DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and mcf2l

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_012813354.1 Gene:mcf2l / 100497730 XenbaseID:XB-GENE-6042031 Length:1216 Species:Xenopus tropicalis


Alignment Length:1263 Identity:288/1263 - (22%)
Similarity:476/1263 - (37%) Gaps:334/1263 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   736 EMRSLEYADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMW 800
            |:.|  |.|.|.....|..||:..:..       |.:.:      ..:..|....:..:..::.:
 Frog   203 ELHS--YIDKTQLTRDLGGTLDYCHTN-------WLSHR------TAIENFAVMVKQTAQMLQSF 252

  Fly   801 SEELQHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQQGQDLLQLF-----ENAGFISMADAT 860
            ..||...:|..|......|:..|.|...::::.....:.||.|:|...     ||..:....|..
 Frog   253 GTELAETELPNDVPSTSLLLHAHTEKKEKMKDHLKIALTQGCDILNKIMEPRKENPEYRMNQDQL 317

  Fly   861 HTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQFQNDANQVISWIRNGEAMLVASFVT 925
            .. |..:|.||..|.|.|...:|.......||||.:||..|:.:..::.:.:......|.|....
 Frog   318 DN-QTTVERLLLQLNETEAAFDEFWSKHEQKLEQCLQLRHFELNFREISTSLDGISERLEAFTDV 381

  Fly   926 PNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSIDEISDDVTKKWQQLVT 990
            .||...||.:.|....|::...:...:|..:....|.||.:|||...||....|::......:..
 Frog   382 GNSCSHAEHILKDFCNFEVKSREVLQTAQNLVREGDQLIKSNHYAVDSILPKCDEIGHLCDSISN 446

  Fly   991 YAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKEA 1055
            ..::|.:      |.:|:.|        |.|..::...|||.|                     .
 Frog   447 TIQQRRQ------NLHKSLE--------LHRHLEKTMKWCDEG---------------------I 476

  Fly  1056 FLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQCQ 1120
            ||.|                                ...:||..:|:.                 
 Frog   477 FLLA--------------------------------SQPVDKFQSQDG----------------- 492

  Fly  1121 QFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQL 1185
                 ..:|.|.|.....||          ..|:.::...:||.:|..  ...|.:|.|..:.|.
 Frog   493 -----AEAALQEITRFLETG----------TDITMKDLAFILKMYNSI--LTPELQEHVNKVYQK 540

  Fly  1186 ADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSS 1250
            .:|:.|........:::..|...:..:..:.|.::..:....|.|:.:               ||
 Frog   541 QESMQEMFEKRKGSLRKLAAKQTRPVQPVAPRPEAISKSPTSSPGLHR---------------SS 590

  Fly  1251 GDRHSDPTLEAKLN---------SSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCI 1306
            ..|:|..:::.::|         .|...:..:.|::...|..:..:|.||::||||||.:|.:.|
 Frog   591 ESRYSSGSIQRRINYRRAKSEVDGSQMRSTSVMEDEENLAVLRRHVMNELIETERAYVEELLSVI 655

  Fly  1307 KCFLEEFR---AGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWAS 1368
            :.:..|..   ....:||.|..::||:|||::||:.||.:|||||||.|...||.||.||:....
 Frog   656 EGYAAEMNNPLVMDLIPSVLQNKKDVLFGNMEEIYQFHNRIFLRELEHYRDYPELVGRCFLERME 720

  Fly  1369 KFDMYVHYCKNKPTSNNLLVQ-HGGSFFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSC 1432
            .|.:|..||:|||.|.:|..| ...:||::.|::|:....|.:||:||||||||||||||::|..
 Frog   721 DFQIYEKYCQNKPRSESLWRQCSDAAFFQDCQKKLDHKLSLDSYLLKPVQRITKYQLLLKEMLKY 785

  Fly  1433 CEESHG--EIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW--------DT 1487
            .:...|  :::|.|..:|.:.|..||:||...:...:.::.:||::::|.:|..|        ..
 Frog   786 SKNCEGAEDLQEALASILGILKAVNDSMHQIAITGYEGNLHELGKLLMQGSFNVWTEHKKGHSKV 850

  Fly  1488 KQIIR-KGRERRVFLFELYLLFAKEVKES-----NVVKYQFKSKLMTTDMGITEHIEGDETKFAV 1546
            |.:.| |..:|.:||.|..:||.|:..|:     ....|.:|..|....:||||:::||..||.:
 Frog   851 KDLARFKPMQRHLFLHEKAVLFCKKRDENGEGYEKAPSYSYKHSLNMMFVGITEYVKGDNRKFEI 915

  Fly  1547 W-TGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQRSSRDL 1610
            | ..|..:     .:::|.:.|.|..||.::|:|:       ||.......|.|..|::.::   
 Frog   916 WYNAREEV-----YIVQAPTTEVKATWVNEIRKVL-------TSQLKAHRDASHHKSAEHAN--- 965

  Fly  1611 DEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQVEIVEPPT 1675
                        ||.:....:|:...||.|                       |.:::|  |..|
 Frog   966 ------------SLPTPLPSSTSPLRNKSG-----------------------KIKKLE--ERKT 993

  Fly  1676 AGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSDMQDQSNRS 1740
              ||     .|||.            ||:...|....|...||..:..|                
 Frog   994 --EP-----LLNPD------------VSLTSVPKYLEKGKDGTVTSPTS---------------- 1023

  Fly  1741 KADALSSSTKR---RGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTP--------QKHAE 1794
              |:.:.|.||   :|||.     |.::|.:...|..|  .|:...|:..||        ..|:.
 Frog  1024 --DSSALSKKRFTLQGFSN-----LKSQKASPTSPDKK--AKRHEVKSDPTPFGLRGWNRASHSL 1079

  Fly  1795 ELAEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGP 1859
            :::|:.|:                            |:...|:                      
 Frog  1080 DVSEENNE----------------------------DWSSGED---------------------- 1094

  Fly  1860 PAFAKDAKESSGNMA-----SPGK----MDGNPLSEIEEIVKTTTEQHESNSRVDGGGGVENAST 1915
            |..:.||:|..|..|     :|||    .|....|: |.:||:....|..:....|...|:|.||
 Frog  1095 PINSSDAEEDGGGDAPEKKLTPGKYTVVADYERGSD-ELLVKSGDLVHIIHEEDGGMWYVKNLST 1158

  Fly  1916 NGHGRSHDNNDESHTAVSDKAAALKKRQ 1943
            |..|....:|..:....|..|.:|...:
 Frog  1159 NKEGLVPASNLMTLIGTSKSALSLSSSE 1186

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 9/41 (22%)
SPEC 782..997 CDD:238103 49/219 (22%)
SPEC 897..1119 CDD:238103 37/221 (17%)
SPEC 1125..1226 CDD:197544 17/100 (17%)
RhoGEF 1287..1456 CDD:279015 75/174 (43%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 36/136 (26%)
PH 1495..1580 CDD:278594 27/90 (30%)
SH3_Kalirin_1 1643..1707 CDD:212786 11/63 (17%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
mcf2lXP_012813354.1 SEC14 77..222 CDD:214706 7/20 (35%)
SPEC 353..561 CDD:238103 52/308 (17%)
RhoGEF 633..810 CDD:238091 75/176 (43%)
PH_Dbs 817..948 CDD:269934 37/142 (26%)
PTZ00108 <958..1104 CDD:240271 46/279 (16%)
SH3_DBS 1118..1171 CDD:212791 15/53 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.