DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Mcf2

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_006527813.1 Gene:Mcf2 / 109904 MGIID:96932 Length:1127 Species:Mus musculus


Alignment Length:955 Identity:232/955 - (24%)
Similarity:398/955 - (41%) Gaps:217/955 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   679 TAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEYA 743
            |:::.:..||:.   .|.|||              |.......|.|:::|.         .|.|.
Mouse   216 TSFLQRTFTDIG---FRFSQE--------------DFMLKLPVVMLSSVSD---------LLTYI 254

  Fly   744 DNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILR--LRYFERDARLLSVQMEMWSEELQH 806
            |:......|..||:..:.:       |        :|.|  :..|....:.::..::.:..||..
Mouse   255 DDKQLTPELGGTLQ
YCHSE-------W--------IIFRNAIEKFAVTVKEMAQMLQSFGTELAE 304

  Fly   807 ADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLFENAGFISMADATHTAQAR----- 866
            .:|.:|....|:::....|....::|....|.::|:.||...:    :...:.|.::...     
Mouse   305 TELPQDILSIEEILAGRAERYHLLKNDLTAVTKEGKVLLMNLQ----VPATEETVSSSLECTQHI 365

  Fly   867 ------IEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVISWIRNGEAML----VA 921
                  |:.||..:.:.|...:...|..:.|:||.:||.:|:.|..:.::.:   |.:|    ..
Mouse   366 NGDWQTIKKLLAQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQEAVTQV---EFLLSQQREL 427

  Fly   922 SFVTPNSLQEAEQLRKGHEQFQIAIEKTH---TSAVQVKYRADALINANHYDPLSIDEISDDVTK 983
            ..:|.|..|..::|:|    .:|..:|:.   |.|..|..|...|.:.:||   ::|.|.....:
Mouse   428 GDITGNLAQVKQRLKK----LEILDDKSQELLTKARIVILRGHKLASNHHY---ALDLICQRCNE 485

  Fly   984 -KWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGG------GGSDKAQA 1041
             ::...:...|.|.|.|..|..|            .:.|..::....||.|      .|.||.| 
Mouse   486 LRYLSDILVNEIRTKRVQLSRTF------------KVHRLLQQARQCCDQGECLLASQGMDKFQ- 537

  Fly  1042 IVQLISKHQEQKEAFLKACTLARRTAETFLKYA----NRSQQCYQYKGNCEGHVKSKLDKLLTQE 1102
                 :|...||         |.:..:.||:.|    |...:..||          :.|.||:.|
Mouse   538 -----TKEDAQK---------ALQDVDNFLQMAMPFINYDIESLQY----------EFDVLLSPE 578

  Fly  1103 NQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNE 1167
            .:.            |.|...|          .:.|...|:.:.::....: ||..||..:  |.
Mouse   579 LKA------------QMQNIQL----------KLENIRSAFQNQQAGCKSL-KEVPEGAFQ--NL 618

  Fly  1168 FRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMS 1232
            ..::....|.|   :|..:...|..|::.....:.:: .|.:.::....:.:...|.:|      
Mouse   619 VPASENVMRSR---MIFFSPKHVGIGYSFFQACRIFL-KVKKSWRQIHAQSNVKVEAVE------ 673

  Fly  1233 QQQLLLGSDGNSSISSSSGDRHSD--PTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTE 1295
                            .|.:::||  |.|:..|:.                 .|..::.||:|||
Mouse   674 ----------------DSQEKNSDQSPKLDNSLDI-----------------LKNHVLNELIQTE 705

  Fly  1296 RAYVNDLATCIKCFLEEF---RAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPE 1357
            ||||.:|.|.:..:..|.   :....:|..|..::||:|||:.||:.||..||:..||.....||
Mouse   706 RAYVRELFTVLLGYRSEMDNPQMFDLMPPLLRNKKDVLFGNMAEIYEFHNNIFMSRLEDCSDAPE 770

  Fly  1358 DVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGG-SFFEELQRRLEVDHPLPAYLIKPVQRITK 1421
            .||.||:.....|.||..||:|||.|..:..::.. :||:|.||:|:....|.:||:||||||||
Mouse   771 RVGPCFLERKDDFQMYAKYCQNKPRSELIWRKYSECAFFQECQRKLKHRLGLDSYLLKPVQRITK 835

  Fly  1422 YQLLLKDLLSCCEESHG--EIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQA 1484
            ||||||:||...:|..|  ::||.|:.||.:.|..||:||.:.:.....::::||::|||.:|..
Mouse   836 YQLLLKELLKYSKEGEGTTKLKEALDSMLELLKSVNDSMHQTAINGYVGNINELGKMVLQGSFNV 900

  Fly  1485 W--------DTKQIIR-KGRERRVFLFELYLLFAKEVKES-----NVVKYQFKSKLMTTDMGITE 1535
            |        ..|...| |..:|.:||:|..::|.|...||     ....|.||..|...|:||||
Mouse   901 WLGHRKGATKMKDFARFKPMQRHLFLYEKAVMFCKRRFESGEGADRYPSYSFKHCLKMEDVGITE 965

  Fly  1536 HIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVM 1580
            |::||..||.:.......:    .:::|.:::.|.:|:|::|:::
Mouse   966 HVKGDNRKFEIRYSEKEEI----YIVQAPNVDVKMLWLKEIRKIL 1006

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 18/98 (18%)
SPEC 782..997 CDD:238103 46/235 (20%)
SPEC 897..1119 CDD:238103 50/239 (21%)
SPEC 1125..1226 CDD:197544 14/100 (14%)
RhoGEF 1287..1456 CDD:279015 75/174 (43%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 37/133 (28%)
PH 1495..1580 CDD:278594 27/89 (30%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Mcf2XP_006527813.1 SEC14 128..268 CDD:214706 16/77 (21%)
SPEC 408..599 CDD:351773 52/259 (20%)
RhoGEF 694..871 CDD:238091 76/176 (43%)
PH-like 878..1009 CDD:388408 37/133 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4240
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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