DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef6

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_012825042.2 Gene:arhgef6 / 100489192 XenbaseID:XB-GENE-949773 Length:777 Species:Xenopus tropicalis


Alignment Length:622 Identity:134/622 - (21%)
Similarity:229/622 - (36%) Gaps:172/622 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  1051 EQKEAFLKACTLAR---------RTAETF------LKYANRSQQCYQYKGNCEGHVKSKLDKLLT 1100
            |..:.|||||:..|         .|.|.|      |...||:.:.......|.|.        |:
 Frog    68 ENIKEFLKACSALRVELFDPVDLYTGENFSKVLSTLSAVNRATENPTSGRPCSGR--------LS 124

  Fly  1101 QENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEH 1165
            |.:           |:..|.|.               |:...|.|:|     :.|.:::.|....
 Frog   125 QSH-----------SIPACSQI---------------NSQGTYCSTR-----VLKRQSKALDMTG 158

  Fly  1166 NEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCEQLEKSLG 1230
            |  .|.....:.|.....|..|.|                              |:|:  ..::.
 Frog   159 N--GSCQLVVKARFNFNQQNEDEL------------------------------SFCK--GDTIY 189

  Fly  1231 MSQQQLLLGSDG---NSSISSSSGDRHSDPTLEAKLNSSNKENKEIN--EEKRKSARRKEFIMAE 1290
            :|:.:     ||   ..:::..||...|:...|.|.|......|.:.  |..:.:......::..
 Frog   190 VSRVE-----DGGWWEGTLNGKSGWFPSNYVKEFKSNDKPLSPKAVKACETAQLTKNYYTVVLQN 249

  Fly  1291 LMQTERAYVNDLATCIKCFLEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETM 1355
            :::|||:|..:|...:..:|...::...:.:..:..   :.||.:||..|.|.: .:.||:...:
 Frog   250 ILETERSYAKELQLLLSTYLRPLQSHDKISTVDVSS---LLGNFEEICTFQQTL-CQALEECAKL 310

  Fly  1356 PED---VGHCFVTWASKF-DMYVHYCKNKPTSNNLLVQHG---GSFFEELQRRLEVDHPLPAYLI 1413
            ||:   ||.|.:...::| .:|:.||.|.|.:.::|.|..   |:|.|      ....|:|..|:
 Frog   311 PENHQKVGGCLLNLFNQFMSLYLSYCSNHPMAVHVLTQQSDELGTFME------NQGAPVPGILM 369

  Fly  1414 ------KPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLLENC-DVSVD 1471
                  ||..|:.||..||::|....||:|.:.|:.|        ||..|.. :|:..| |:...
 Frog   370 LTTSLSKPFIRLEKYVTLLQELERHMEEAHPDHKDIL--------KATAAFK-TLVTQCQDLRKR 425

  Fly  1472 KLGEV-VLQDAFQAWDTKQIIRKG-----------------RERRVFLF--ELYLLFAKEVKESN 1516
            |..|: :|.::.|.|:.:.|...|                 :|.|.|:.  ...|:.:...:.|.
 Frog   426 KQLELQILSESIQGWEGEDIKTLGTAVFMSQVMVQCGTNEEKEERYFMLFPNALLMLSASPRMSG 490

  Fly  1517 VVKYQFKSKLMTTDMGITEHIEGDETK--FAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREV 1579
            .:   ::.||..|.|.:.:..|.|.|.  |.:   ...|:.  |||:...:....|.|::.|..:
 Frog   491 FI---YQGKLPLTGMSVVKLEENDTTNHGFEI---AGTMIE--RIVVYCNNSHDCQEWLEHLHRL 547

  Fly  1580 MQET------C----FSGTSLTLPKS-PAKHSGSSQR 1605
            .:.|      |    .:.||||..|. |..|...:.|
 Frog   548 TKGTGSHASLCKTQSLTSTSLTERKQLPPSHYSVTPR 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103 18/82 (22%)
SPEC 1125..1226 CDD:197544 14/100 (14%)
RhoGEF 1287..1455 CDD:459876 47/180 (26%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 31/150 (21%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2121 CDD:459876
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
arhgef6XP_012825042.2 CH_alphaPIX 1..117 CDD:409114 13/48 (27%)
RhoGEF67_u1 115..161 CDD:465201 14/86 (16%)
SH3_alphaPIX 163..220 CDD:212993 13/93 (14%)
RhoGEF 243..420 CDD:238091 50/195 (26%)
PH_Cool_Pix 452..549 CDD:269932 20/104 (19%)
RhoGEF67_u2 583..681 CDD:465200 1/2 (50%)
betaPIX_CC 694..774 CDD:465158
Blue background indicates that the domain is not in the aligned region.

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