHQTLALRLFQEDVKQVLDWLKNHGEVFLRKNTGIGRNFHK-----------ARVYQTSHDNFE 609
            ...|.|.|.....|..|.:.||   ||:   |.|     .||           .:..:....|.:
Worm   438 EQQQHLQLMTTYGDCDQAIKWL---GEL---KET-----LHKEYSLSDIDEDAVKNLRNDRQNLD 491

  Fly   610 NVAQNTYSNAQKLLAAADELARSG--EADPNE----IYSVARELELQVGSFAERVEQRRRRLDMA 668
            ..|.:||...::||:.|....||.  |:..:|    :.:..:||.|       .::...:||.:.
Worm   492 RTAVSTYQYGKQLLSMAKNSERSAMKESSTDERKEKLETAWKELNL-------AIQNNEQRLKVV 549

  Fly   669 VIFY-TH----------EKDVTAWIDKLRTD-------VSTDETRLSQ--ENLEGIERILQ-QYQ 712
            ..|. ||          ||.:.   ::||..       :||:..||..  |.|..|..:|. |..
Worm   550 ESFMATHRQMMERVNEIEKSLR---ERLRVSGKLNSIVLSTERKRLKNDIEELSNIGNMLSAQIN 611

  Fly   713 RDQQESSVNVCLTTISQGEALLQEMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRA 777
            .|.        .||:...:..::::     :|....:...:..:|.|   .:|.||..|:...:.
Worm   612 ADH--------ATTLQDRQTAVKQI-----SDKINEVMTAQRRMESL---IIEEEEAGSSSSGKE 660

  Fly   778 DLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEI----QNATY 835
            |     ::..|.||.||...|   ||  ..|:|..:.:|.:|:.. ||.:...    :|.:|
Worm   661 D-----KHSSRKARPLSKVPE---EE--GGDVSPVFPRAVRLLET-NEGIAPAIRLSKNESY 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	42/143 (29%)
		SPEC	314..>468	CDD:238103	20/153 (13%)
		SPEC	563..778	CDD:238103	53/252 (21%)
		SPEC	782..997	CDD:238103	16/58 (28%)
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		PH	1495..1580	CDD:278594
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2122	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
F55D12.2	NP_001250623.1	SEC14	15..145	CDD:387677	41/138 (30%)
F55D12.2	NP_001250623.1	SbcC	<183..601	CDD:223496	102/555 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910