Protein Alignment trio and VAV3

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: NP_006104.4
• Gene: VAV3 / 10451
• HGNCID: 12659
• Length: 847
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 89/391 - (22%)
• Similarity: 159/391 - (40%)
• Gaps: 76/391 - (19%)

  Fly  1888 EEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAVSDKAAALKKRQCVFAELMST 1952
            |.:|:...:.::.....|.||.|           :::..::..|...|......|.|..||:..|
Human   150 ETLVEDEEDLYDCVYGEDEGGEV-----------YEDLMKAEEAHQPKCPENDIRSCCLAEIKQT 203

  Fly  1953 EEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRN--CQ 2015
            ||.|.:.|..|...:|.         |:...|...:...||.||.::.:.||: .::.:.:  ..
Human   204 EEKYTETLESIEKYFMA---------PLKRFLTAAEFDSVFINIPELVKLHRN-LMQEIHDSIVN 258

  Fly  2016 KSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHY--QYFDSIRQKL--------GHRLDLS 2070
            |:..:|..:......:..:|..|||.  :...|.|..|  :..:.::.||        ..:..|.
Human   259 KNDQNLYQVFINYKERLVIYGQYCSG--VESAISSLDYISKTKEDVKLKLEECSKRANNGKFTLR 321

  Fly  2071 NLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMM---VVLRSLQD 2132
            :|::.|:||:.||.||::|::|.|...   .|...|:.|...||.:.:.||::.   ..||.::.
Human   322 DLLVVPMQRVLKYHLLLQELVKHTTDP---TEKANLKLALDAMKDLAQYVNEVKRDNETLREIKQ 383

  Fly  2133 FDGEI--TAQGSLLM---QGPMNCVVDAAQKH--RELQVFLFQQIIIFADIEKTKNQYASPIFKY 2190
            |...|  ..|..||.   ||.....:....||  :|..:|||...:|   :.|.|.
Human   384 FQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTKQERHIFLFDLAVI---VCKRKG--------- 436

  Fly  2191 RSHIQLNHMQMKELGDC-RFQIR---STDPKIPEMT---IICQAASQ---ENYAGWRDMLNKILQ 2245
                  ::.:|||:.|. :::|.   :||.:..:.:   .:.....|   |.|...:|:..|.|:
Human   437 ------DNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQNGLEFYCKTKDLKKKWLE 495

  Fly  2246 Q 2246
            |
Human   496 Q 496

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1455	CDD:459876
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060
		SH3_Kalirin_1	1643..1707	CDD:212786
		RhoGEF	1945..2121	CDD:459876	45/187 (24%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	30/134 (22%)
VAV3	NP_006104.4	CH_VAV3	2..118	CDD:409113
		RhoGEF	193..369	CDD:238091	47/190 (25%)
		PH_Vav	383..506	CDD:269930	30/132 (23%)
		C1_VAV3	506..564	CDD:410419
		Sufficient for interaction with ROS1. /evidence=ECO:0000269|PubMed:11094073	560..847
		SH3_VAV3_1	596..657	CDD:212914
		SH2_Vav3	666..768	CDD:198270
		SH3_VAV3_2	791..846	CDD:212911