DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and PLEKHG4B

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_443141.4 Gene:PLEKHG4B / 153478 HGNCID:29399 Length:1627 Species:Homo sapiens


Alignment Length:1269 Identity:290/1269 - (22%)
Similarity:463/1269 - (36%) Gaps:355/1269 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   673 THEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQE----------SSVNVCLTTI 727
            |.|:||.|    ....||||...|...|..|...:..:....:||          |.|...:..:
Human   489 TKEEDVLA----SSACVSTDGGSLHCHNPSGPSDVPARQPHPEQEGWPPGTGDFPSQVPKQVLDV 549

  Fly   728 SQ-----------------GEALLQ-EMRSLEYADNTGSIAALEATL---EKLNKQKVE---LEE 768
            ||                 |.|::| ..|||.:.....|.|.|...|   ..:.:::|.   |..
Human   550 SQELLQSGVVTLPGTRDRHGRAVVQVRTRSLLWTREHSSCAELTRLLLYFHSIPRKEVRDLGLVV 614

  Fly   769 LWSARK----------------------------------FRAD--------LILRLRYFER--D 789
            |..||:                                  ||.|        ::..|:...:  |
Human   615 LVDARRSPAAPAVSQALSGLQNNTSPIIHSILLLVDKESAFRPDKDAIIQCEVVSSLKAVHKFVD 679

  Fly   790 ARLLSVQMEMWSEELQHADLSRDYQKAEQLIRMHNESVTEIQNA---------------TYEVVQ 839
            :..|:..:: .|....|.|.....|:.|.......|::..:||:               ..|::.
Human   680 SCQLTADLD-GSFPYSHGDWICFRQRLEHFAANCEEAIIFLQNSFCSLNTHRTPRTAQEVAELID 743

  Fly   840 QGQDLLQL-FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQN 903
            |.:.:::| .|:...:|:.....|..||       ||..|:..|:    .|..||.|..|     
Human   744 QHETMMKLVLEDPLLVSLRLEGGTVLAR-------LRREELGTED----SRDTLEAATSL----- 792

  Fly   904 DANQVISWIRNGEAMLVASFVTPNSLQEAEQLR------KGHEQ------FQIAIEKTHTSAVQV 956
                   :.|..|.:......:.|.||:.|.||      :|::|      .|:|.|         
Human   793 -------YDRVDEEVHRLVLTSNNRLQQLEHLRELASLLEGNDQQSCQKGLQLAKE--------- 841

  Fly   957 KYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLER 1021
                         :|...:|:..|..:....:|:.||.|...:.......:..|.|.|.:..|:.
Human   842 -------------NPQRTEEMVQDFRRGLSAVVSQAECREGELARWTRSSELCETVSSWMGPLDP 893

  Fly  1022 EYKREDDWCDGGGGSDKAQAIVQLISKHQE----QKEAFLKACTLARRTAETFLKYANRSQQCYQ 1082
            |.      |.   .|..|:.   |.|.|||    ..|||..|.....:.......:|::.....|
Human   894 EA------CP---SSPVAEC---LRSCHQEATSVAAEAFPGAGVAVLKPHALGKPWASQQDLWLQ 946

  Fly  1083 YKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSR 1147
            |.     ..:.:|::.|::        .....||....|.......|::|:. .|....::.|:.
Human   947 YP-----QTRLRLEEALSE--------AAPDPSLPPLAQSPPKHERAQEAMR-RHQKPPSFPSTD 997

  Fly  1148 SNLVGISKEETEGLL----------KEHNEFRSTAKETRERVKLLIQL-----ADSLVEKGHAHA 1197
            |.  |.:.|..:.|.          ::....|.......:.:.||..|     ..:.:|...|.:
Human   998 SG--GGAWEPAQPLSGLPGRALLCGQDGETLRPGLCALWDPLSLLRGLPGAGATTAHLEDSSACS 1060

