Protein Alignment trio and LOC1276854

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_061499809.1
• Gene: LOC1276854 / 1276854
• VectorBaseID: AGAMI1_010503
• Length: 2083
• Species: Anopheles gambiae
• Alignment Length: 1409
• Identity: 308/1409 - (21%)
• Similarity: 519/1409 - (36%)
• Gaps: 419/1409 - (29%)

  Fly   671 FYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQ 735
            ||.|  |...|:|                    ..::|:|.|:.        |:.|..:..|:|.
Mosquito   925 FYVH--DQREWVD--------------------FFQLLEQLQQQ--------CVETGRRLVAVLG 959

  Fly   736 EMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMW 800
            ::|.:|...|           :..|:|:.:.:..............|        |.|..|....
Mosquito   960 DLRGVESQTN-----------QNQNQQQQQQQSHHHNHLQNGTATTR--------RQLHSQHRAL 1005

  Fly   801 SEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFE---------NAGFISM 856
            |..|..::|....:|....|:...:.:|.|.|.  :.::|.::|::...         |.|..:.
Mosquito  1006 SRALMDSELQSLRRKGPNTIQRLQDKLTVINNR--QTLKQTKNLVRALSVDSSARGSVNGGGTNG 1068

  Fly   857 ADATHTAQARIEYLLDFLRER---------EID-----LEEMSEAKRAKLEQAVQLCQFQNDANQ 907
            .::|......:|.  |.:..|         |:|     ||:::|.:|.:|.:..:.....::.|:
Mosquito  1069 TESTTNGVGGVEQ--DIINGRLAEVIAIYGEVDRAARKLEQLTEQRRERLREMTRQRALDDEINE 1131

  Fly   908 VISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPL 972
            ||.|:||.....:.:|..|.:|:..:..::...||:
Mosquito  1132 VICWMRNEGEQSLRTFSDPAALECPDAAKESETQFE----------------------------- 1167

  Fly   973 SIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGG-- 1035
                                           .||.||          .:...:..|.||..|.
Mosquito  1168 -------------------------------QFYYTA----------RKHVSKGRDLCDASGELE 1191

  Fly  1036 --SDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKL 1098
              .|..:.:...:.:.||:.|                           :.:...||  .::|..|
Mosquito  1192 IMRDNLKLLKDCVDEFQERLE---------------------------RVRERIEG--AARLHSL 1227

  Fly  1099 LTQENQVLDYWTLRKKSLDQCQQF----VLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETE 1159
            |..:...||. .:|.:.|...::.    .|.||..:.::.  |..|:.:.||.      .|||..
Mosquito  1228 LGMQQLKLDD-DIRTEMLKLAEKIDAPGRLIERCRRLSMP--HGGGDQHDSSS------GKEEDS 1283

  Fly  1160 GL---------------LKEHNEFRS--------------TAKETRERVKL---------LIQLA 1186
            .:               ...||...|              ||..|.|:.||         |..||
Mosquito  1284 SVSSGQHFLNHQNHPNNSSNHNNSTSDNISLDISMSDDTITATSTPEKGKLGQCLPPPPPLPALA 1348

  Fly  1187 ---DSLVEKGHAHASDIKQWVA---------------------SVDQRYKDFSNRMDS---YCEQ 1224
               .:|.|:|.....|..|.|.                     ..|:..::.|...||   .|::
Mosquito  1349 TPLPTLTEQGDDQGQDASQGVTMRHPKGHHHHHHHHHHHHHHQRHDEEDEELSKMADSGLGGCDR 1413

  Fly  1225 LEKSLGMSQQQLLLGSDGNSSISSSSGDRHSD-------PTLEAKL----------NSSN----- 1267
            .|.:..:.:.......|...::.::|.|...|       |.|:.::          ::||
Mosquito  1414 CEGNAKLERTCSCQSFDDPKNVCNNSDDLDEDCFEGISKPPLDLQIPLQANAHLYCHASNLQLDY 1478

  Fly  1268 KENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFG 1332
            :||...:::.:|:..   .||.|::.|||.||..|...|:.:.:|. ..:.:|.||.||.:||||
Mosquito  1479 EENNPFDQKTQKTLL---LIMREMIGTERDYVRSLQYVIENYTQEL-LREDIPQALRGQRNVIFG 1539

