DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and Plekhg4

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_006530585.2 Gene:Plekhg4 / 102075 MGIID:2142544 Length:1235 Species:Mus musculus


Alignment Length:1170 Identity:254/1170 - (21%)
Similarity:427/1170 - (36%) Gaps:324/1170 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   738 RSLEYADNTGSIAALEATLEKLNKQKVEL---EELWSARKFRADLILRLRYFER----------- 788
            |.|.:......:|||..|.:...:..:.|   ...|...|..:..:|.|.::.|           
Mouse   211 RDLAWELLASGMAALPGTRDVEGRAVLLLCAHSPAWLHPKSNSHELLSLLFYLRGIPRPEVQALG 275

  Fly   789 -----DARLLSVQMEM-WS-EELQHAD------------LSRDYQKAEQ--LIRMHNESVTEIQN 832
                 |||:.|....: |. ..||.|.            :..|.....|  .:|.|...:|.|.|
Mouse   276 LTVLVDARVCSPSSSLTWGLSRLQEASPGSVQQVLLIGKMPEDVPVGLQWKQLRSHQSLLTHIPN 340

  Fly   833 --------ATYEVVQQG-QDLLQLFENAGFISMADATHTAQARIEYLLDFLREREIDLE-----E 883
                    .:.....|| .|.....|     ::..:...|.|.::.::|.::.....:|     :
Mouse   341 VELPTSLGGSLSYCHQGWLDFRMRLE-----ALQQSCQVACALLQGVIDSMKALRPPMESGEVAQ 400

  Fly   884 MSEAKRAKLEQAV---QLCQFQNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIA 945
            :.:..::.::|.:   ||...|:..:|.::|::.|         ||                ::.
Mouse   401 LLQQTQSLMQQVLDSPQLSWLQSQGSQELAWLKQG---------TP----------------RVT 440

  Fly   946 IEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAE 1010
            :...:.|||.   :||||..       .:||:...:..|..|.:                  .|.
Mouse   441 LSPDYRSAVD---KADALYG-------QVDELLHQLALKSNQRI------------------RAL 477

  Fly  1011 QVCSVLDSLEREYKREDDWCDGGG-------GSDKAQAIVQLISKHQE----------------Q 1052
            ::...|::.|...::.:.|....|       |......::|.....||                |
Mouse   478 ELLQALEAQEGVLRQIEVWLQEVGWPGVEEPGEPSLDTLLQAQGPFQELDLVAQEQVTQGEKLLQ 542

  Fly  1053 KEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLD 1117
            ....|:|..|. ...:.||  |.|||                    ||:.::.|   ..|::.|.
Mouse   543 PLVGLEAAELG-SPGKRFL--ALRSQ--------------------LTEFSRAL---AQRRQRLA 581

  Fly  1118 QCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRE----- 1177
            ..::...|   .|||..|..       ..|..|..:.:|..|.:|:     |.....||.     
Mouse   582 DAEKLFQF---FKQASTWTE-------EGRRLLTELEQERPEVVLQ-----RLQLHWTRHPDLPP 631

  Fly  1178 -RVKLLIQLADSLVEKG--------HAHASDIKQWVASVDQRYK-------DFSNRMDSYCEQ-- 1224
             ..:.:..||..|..:|        .|...|  .|:| :||:.:       ..:|....|..:  
Mouse   632 AHFRKMWALATGLGSEGIRQECRCAWAQCQD--TWLA-LDQKREAALKPMPATNNTATLYVRRAP 693

  Fly  1225 -------------LEKSLGMSQQQLLLGSDGNSSISSSSG-------DRHSDPTLEAKLNSSNKE 1269
                         .:::||...|.:           ||.|       |.|..   ||:.....:.
Mouse   694 AVPTVPPLRKAYSFDRNLGRHLQDV-----------SSRGHCAAIVTDCHRP---EARGGVRPRS 744

  Fly  1270 NKEI---NEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIF 1331
            :..:   .....:|..|.:.::||::.|||.||..|...|:.:..|... ..||..|.||...:|
Mouse   745 SPPVPLSGSSDFRSPNRLQLVLAEMVATEREYVRALDYTIQNYFPELDR-PDVPQGLRGQRAHLF 808

  Fly  1332 GNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFE 1396
            ||::::..||...||||||.....|..|.|.|:....:|.||..|.||||.|:.|:..:|.:||:
Mouse   809 GNLEKLRDFHYNFFLRELEACTRHPPRVAHAFLRHRVQFGMYALYSKNKPRSDALMTNYGHTFFK 873

  Fly  1397 ELQRRLEVDH-PLPAYLIKPVQRITKYQLLLKDLLSCC---EESHGEIKEGLEVMLNVPKKANDA 1457
            |.|:.|. || .|.:||:||:|.::||.|||::|...|   .:..|.::....::....:..||.
Mouse   874 EKQQALG-DHLDLASYLLKPIQHMSKYALLLQELARACGGPAQELGALQAAQSLVHFQLRHGNDL 937

  Fly  1458 MHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE---RRVFLFELYLLFAKEVK-ESNVV 1518
            :.:..::.|||::.:.|::|.||.|       .:|.||.   |||||||..|||:|..: .:.|.
Mouse   938 LAMDAIQGCDVNLKEQGQLVRQDEF-------TVRAGRHKACRRVFLFEELLLFSKPRRGPAGVD 995

  Fly  1519 KYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQET 1583
            .:.:|......|:|:||.....:.:|.:|..|.....  ..||:|:.:.|||.|...:..::...
Mouse   996 IFTYKRSFKMADLGLTECCGESQLRFEIWFRRRKARD--LFVLQASDVATKQAWTADISRLLWRQ 1058

  Fly  1584 CFSGTSLTLPKSPAKHSGS--------SQR--SSRDLDEQLTEND-HDRCSL--ASFGSGNTTDS 1635
            ......:.:.:..:...||        |:.  :.|:::..|...| ..|.|:  |.|      |.
Mouse  1059 AVHNKEVRMAEMASMGVGSKAFWDIAPSEEAINDRNINYVLKRRDVRSRASIAVAPF------DC 1117

  Fly  1636 DNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIV------EPPTAG------EPDFCLVRLNP 1688
            ||            .|:...||.....:.|..:..:      :|...|      .|:|       
Mouse  1118 DN------------PYLGALGSLPGDRASGSVLGSLNLHLYRDPALMGGHWSLYPPNF------- 1163

  Fly  1689 QHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRG 1753
             .::|::..|..|  .|.|      ..|..::...|::||..||         :..:|..|..||
Mouse  1164 -SEEASLDLGSQP--SLTP------EDSEVSSQCPSASGSSDSD---------SSCVSGQTMGRG 1210

  Fly  1754  1753
            Mouse  1211  1210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 9/42 (21%)
SPEC 782..997 CDD:238103 45/263 (17%)
SPEC 897..1119 CDD:238103 43/244 (18%)
SPEC 1125..1226 CDD:197544 25/136 (18%)
RhoGEF 1287..1456 CDD:279015 62/172 (36%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 38/125 (30%)
PH 1495..1580 CDD:278594 28/88 (32%)
SH3_Kalirin_1 1643..1707 CDD:212786 12/75 (16%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
Plekhg4XP_006530585.2 SEC14 230..351 CDD:417771 21/120 (18%)
SPEC 475..>626 CDD:413338 36/191 (19%)
RhoGEF 762..928 CDD:238091 62/167 (37%)
PH_puratrophin-1 928..1063 CDD:270062 40/143 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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