  Fly  1198 SDIKQWVASVDQRY--KDFSNRMDSY------------CE-----------------QLEKSLGM 1231
            |:..|.:||..:::  |....:..|:            |:                 ..||.|.:
Human  1061 SEPTQTLASRPRKHPQKKMIKKTQSFEIPQPDSGPRDSCQPDHTSVFSKGLEVTSTVATEKKLPL 1125

  Fly  1232 SQQQLLLGSDGNSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTER 1296
            .|.........:.|:||.||           |:.:.::.::     :..:.|...||||::.|||
Human  1126 WQHARSPPVTQSRSLSSPSG-----------LHPAEEDGRQ-----QVGSSRLRHIMAEMIATER 1174

  Fly  1297 AYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGH 1361
            .|:..|...|..:..|... ..:|..|.|:..|||||::::|.|||:.||||||:.:..|..||.
Human  1175 EYIRCLGYVIDNYFPEMER-MDLPQGLRGKHHVIFGNLEKLHDFHQQHFLRELERCQHCPLAVGR 1238

  Fly  1362 CFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLL 1426
            .|:....:|.|||.|.||||.|:.||..||.:||::.||.|.....|.:||::||||:.||.|||
Human  1239 SFLRHEEQFGMYVIYSKNKPQSDALLSSHGNAFFKDKQRELGDKMDLASYLLRPVQRVAKYALLL 1303

  Fly  1427 KDLL---SC---CEESHGEIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW 1485
            :|||   ||   ..:..||::....|:....:..||.:.:..:..|||::.:.|::..:|.|   
Human  1304 QDLLKEASCGLAQGQELGELRAAEVVVCFQLRHGNDLLAMDAIRGCDVNLKEQGQLRCRDEF--- 1365

  Fly  1486 DTKQIIRKGRE---RRVFLFELYLLFAKEVK-ESNVVKYQFKSKLMTTDMGITEHIEGDETKFAV 1546
                |:..||:   |.|||||..:||:|..| |.:...|.:|....|.::|:||::.....:|.:
Human  1366 ----IVCCGRKKYLRHVFLFEDLILFSKTQKVEGSHDVYLYKQSFKTAEIGMTENVGDSGLRFEI 1426

  Fly  1547 WTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLD 1611
            |..|.....| ..:|:|:|.|.|..|...:..::.....                    .||:|.
Human  1427 WFRRRRKSQD-TYILQASSAEVKSAWTDVIGRILWRQAL--------------------KSRELR 1470

  Fly  1612 EQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTA 1676
            .|         .:||.|.||....|.|                                   |..
Human  1471 IQ---------EMASMGIGNQPFMDVK-----------------------------------PRD 1491

  Fly  1677 GEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQK------SDMQD 1735
            ..|| |.| ::.:....||....||.|::|... |...|| ||.:::..|...|      ||...
Human  1492 RTPD-CAV-ISDRAPKCAVMSDRVPDSIVKGTE-SQMRGS-TAVSSSDHAAPFKRPHSTISDSST 1552

  Fly  1736 QSNRSKADAL--------SSSTKRRGFSGRNWLP 1761
            .|:.|::.::        |||....|.    |.|
Human  1553 SSSSSQSSSILGSLGLLVSSSPAHPGL----WSP 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 35/172 (20%)
SPEC 782..997 CDD:238103 48/244 (20%)
SPEC 897..1119 CDD:238103 45/237 (19%)
SPEC 1125..1226 CDD:197544 21/146 (14%)
RhoGEF 1287..1455 CDD:459876 72/173 (42%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 36/125 (29%)
SH3_Kalirin_1 1643..1707 CDD:212786 10/63 (16%)
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
PLEKHG4BNP_443141.4 PHA03307 186..>468 CDD:223039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 211..349
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 381..475
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..537 9/35 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 959..1008 10/59 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1049..1111 9/61 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1124..1159 7/50 (14%)
RhoGEF 1165..1308 CDD:459876 66/143 (46%)
PH_puratrophin-1 1332..1467 CDD:270062 38/162 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1519..1558 11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

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