  Fly  1333 NIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEE 1397
            ||:.|..||::.||.|||..|..|..||..|:...|||.:|..|.||||.|::|:.::|..||:.
Mosquito  1540 NIERICEFHRQHFLSELESCEHHPLKVGTAFLRHESKFYLYALYNKNKPKSDSLMSENGTQFFKT 1604

  Fly  1398 LQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEE-----SHGEIKEGLEVMLNVP------ 1451
            .|..|.....|.:||:|||||:.||.|||:.|:..|.:     |:.||.|.||::....
Mosquito  1605 KQIELNDKMDLASYLLKPVQRMGKYALLLQQLMKACADLQHTNSNAEILEDLEMLQKAEEMVRFQ 1669

  Fly  1452 -KKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE--RRVFLFELYLLFAKEVK 1513
             :..||.:.:..|.:|||:|.:.|.::.|:.|..|:.|    .|::  |:|||||..:||:|..:
Mosquito  1670 LRHGNDLLAMDSLRDCDVNVKEQGRLLRQNEFLVWEGK----AGKKSLRQVFLFEELVLFSKARR 1730

  Fly  1514 ---ESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVW-TGRSPMLSDCRIVLKATSLETKQIWVK 1574
               ..|:..|.:|:.:.|:|:|:|.|:.....:|.:| ..|.|  .| ...|:..|.:.|..|.:
Mosquito  1731 FPDRKNLDIYIYKNSIKTSDIGLTAHVGDSPYRFEIWFRKRKP--GD-TWTLQTMSEDVKNAWTE 1792

  Fly  1575 KLREVMQETCFSGTSLTLPKSPAKHSGSSQ----RSSRDLDEQLTENDHDRCSLASFGS------ 1629
            ::.:::.:.......:.|.:..:...||..    |.|:|   |:  ||.. .|::..|.
Mosquito  1793 EISKLLWKQAKRNREIRLAEMSSMGIGSKPCLDIRPSQD---QI--NDRS-ISISQLGKAPKLRN 1851

  Fly  1630 ---GNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHD 1691
               |...:|.:....|.   :::  :::|.|...|||.|         |:.....|
Mosquito  1852 SFMGTLPESKSSKRPQS---IIS--VSSSSSGSSSVSTG---------TSSTTSGC--------- 1893

  Fly  1692 DAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSG 1756
                :...|.||      |:....||| ::|.|::||..|.....|:.|.:.:.:::|.......
Mosquito  1894 ----EATTVSVS------GNSNSSSGT-SSAVSNSGSSSSSSSSSSSGSSSASSTTTTSITTAGK 1947

  Fly  1757 RNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKH--AEELAEQQNQQPG------ASPATVLP 1813
            |..|.:     || |.:..||  |.|.|      ||  :..|..|.:.:.|      .||..||.
Mosquito  1948 RLTLSI-----TD-PNAPAPL--KTSYK------KHQRSTTLVSQCSMESGIIADISLSPDEVLD 1998

  Fly  1814 SSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGK 1878
            :..:|....|       .:..:......||.... :::.|.:|:        :..|||.::.|
Mosquito  1999 NPHWPHHHPH-------HHNNNNNNNHHLPKHTN-LKKTHSLAS--------STHSSGPISLP-- 2045

  Fly  1879 MDGNPLSEIEEIVKTTTEQHESNSRVDG-----GGGVENASTNG 1917
                         .|.....:....|||     ...||.|..||
Mosquito  2046 -------------ITLLPSEDGTKGVDGKPDTLSPTVEPAGDNG 2076

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103	18/106 (17%)
		SPEC	782..997	CDD:238103	38/237 (16%)
		SPEC	897..1119	CDD:238103	32/225 (14%)
		SPEC	1125..1226	CDD:197544	32/165 (19%)
		RhoGEF	1287..1455	CDD:459876	72/179 (40%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	37/127 (29%)
		SH3_Kalirin_1	1643..1707	CDD:212786	11/63 (17%)
		RhoGEF	1945..2121	CDD:459876
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
LOC1276854	XP_061499809.1	None