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Protein Alignment trio and LOC1271197

DIOPT Version :10

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_061512105.1	Gene:	LOC1271197 / 1271197	VectorBaseID:	AGAMI1_010490	Length:	1067	Species:	Anopheles gambiae

Alignment Length:	778	Identity:	161/778 - (20%)
Similarity:	277/778 - (35%)	Gaps:	225/778 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1583 TCFSGTSL----------------TLPKSPAKHSGSSQ--RSSRDLDEQLT--------ENDHDR 1621
            :|.||.||                ||.:.|..:.|::.  |....|.|.||        |....:
Mosquito    43 SCDSGISLEDPALIHTPANQPPPSTLVRRPKGNGGAASYVRRLTQLFENLTHDELRQEQERQEQQ 107

  Fly  1622 CSLASFGSGNTTDSDNKLGNQEAT-WVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVR 1685
            |::.:.......   .::..:..| .|..|........:|..:...||.||..... |.:.|...
Mosquito   108 CTMGTLAPPGVL---QQVAEESTTPEVTEDRPTAPPLLQLRAAVPCQVPIVVESVV-ESENCPAA 168

  Fly  1686 LNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTK 1750
            ....:|....|:.|.|:.    |..|.:      :|..:||..:...|..:::...|......::
Mosquito   169 SEASNDAEIAQDALAPLL----PARSRR------SNLEASAEDRVMAMSVRASGGAAVGKKRLSR 223

  Fly  1751 RR----------GFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPG 1805
            ||          |.:|...|.....:.:||....:.......:....|..:..||..||
Mosquito   224 RRQTLQGAVGGGGGAGARALGYTTPEQSDKTDGEQCYDYMYDDDEFDTSDEDEEEEREQ------ 282

  Fly  1806 ASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESS 1870
             :||...|......|   .|..|.|...|||            |.|.|
Mosquito   283 -APAVHHPDRAIAGS---EGEFGEGPTVPDE------------ISEAH----------------- 314

  Fly  1871 GNMASPGKMD-GNPLSEIEEIVKTTTEQHE--SNSRVDGGGGVENASTNGHGRSHDNNDESHTAV 1932
             ||..||.:| |.|          ..|:|:  |:|..|.                |:.|....||
Mosquito   315 -NMLVPGVVDRGTP----------HYEEHDEFSSSSFDS----------------DSEDGEPFAV 352

  Fly  1933 -SDKAAALK--KRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFN 1994
             .|..::||  :...:..||::.|..|||.|...:..|::.:...:    :|..|:|.|.. :|.
Mosquito   353 RPDSNSSLKTARVSSILQELLANEANYVQTLGRGIENYVSIMAGKH----LPPGLRGQKYH-IFG 412

  Fly  1995 NIKDIYEWHRDFFLRALRNCQKSPADLGP----LIKRSATKFALYYTYCSNKPLSEYIVSAHYQY 2055
            ||:.|:..|::.||..|.:.:.|.|.:..    .::..  ||..|..:..|:|.||.|.:.:..:
Mosquito   413 NIEKIHNLHQNQFLPMLESNRASIAGIAETFIWFLEND--KFYCYIMFALNRPKSERICNKNLDF 475

  Fly  2056 FDSIRQKLGHRLDLSNLIIKPVQRITKYELLI----KEIIKATEGA---GLYKEVPMLQEAYQQM 2113
            |...:|::..:|.|::.:::|:||:.:|:||:    |||:|..|..   .:..|:.:|.:|.:::
Mosquito   476 FQRRQQEVDDKLGLNSFLLQPIQRLPRYKLLLAEINKEILKQLEDTLLESVKDEIGILCKAEKRL 540

  Fly  2114 KVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQ-------------GPMNCVVDAAQKH----RE 2161
            :..:..||:.|.:....:.::...:.|..|:.|             .||..::...|.|    ||
Mosquito   541 ERFIDIVNEAMSINDIQECYEAPTSVQMELMNQCLAISDLFSSPLHAPMVLILRPHQDHNPSKRE 605

  Fly  2162 ----------------------------LQVFLFQQIIIFADIEKT---------------KNQY 2183
                                        .::|||::..|:|:..||               .|:.
Mosquito   606 PINLFSQGKFRKMFEVDIYDWDHRRRYPAKLFLFERSAIYAEKVKTHLEYRGRYDESEIGMHNEN 670

  Fly  2184 ASPIFKYRSHIQLNHMQMKELGD---------------CRFQIRSTD-------PKIPE-MTI 2223
            .:.::.|.....:..::: ..||               |.|.:...|       |:||. |||
Mosquito   671 RNKVYLYARKRGIQEIEV-TCGDMNEAQRLSTHVEKMMCEFAVNERDRINTMVRPRIPSVMTI 732

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.