DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and unc-73

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001021496.1 Gene:unc-73 / 171988 WormBaseID:WBGene00006805 Length:2488 Species:Caenorhabditis elegans


Alignment Length:2368 Identity:660/2368 - (27%)
Similarity:1123/2368 - (47%) Gaps:359/2368 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DGQ---RARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAA 63
            ||:   :|.|:|.:|::.:..|.|||.|.|..::..|:  |...:..::||.:..||..:.|..|
 Worm     5 DGKMTMKAEDILHVLRDGIAVLPGGRCRAGQAVIVCPS--REQPVNQDNLRNVFLYLFEVTSKMA 67

  Fly    64 KNLGFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETT 128
            :..||.|:|||||. ...|||:.|||.|....|::...|.||||:.||:||:|.:|...:.||..
 Worm    68 REKGFLVVIDMRGK-QTWTNVRHILKALSSIESSSTVQVFIIKPEKFWEKQKAQMSLGTWDFEVE 131

  Fly   129 TVSIESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFA 193
            .:|.|||.||::|..|.....|...|||.:|.:.||.:|.:.|...::.::::.::.::...:..
 Worm   132 MISFESLIKIIDSSHLPKTVGGSYPYDHDEWLELRLDLEKWIWNITEIMEKLESVRREICEGEQP 196

  Fly   194 EDVPLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSA 258
            .||..|..|:......:..|..:|:|.::.:|.|:..:|                          
 Worm   197 VDVTTANAALKKSQHAKNSIFNVPVEGIETEGNKIATRI-------------------------- 235

  Fly   259 GQQSQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCE 323
               .:||:..:    |||:.|.........:.:...:.::...|:.::::|.:.:|.:.||:|.|
 Worm   236 ---LKPSKGVK----NPDLEATTPYISNLTDSLRLLKGEVAKNWEVRQMELSKVYQQKQFERDAE 293

  Fly   324 KMFDWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVA--ARLIESQH 386
            .|.:.:...:...:.|..::|...:....|..|.::|.:|...:.|::.::....  .|.|.:::
 Worm   294 HMIETLRPYKKACERSMGDVGGCANDVVRLSAEFEQFQIAVRGMEVSVKQVFDKENHLRTIGARN 358

  Fly   387 YAAQHIKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQP--LPS 449
            ....|:   |.||...|......::.|:|||..:..|...|::|...|..|.|     ||  .|:
 Worm   359 QITDHV---AARLAEEWHLVKELMERRSAVLHNAKEFFTSAQRYFAEVPRWTA-----QPGVNPN 415

  Fly   450 DI----QSLETAIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNN 510
            |:    :|||.|||.|.:.:..:.:.|.:.:..:.|:...|                   |.:: 
 Worm   416 DVLFNQESLEEAIRKHDAFWAQVEEVYAQAYDDASKVTRAL-------------------KEAD- 460

  Fly   511 GSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLD 575
                  ...|.|.::|.          ::...|:.|..||.:.::.||..||:..|:.||:.|:|
 Worm   461 ------AEDNVAREHSS----------RLQRAHKQLMEKWKERQVLLHHMLAMIAFETDVRLVVD 509

  Fly   576 WLKNHGEVFLRKNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGE--ADPN 638
            ||:.|||.:||:|..||.|.::||.:|.:|.||:.||.|||.|.|||.....::.:||.  .|.:
 Worm   510 WLEQHGEPYLRRNIHIGENVNQARSFQRNHTNFQRVAANTYGNVQKLHQVYQDVTKSGSKICDVD 574

  Fly   639 EIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKL-------RTDVST---DE 693
            .::.:..:|..::..|.:....|...|..:|:|:||.|::|.|..|:       |.|::.   |:
 Worm   575 TMHGLMTDLSAKIEKFTKIENSRELLLRQSVLFHTHYKELTDWYGKMGEKYKDRRIDLTVPTCDK 639

