DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment trio and Plekhg2

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_006539499.1	Gene:	Plekhg2 / 101497	MGIID:	2141874	Length:	1366	Species:	Mus musculus

Alignment Length:	854	Identity:	201/854 - (23%)
Similarity:	325/854 - (38%)	Gaps:	186/854 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1230 GMSQQQLLLGSDGNSS--ISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELM 1292
            |.|.....:||:|:.|  .|:|..:...:|.:...|       ..:..:......|.|.:..|::
Mouse    51 GSSTSLSTVGSEGDPSPACSASRPEPLPEPPIRLHL-------LPVGIQGSVKPSRLERVAREIV 108

  Fly  1293 QTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDV--IFGNIKEIHHFHQKIFLRELEKYETM 1355
            :||||||.||.:.::.:|.....|:::.   :..|.|  :|.||::|:.|..:: |.:||...:
Mouse   109 ETERAYVRDLRSIVEDYLGPLMDGRALG---LNMEQVGTLFANIEDIYEFSSEL-LEDLEGCSS- 168

  Fly  1356 PEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGS-----FFEELQRRLEVDHPLPAYLIKP 1415
            ...:..|||..:..||:|..||.|.|:|..||.:...|     :.:|.|.:|....||.::|:||
Mouse   169 AGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSVSPPATLWLQERQAQLRHSLPLQSFLLKP 233

  Fly  1416 VQRITKYQLLLKDLLSCCEE---SHGE--IKEGLEVMLNVPKKANDAM----HLSLLENCD---- 1467
            ||||.||.|||::|.....|   |.|.  ::|.:..|..|....||..    |.:.|:...
Mouse   234 VQRILKYHLLLQELGKHWAEGPDSGGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLG 298

  Fly  1468 ----VSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESNVVKYQFKSKLMT 1528
                ..:...||:||:..|:.........:|.||.:|||...||.||.    ...:|.:|..:..
Mouse   299 GWTGPELSAFGELVLEGTFRGGGGGGPRLRGGERLLFLFSRMLLVAKR----RGPEYTYKGHIFC 359

  Fly  1529 TDMGITEHIEGDETKFAVWTGRSPM---LSDCRI-----VLKATSLETKQIWV------------ 1573
            .::.::|            |.|.|:   :||..|     :.:|.:.|.|::|:
Mouse   360 CNLSVSE------------TPRDPLGFKVSDLTIPKHRHLFQAKNQEEKRLWIHCLQRLFFENHP 412

  Fly  1574 ----KKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDLDEQLTENDHDRCSLASFGSGNTTD 1634
                .|.::|:.|....    ..|||  ||......|..|     :....|...... |..|...
Mouse   413 ASIPAKAKQVLLENSLH----CAPKS--KHIPEPPTSPLD-----SPRPRDAPGFTP-GRRNPAP 465

  Fly  1635 SDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQ--- 1696
            |....|::.......:|....| :..|...|.......||...:..:.:.   ||:|...|:
Mouse   466 SPRLSGSRRGRRQSGEYPPLEG-DPGSQWPGLLTSFFLPPEPAKEAYVIF---PQNDKPQVKHAG 526

  Fly  1697 -EG-LVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNW 1759
             || |.|.|.|:|                .||.....|::|....:...:.:|.|:       ..
Mouse   527 SEGELHPSSELQP----------------VSASGPPEDLEDAGPPTLDPSGTSITE-------EI 568

  Fly  1760 LPLMNRKG-TDKPPSSKPLVKKPSEKNL---------------RTPQKHAEELAEQQNQQPGASP 1808
            |.|:|::| .|..|::..:.|.|.:..:               .:.::..||..|...::|  ||
Mouse   569 LELLNQRGLRDSGPATHDIPKFPRDSRVPVESEPLPFQSLPSRESSEEEEEEDLETDEREP--SP 631

  Fly  1809 ATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGL-ELP-PPMKP--------IQEPHLIANGPPAFA 1863
            ..||...:..|:.:.|......|. |.|...| |:| .|..|        .:.|.|   .|.:..
Mouse   632 LHVLEGLEGSSAAEIPCIPSLTDI-PSEVPSLPEIPEAPCLPCLSDISGVFEVPCL---SPTSTV 692

  Fly  1864 KDAKESSGNMASP-GKMDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDE 1927
            .|....:...:.| |.....||   :|..:....:.|..|..:.|...|:.|.:..|:..|....
Mouse   693 PDIPSLATTPSFPCGSWLPGPL---QEAAQPQATRRELLSGSNPGRLSESPSESREGQEDDTEGV 754

  Fly  1928 SHTAVSDKAAA--------LKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMP--- 1981
            |.:||..:|..        |:.|.|  :|:.|..:|..|       |.:     .....|.|
Mouse   755 SFSAVQREAGTSVQGFPEELEYRSC--SEIRSAWQALEQ-------GQL-----ARPGFPEPLLI 805

  Fly  1982 ---EDLKGG 1987
               .||:||
Mouse   806 LEDSDLRGG 814

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706
		SPEC	314..>468	CDD:238103
		SPEC	563..778	CDD:238103
		SPEC	782..997	CDD:238103
		SPEC	897..1119	CDD:238103
		SPEC	1125..1226	CDD:197544
		RhoGEF	1287..1456	CDD:279015	59/180 (33%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	32/153 (21%)
		PH	1495..1580	CDD:278594	23/108 (21%)
		SH3_Kalirin_1	1643..1707	CDD:212786	16/68 (24%)
		RhoGEF	1945..2122	CDD:279015	11/49 (22%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061
Plekhg2	XP_006539499.1	RhoGEF	103..278	CDD:366202	59/179 (33%)
		PH_PLEKHG1_G2_G3	260..410	CDD:270063	35/165 (21%)
		PTZ00449	<351..742	CDD:185628	90/450 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910