DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and PLEKHG4B

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_443141.4 Gene:PLEKHG4B / 153478 HGNCID:29399 Length:1627 Species:Homo sapiens


Alignment Length:1269 Identity:290/1269 - (22%)
Similarity:463/1269 - (36%) Gaps:355/1269 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   673 THEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQE----------SSVNVCLTTI 727
            |.|:||.|    ....||||...|...|..|...:..:....:||          |.|...:..:
Human   489 TKEEDVLA----SSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDV 549

  Fly   728 SQ-----------------GEALLQ-EMRSLEYADNTGSIAALEATL---EKLNKQKVE---LEE 768
            ||                 |.|::| ..|||.:.....|.|.|...|   ..:.:::|.   |..
Human   550 SQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVV 614

  Fly   769 LWSARK----------------------------------FRAD--------LILRLRYFER--D 789
            |..||:                                  ||.|        ::..|:...:  |
Human   615 LVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVD 679

  Fly   790 ARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNA---------------TYEVVQ 839
            :..|:..:: .|....|.|.....|:.|.......|::..:||:               ..|::.
Human   680 SCQLTADLD-GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELID 743

  Fly   840 QGQDLLQL-FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQN 903
            |.:.:::| .|:...:|:.....|..||       ||..|:..|:    .|..||.|..|     
Human   744 QHETMMKLVLEDPLLVSLRLEGGTVLAR-------LRREELGTED----SRDTLEAATSL----- 792

  Fly   904 DANQVISWIRNGEAMLVASFVTPNSLQEAEQLR------KGHEQ------FQIAIEKTHTSAVQV 956
                   :.|..|.:......:.|.||:.|.||      :|::|      .|:|.|         
Human   793 -------YDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGLQLAKE--------- 841

  Fly   957 KYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLER 1021
                         :|...:|:..|..:....:|:.||.|...:.......:..|.|.|.:..|:.
Human   842 -------------NPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDP 893

  Fly  1022 EYKREDDWCDGGGGSDKAQAIVQLISKHQE----QKEAFLKACTLARRTAETFLKYANRSQQCYQ 1082
            |.      |.   .|..|:.   |.|.|||    ..|||..|.....:.......:|::.....|
Human   894 EA------CP---SSPVAEC---LRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQ 946

  Fly  1083 YKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSR 1147
            |.     ..:.:|::.|::        .....||....|.......|::|:. .|....::.|:.
Human   947 YP-----QTRLRLEEALSE--------AAPDPSLPPLAQSPPKHERAQEAMR-RHQKPPSFPSTD 997

  Fly  1148 SNLVGISKEETEGLL----------KEHNEFRSTAKETRERVKLLIQL-----ADSLVEKGHAHA 1197
            |.  |.:.|..:.|.          ::....|.......:.:.||..|     ..:.:|...|.:
Human   998 SG--GGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACS 1060

  Fly  1198 SDIKQWVASVDQRY--KDFSNRMDSY------------CE-----------------QLEKSLGM 1231
            |:..|.:||..:::  |....:..|:            |:                 ..||.|.:
Human  1061 SEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPL 1125

  Fly  1232 SQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTER 1296
            .|.........:.|:||.||           |:.:.::.::     :..:.|...||||::.|||
Human  1126 WQHARSPPVTQSRSLSSPSG-----------LHPAEEDGRQ-----QVGSSRLRHIMAEMIATER 1174

  Fly  1297 AYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGH 1361
            .|:..|...|..:..|... ..:|..|.|:..|||||::::|.|||:.||||||:.:..|..||.
Human  1175 EYIRCLGYVIDNYFPEMER-MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGR 1238

  Fly  1362 CFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLL 1426
            .|:....:|.|||.|.||||.|:.||..||.:||::.||.|.....|.:||::||||:.||.|||
Human  1239 SFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLL 1303

  Fly  1427 KDLL---SC---CEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW 1485
            :|||   ||   ..:..||::....|:....:..||.:.:..:..|||::.:.|::..:|.|   
Human  1304 QDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEF--- 1365

  Fly  1486 DTKQIIRKGRE---RRVFLFELYLLFAKEVK-ESNVVKYQFKSKLMTTDMGITEHIEGDETKFAV 1546
                |:..||:   |.|||||..:||:|..| |.:...|.:|....|.::|:||::.....:|.:
Human  1366 ----IVCCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEI 1426

  Fly  1547 WTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLD 1611
            |..|.....| ..:|:|:|.|.|..|...:..::.....                    .||:|.
Human  1427 WFRRRRKSQD-TYILQASSAEVKSAWTDVIGRILWRQAL--------------------KSRELR 1470

  Fly  1612 EQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTA 1676
            .|         .:||.|.||....|.|                                   |..
Human  1471 IQ---------EMASMGIGNQPFMDVK-----------------------------------PRD 1491

  Fly  1677 GEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQK------SDMQD 1735
            ..|| |.| ::.:....||....||.|::|... |...|| ||.:::..|...|      ||...
Human  1492 RTPD-CAV-ISDRAPKCAVMSDRVPDSIVKGTE-SQMRGS-TAVSSSDHAAPFKRPHSTISDSST 1552

  Fly  1736 QSNRSKADAL--------SSSTKRRGFSGRNWLP 1761
            .|:.|::.::        |||....|.    |.|
Human  1553 SSSSSQSSSILGSLGLLVSSSPAHPGL----WSP 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 35/172 (20%)
SPEC 782..997 CDD:238103 48/244 (20%)
SPEC 897..1119 CDD:238103 45/237 (19%)
SPEC 1125..1226 CDD:197544 21/146 (14%)
RhoGEF 1287..1456 CDD:279015 72/174 (41%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 36/125 (29%)
PH 1495..1580 CDD:278594 28/88 (32%)
SH3_Kalirin_1 1643..1707 CDD:212786 10/63 (16%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
PLEKHG4BNP_443141.4 Herpes_ICP4_C 186..>468 CDD:332854
RhoGEF 1165..1308 CDD:306973 66/143 (46%)
PH_puratrophin-1 1332..1467 CDD:270062 38/162 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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