  Fly   694 TRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEY---ADNTGSIAALEAT 755
            .:         ||.:.:.....|..::     ||.:|:.|::.|:....   .|.:.|:|.::..
 Worm   640 NK---------ERFVLETDETAQAYAM-----TIDEGKTLIEMMQRATRVFDVDYSASVAHIQLL 690

  Fly   756 LEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQH-ADLSRDYQKAEQL 819
            :..:..:..::...||.|:....:..:...||::...:..|::.|..:::. |:....|.||:.:
 Worm   691 ISDIEDKNTQISSEWSPRRTLLHIASKFAMFEQNQFEVLEQIKSWEVDMREMAESDSFYDKADSV 755

  Fly   820 IRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQARIEYLLDFLRE--REIDLE 882
            :..|.::..:::||..::.:..::|.|...:.....:.|      .|...:|:.:||  ||:::.
 Worm   756 LPFHKDNQQQVRNAIADIQKSAKELSQALYSQKLTDLRD------KRDRVVLEAIREHVRELEIA 814

  Fly   883 E---MSEAKRA--KLEQAVQLCQFQNDANQVISWIRNGEAMLVASFVTPN----SLQEAEQLRKG 938
            |   |:.|...  :::.|.::...:..:|.|...|.|..:.|....|.||    ::|:.|:||..
 Worm   815 ESRVMTYANETSMRMQAASEVGDLRRISNSVCKLIDNQLSALTQLGVIPNDYNDTVQKQEELRAF 879

  Fly   939 HEQFQIAIEKTHTSAVQVKYRADALIN--ANHYDPLSIDEI---SDDVTKKWQQLVTYAEERHKL 998
            .:..|..:::.:.:.| :::| :.:.|  ||.      ||:   ::.:..|:.:|:...|:|:||
 Worm   880 RDAVQHKLKEPYDAFV-IRFR-ELMENRLANR------DEVVYHNEAIQAKYCRLMNLCEDRNKL 936

  Fly   999 VTASINFYKTAE-QVCSVLDSLEREYKRE--DDWCDGGGGS---DKAQAIVQLISKHQEQKEAFL 1057
            :.::...|||.| .|..:|:.||.||...  .|||.|...|   |:|..:..|:|||.:.||.|.
 Worm   937 LKSAHGCYKTYETAVLPILNQLESEYHSPTVTDWCAGCTSSIDADRAAYVADLLSKHMDYKERFG 1001

  Fly  1058 KACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQF 1122
            |.||.|.|..:..|:|..||......:...|..:....:.:..:::.:|:.|..:|..|:.||.|
 Worm  1002 KGCTYALRNGDFLLRYIRRSTVNQSERKRHETKIADMKNNIRERQSNILELWMQKKLLLEGCQSF 1066

  Fly  1123 VLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLAD 1187
            :..|.|||:.:|::...|...|   .:.....:.|:.....|..:|:|..|:.:..::..:.|:.
 Worm  1067 IFIEASAKELLEFMKGEGNRKL---KHFEKKGRRESTDDDDEFAKFKSEVKQKKTDIQTFLMLST 1128

  Fly  1188 SLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGN--SSISSSS 1250
            :.......|..:|.:.:..|...:..||.|:.. ||           .:|.|.:|:  ||....|
 Worm  1129 NETMSRGVHGDEIDRCIEQVKDEFSRFSRRVGD-CE-----------VVLRGENGSTQSSKDEFS 1181

  Fly  1251 GDRHSDPTL--EAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEF 1313
            .|||||..:  |.|:|...:||:::.|.           |.||:|:||.|:.||..|:..:::||
 Worm  1182 LDRHSDTAIFNEKKINERREENRKMLEP-----------MRELIQSERDYIKDLERCVNIYVKEF 1235

