Protein Alignment trio and LOC101886810

DIOPT Version :10

• Sequence 1: NP_651960.2
• Gene: trio / 43974
• FlyBaseID: FBgn0024277
• Length: 2263
• Species: Drosophila melanogaster
• Sequence 2: XP_021325545.2
• Gene: LOC101886810 / 101886810
• -ID: -
• Length: 1516
• Species: Danio rerio
• Alignment Length: 1066
• Identity: 240/1066 - (22%)
• Similarity: 395/1066 - (37%)
• Gaps: 349/1066 - (32%)

  Fly  1190 VEKGHAHASDIKQWVASVDQRYKDFSNRMDS-YCEQLEKSLGMSQQQLLLGSDGNSSISSSSGDR 1253
            |..|.|..:.:...:.|...||.. |..||| :|.....|.            |::|.|:||.|.
Zfish    19 VPVGGAVLNQVSGPIRSSALRYCS-SRSMDSTHCSDRPVSY------------GSTSSSASSRDS 70

  Fly  1254 H----------SDP-----------------TLEAKLNSSNKENKEINEE---KRKSARRKEF-- 1286
            |          |.|                 .||.:..|..|..|..|::   :....|:.::
Zfish    71 HCSLGGRPVLGSTPERDRDSGAIRLELVPARQLEEEEESGRKTRKLTNQDAEIQSPEGRKVQYVD 135

  Fly  1287 -IMAELMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQED--VIFGNIKEIHHFHQKIFLRE 1348
             ::.|:::||:.||.||.:.::.:|:.. :.:|:  .|:|.|:  .:||||::|:.|:.:: ||:
Zfish   136 RVVEEILETEKTYVQDLRSIVQDYLDCI-SNQSL--LLLGDEERNSLFGNIRDIYRFNSEL-LRD 196

  Fly  1349 LEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTS--------NNLLVQHGGSFFEELQRRLEVD 1405
            |||....|..:..|||..:..|.:|..||.|.|.|        .|.:|   ..|..|.|..|:..
Zfish   197 LEKCNANPVAIAKCFVAKSEDFHIYTQYCTNYPRSVAVLTECMRNKMV---AKFLRERQESLKHS 258

  Fly  1406 HPLPAYLIKPVQRITKYQLLLKDLLSCCE---ESHGEIKEGLEVMLNVPKKAND-------AMHL 1460
            .||.:||:||||||.||.|||.::.:..|   |.:..|:|.::.|..|....||       |:.|
Zfish   259 LPLGSYLLKPVQRILKYHLLLHEIATHLEKDSEMYDVIQEAIDTMQRVAWHINDMKRKHEHAVRL 323

  Fly  1461 ----SLLENCDVSVDKL--GEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVK 1519
                |||.|.. ..|.:  ||:||:..|      :|.|...||.:|||:..||..|:.:|:
Zfish   324 QEIQSLLTNWK-GPDLIGYGELVLEGTF------RIQRAKNERTLFLFDKLLLITKKREET---- 377

  Fly  1520 YQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC 1584
            |.:|:.::..::.:.|.|..:...|:|:..::|.|..   .::|.|.:.|::||..|:.::.|.
Zfish   378 YTYKAHILCCNLMLVEVIPKEPLSFSVFHYKNPKLQH---TVQAKSQQDKKMWVLHLKRLILEN- 438

  Fly  1585 FSGTSLTLPKSPAK-----------------HSGSS--------------QRSSRDLDEQLTEND 1618
                  ...|.|||                 |:...              :|.:..|.:.|..:.
Zfish   439 ------HPAKIPAKAKQAILEMDTANHPSFNHNSDDKRVNTKEGPSPRRVRRKTEPLSKLLKNSK 497

  Fly  1619 H--------DRCS--------LASFGS-----------------GNTTDSDNKLGNQEATWVVAD 1650
            |        .|.|        :||.||                 |:.:|.|::...|:|
Zfish   498 HIISSPDIQKRSSFGVTLLSPVASLGSIGRSRSLVSESQESLDPGDHSDVDDEPNTQDA------ 556

  Fly  1651 YIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQ---------------HDDAAVQEGLV 1700
                ...::..:|.|.::.:   |..|...    |||.|               |.|....:..:
Zfish   557 ----DDEDDTGLSSGGKLRV---PGKGSRK----RLNQQVSVDSIEQWRNNDLTHADLQTAKQSL 610

  Fly  1701 PVSVLKP-------PPGS--HKH-----GSGTA-----------ANAASSAGSQKS----DMQD- 1735
            ...|:.|       ||.|  .:|     |:|.|           ...|.....|||    |.:|
Zfish   611 QNKVITPPILRVTAPPESDGDEHLRAMLGTGQAPAFCNIWTDHRVRRAMFPTRQKSFQIDDDEDI 675

  Fly  1736 -------QSNRSKADALS------------------SSTKRRGFSGRNWLPLMNRKGTDKPPSSK 1775
                   ::..|..||.|                  :.|.|.|..||..|...|..|
Zfish   676 YQMFLPTENEVSSHDAESDHETADHPERPCSWHVEPTKTSRLGLPGRGVLRRANSFG-------- 732

  Fly  1776 PLVKKPSEKNLRTPQKHAEELAEQQ-----NQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPD 1835
               ::||.:.:.|.|...||....|     |:..|:|.|..|.:....:...:.      .:|..
Zfish   733 ---EEPSGQEIPTKQSLEEEEINNQTESSSNEISGSSSAEQLTADDIENVYDNI------SFEEL 788

  Fly  1836 EEVGL-------ELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDGNPLSEIE-EIVK 1892
            :.:||       ...|.:||:..|.:|..     ..:.:.|.|:..|.|: :|.|....| :||
Zfish   789 QAMGLIRKDQVNHAVPEVKPMIAPQVIIT-----PTETESSCGSNRSSGQ-EGEPFETCELQIV- 846

  Fly  1893 TTTEQHESNSRVDGGGGVENASTNGHGRSHDN------------NDESHTAVSDKAAALKKRQCV 1945
                ::|.|                   .:|.            :||...|:     .|:..
Zfish   847 ----ENEEN-------------------VYDTIVFQECPVIAAPSDEGKPAI-----VLRSE--- 880

  Fly  1946 FAELMSTEEAYVQDLHEIVNGYMTEIN---NTNSDIP---MPEDLKGGKMKLVFNNIKDIYEWHR 2004
             |::::|:.:         .|:::|.|   .|.:|..   :|.|::..::....|.::.:.|...
Zfish   881 -ADIIATQNS---------GGFVSEENLCTKTKTDFEHPHVPSDIETSQLSSADNTLEQVDEIWT 935

  Fly  2005 DFFLRALRNCQKSPADLGPLIKRSAT 2030
            | ....:|..:|.|..|......|.|
Zfish   936 D-LENYIRKNEKKPDKLPAAFPVSGT 960

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544	11/36 (31%)
		RhoGEF	1287..1455	CDD:459876	61/180 (34%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	35/123 (28%)
		SH3_Kalirin_1	1643..1707	CDD:212786	12/78 (15%)
		RhoGEF	1945..2121	CDD:459876	18/92 (20%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
LOC101886810	XP_021325545.2	None