Protein Alignment trio and Arhgef7

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_008769602.3
• Gene: Arhgef7 / 114559
• RGDID: 620624
• Length: 901
• Species: Rattus norvegicus
• Alignment Length: 972
• Identity: 190/972 - (19%)
• Similarity: 339/972 - (34%)
• Gaps: 278/972 - (28%)

  Fly  1113 KKSLDQCQQFV------------LFERSAKQAIEWIHNTGEAYLSSR-----SNLVGISKEETE- 1159
            ||::...:.|:            |.||.....||...:..:.|....     |:||.::|...:
  Rat    89 KKTISDPEVFLQASLKDGVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLSSLVTLNKVTADI 153

  Fly  1160 GLLKEHNEFRSTAKETRERVKLLIQLADSL-VEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCE 1223
            ||..:    ...|:.:..|:|..    ||| .:..|:..|.:.|      .:|:.. :..|:...
  Rat   154 GLGSD----SVCARPSSHRIKSF----DSLGSQSSHSRTSKLLQ------SQYRSL-DMTDNANS 203

  Fly  1224 QLEKSLGMSQQQLLLGSDGNSSISSSSGD--------------------------------RHSD 1256
            ||......:.||     .....:|.|.||                                :.|:
  Rat   204 QLVVRAKFNFQQ-----TNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSE 263

  Fly  1257 PTLEAKLNSSNKENKEINEEKRKSARRKEF---IMAELMQTERAYVNDLATCIKCFLEEFRAGKS 1318
            ..:..|..:.....|..:    .:|..|.:   ::..:::||..|..:|.:.:..:|...:..:.
  Rat   264 KPVSPKSGTLKSPPKGFD----TTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLWPLQTSEK 324

  Fly  1319 VPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPE---DVGHCFVTWASKF-DMYVHYCKN 1379
            :.||   ....:.||::||..| |::.::.||:....||   .||.||::...:. .:|:.||.|
  Rat   325 LSSA---NTSYLMGNLEEISSF-QQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCAN 385

  Fly  1380 KPTSNNLLVQHG---GSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESH---G 1438
            .|::.::|.:|.   |.|.|...........|...|.||..|:.||..|||:|....|:.|   .
  Rat   386 HPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQ 450

  Fly  1439 EIKEGLEVMLNVPKKANDA-----MHLSLL-------ENCDV----SVDKLGEVVLQDAFQAWDT 1487
            :|::.:....|:..:..:.     :.|.:|       |..|:    ||..:.:|.:|.|..
  Rat   451 DIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGS---- 511

  Fly  1488 KQIIRKGRERRVFLF-ELYLLFAKEVKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRS 1551
                .:..||.:.|| .|.|:.:...:.|..:   ::.||.||.|.||: :|..|.....:....
  Rat   512 ----EEKNERYLLLFPNLLLMLSASPRMSGFI---YQGKLPTTGMTITK-LEDSENHRNAFEISG 568

  Fly  1552 PMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSL--------TLPKSP----AKHSGSSQ 1604
            .|:.  ||::...:.:....||:.|:...:.|..|..::        |||..|    :||:.|..
  Rat   569 SMIE--RILVSCNNQQDLHEWVEHLQRQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKP 631

  Fly  1605 RSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVE 1669
            .:       ||...|.....:..|:.:||                            :|.|.
  Rat   632 VA-------LTPAYHTLPHPSHHGTPHTT----------------------------ISWGP--- 658

  Fly  1670 IVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQ 1734
             :|||...:|                    ..:|.|:|.|...          .|:|...|.|
  Rat   659 -LEPPKTPKP--------------------WSLSCLRPAPPLR----------PSAALCYKED-- 690

  Fly  1735 DQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKP--PSSKPLVKKPSEKNLRTPQKHAEELA 1797
                      ||.|.|                 |.|.  |..|| .:|||::.....:..|....
  Rat   691 ----------LSRSPK-----------------TMKKLLPKRKP-ERKPSDEEFAVRKSTAALEE 727

  Fly  1798 EQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAF 1862
            :.|..:...:..|...:.|..:||..               |.:|       ...|::|:..
  Rat   728 DAQILKVIEAYCTSAKTRQTLNSTWQ---------------GTDL-------MHNHVLADDD--- 767

  Fly  1863 AKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQ-----HESNSRVDGGGG----------VEN 1912
             :.:.:|.|..:|..:::.:.|||..|.....|..     ..|.||.:....          ||.
  Rat   768 -QSSLDSLGRRSSLSRLEPSDLSEDSEYDSLWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEE 831

  Fly  1913 ASTNGHGRSHDNN-DESHTAVSDKAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINN 1973
            ..:||.....:.: .::..|:.|:...|::......:.:..|:...:||.::|...:..:|:
  Rat   832 TKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMND 893

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103	2/5 (40%)
		SPEC	1125..1226	CDD:197544	23/107 (21%)
		RhoGEF	1287..1455	CDD:459876	46/177 (26%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	30/133 (23%)
		SH3_Kalirin_1	1643..1707	CDD:212786	8/63 (13%)
		RhoGEF	1945..2121	CDD:459876	5/29 (17%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Arhgef7	XP_008769602.3	None