  Fly  1314 -RAGK--SVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKF-DMYV 1374
             :|.|  ::|: |...:..|||||::|..||....|.||.|||..||.||..|:.|.... ::|.
 Worm  1236 DQAAKNGTIPT-LNPLKYEIFGNIEKIFKFHNDKLLHELIKYENQPEAVGASFIVWIDLLNELYT 1299

  Fly  1375 HYCKNKPTSNNLLVQHGG-SFFEELQRR--LEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEES 1436
            .||.||...|:::..... |||..::.|  ||:::.:.:.|||||||||:|:||::.|:..|.:.
 Worm  1300 EYCVNKEQKNHVIATPDAVSFFTGIRERHGLEINNEIASLLIKPVQRITRYRLLIEQLMRSCTDK 1364

  Fly  1437 HGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIR-KGRERRVF 1500
            ..::||..||:.:||:|.||.:|.:.|:..|..||:||..|.||....|:.:...: :|:||:||
 Worm  1365 TNDLKEAYEVVCSVPRKVNDLIHYNCLDLKDFKVDELGPFVTQDTLTFWEPRAYFKGRGKERQVF 1429

  Fly  1501 LFELYLLFAK--EVKESNVVKYQFKSK-LMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLK 1562
            ||::.::|||  ||...| :||..|.| |..:::.|.||:|||..:|.:..| :...:|.||.||
 Worm  1430 LFDISIVFAKRIEVSPKN-IKYVIKGKPLPLSEVSIVEHVEGDTCRFGLRVG-TVSSNDNRIDLK 1492

  Fly  1563 ATSLETKQIWVKKLREV----------MQETCFSGT-----SLTLPKSPAKHSGSSQRSSRDLDE 1612
            |.:..||..||:|:|::          :.|....||     |:::....:..||...|.|:|::.
 Worm  1493 ANNHHTKVKWVQKIRDLTAGMLPLGLGVSEAYSVGTLSTARSVSVRSGASTSSGGENRQSQDVES 1557

  Fly  1613 QLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVV-ADYIATSGSNE--LSVSKGQQVEIVEPP 1674
            .|    ..|.|:.|..|..:::          .|:| ||:   .|..|  |:|.||.:|||||..
 Worm  1558 LL----RHRYSVHSCDSEQSSE----------VWIVTADF---DGQVEGHLTVHKGDRVEIVEDQ 1605

  Fly  1675 TAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQ---DQ 1736
            .....::..|.|    .|...:.||||.|::.||...........:||:.|..|::..::   ..
 Worm  1606 ATDCAEYVQVVL----CDQPTKHGLVPASIIAPPESGSVPDRPDDSNASGSTVSKRKSLRRIFAN 1666

  Fly  1737 SNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQN 1801
            |::.:|.|.:||      |..|..| ..|:.|.   :|.|:          |...|..|.:.   
 Worm  1667 SSKERAAAANSS------SSNNNSP-ATRQSTS---TSSPV----------TANGHTTESST--- 1708

  Fly  1802 QQPGASPATVLPSSQFPSSTQHPGGAGAGDYEP--------------DEEVGLELPPPMKPIQEP 1852
                ::|..||.|.:..||...|..:......|              ||:....|||||:.|...
 Worm  1709 ----SAPIGVLSSGEPTSSNSIPSSSTPTHTVPSSVPATVIPIVVAEDEKAEDCLPPPMENITIN 1769

  Fly  1853 HLI----ANGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENA 1913
            :.|    .|.....|.||.|.  .:|.|.|::..|               |..:|.         
 Worm  1770 NSIDEKDMNEDSVAASDAVEP--EVALPAKVEKTP---------------EETARF--------- 1808

  Fly  1914 STNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDI 1978
                                       ||..|..||:.||:.||:||..:|.||:..:|.    :
 Worm  1809 ---------------------------KRSYVLMELVETEQDYVKDLTSVVEGYIGNLNK----M 1842

