DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and ARHGEF25

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:NP_001104740.2 Gene:ARHGEF25 / 115557 HGNCID:30275 Length:619 Species:Homo sapiens


Alignment Length:539 Identity:167/539 - (30%)
Similarity:258/539 - (47%) Gaps:87/539 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly  1767 GTDKPPSSKPL-------VKKPSEKNLRTPQKHAEELAEQQNQQP------------GASPATVL 1812
            |.:.||...||       ..:.:|.:.|..::| |.||..  .||            .||.|:.|
Human    30 GQEGPPRRSPLGLVGTEPESERTEGDHRRDREH-EVLAGA--LQPESYSIAGSEGSISASAASGL 91

  Fly  1813 PSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQ-----EPHLIANGPPAFAKDAKESSGN 1872
            .:...|||     |..:|...|..      |.|:..::     ..|.::....|.:..|......
Human    92 AAPSGPSS-----GLSSGPCSPGP------PGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENW 145

  Fly  1873 MASPGKMDGNPLSEIEEIV--------KTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESH 1929
            |..|....|..|.|:..:.        ||...:.|:.|                 ::.::.:|  
Human   146 MLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLS-----------------QAPESEEE-- 191

  Fly  1930 TAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFN 1994
                .|..||::...|.:||:.||:.||.||.:||.|||.    |.:...:||.|: |:.::||.
Human   192 ----QKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMA----TMAAQGVPESLR-GRDRIVFG 247

  Fly  1995 NIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAH-YQYFDS 2058
            ||:.|||||||:||:.|:.|.|.|..|..|..:...:..:|..||.|||.||::||.. ..||:.
Human   248 NIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEE 312

  Fly  2059 IRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDM 2123
            :||:|||||.|::|:|||||||.||:||:|:.:|....||:  :...|::|.:.|..|.|..|||
Human   313 LRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGM--DTADLEQAVEVMCFVPKRCNDM 375

  Fly  2124 MVVLRSLQDFDGEITAQGSLLMQGPMNCVVDAA-----QKHRELQVFLFQQIIIFAD-IEKTKNQ 2182
            |.:.| |:.|:|::||||.||.|.........|     .:.||.:||||:|||||:: :......
Human   376 MTLGR-LRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRG 439

  Fly  2183 YASPIFKYRSHIQLNHMQMKE--LGD-CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKIL 2244
            ...|.:.|::.|:::.:.::.  .|| |||.:.|..|:......:.|||.......|...:.:||
Human   440 GTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQIL 504

  Fly  2245 QQQNDLIFMLSNPLSTKNK 2263
            :.|.|.:..|.:|:..:.:
Human   505 ESQRDFLNALQSPIEYQRR 523

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2121 CDD:459876 79/176 (45%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 42/138 (30%)
ARHGEF25NP_001104740.2 RhoGEF 203..373 CDD:459876 79/176 (45%)
PH2_Kalirin_Trio_p63RhoGEF 378..520 CDD:270061 43/142 (30%)
Blue background indicates that the domain is not in the aligned region.

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