  Fly  1979 PMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLG-PLIKRSATKFALYYTYCSNK 2042
            .:|.||. ||.|::|.||.:|.|:|:..||:.:..|.::....| ..:|.......||.|||.||
 Worm  1843 DLPADLV-GKDKIIFANIVNILEFHKTNFLKEIEKCSENYEAAGAAFVKYERRLHTLYVTYCQNK 1906

  Fly  2043 PLSEYIVSA--HYQYFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPM 2105
            |.|:|:::.  ...:|...:.||||::.|.:|:|||||||.||:||:|:|:|.||.|  ..:...
 Worm  1907 PKSDYLLAQDDFEAFFADTKAKLGHKVALCDLLIKPVQRIMKYQLLLKDILKFTERA--KDKTDT 1969

  Fly  2106 LQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPM---NCVVDAAQKHRELQVFLF 2167
            |::|.|.|.||.|..:|||.|.| ||:||..::|||.|:.||.:   ..:....||.::.::|||
 Worm  1970 LKKALQVMHVVPKACDDMMQVGR-LQNFDKSLSAQGKLIHQGTLQISESIAGNVQKPKDRRIFLF 2033

  Fly  2168 QQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMK-ELGD--CRFQIRSTDPKIPEMTIICQAAS 2229
            :|..|.||....|.::.:|.:.::|...:|.|..: .:.|  .||.|:|:||..| .:.|..|.|
 Worm  2034 EQSAIIADHIPPKKEFGNPTYIFKSQFMVNKMVFEPNVPDDPLRFVIKSSDPTQP-TSFIANAQS 2097

  Fly  2230 QENYAGWRDMLNKILQQQNDLIFMLSNP 2257
            ||....|...::::|.||..|:..|.:|
 Worm  2098 QEEKDEWNRKMSELLDQQKRLLAALVDP 2125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 53/138 (38%)
SPEC 314..>468 CDD:238103 41/161 (25%)
SPEC 563..778 CDD:238103 63/229 (28%)
SPEC 782..997 CDD:238103 48/231 (21%)
SPEC 897..1119 CDD:238103 64/236 (27%)
SPEC 1125..1226 CDD:197544 21/100 (21%)
RhoGEF 1287..1456 CDD:279015 69/175 (39%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 49/135 (36%)
PH 1495..1580 CDD:278594 37/97 (38%)
SH3_Kalirin_1 1643..1707 CDD:212786 23/66 (35%)
RhoGEF 1945..2122 CDD:279015 71/179 (40%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 44/134 (33%)
unc-73NP_001021496.1 SEC14 19..156 CDD:214706 53/139 (38%)
SPEC 422..568 CDD:295325 54/181 (30%)
SPEC 849..1063 CDD:295325 62/221 (28%)
RhoGEF 1208..1383 CDD:238091 70/186 (38%)
PH-like 1391..1509 CDD:302622 48/119 (40%)
PH 1419..1511 CDD:278594 38/93 (41%)
SH3 1575..1634 CDD:302595 23/75 (31%)
RhoGEF 1813..1986 CDD:279015 71/179 (40%)
PH2_Kalirin_Trio_p63RhoGEF 1990..2128 CDD:270061 46/138 (33%)
I-set 2305..2391 CDD:254352
Ig 2335..2392 CDD:299845
FN3 2395..2473 CDD:214495
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 124 1.000 Domainoid score I3448
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20847
Inparanoid 1 1.050 812 1.000 Inparanoid score I246
Isobase 1 0.950 - 0 Normalized mean entropy S5434
OMA 1 1.010 - - QHG46230
OrthoDB 1 1.010 - - D4513at33208
OrthoFinder 1 1.000 - - FOG0002562
OrthoInspector 1 1.000 - - oto19629
orthoMCL 1 0.900 - - OOG6_103664
Panther 1 1.100 - - LDO PTHR22826
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3053
SonicParanoid 1 1.000 - - X1686
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
1413.960

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