DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef25a

DIOPT Version :10

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_009295232.2 Gene:arhgef25a / 100331456 ZFINID:ZDB-GENE-100728-4 Length:732 Species:Danio rerio


Alignment Length:587 Identity:170/587 - (28%)
Similarity:276/587 - (47%) Gaps:105/587 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly  1693 AAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSD------MQDQSNRSKADALSSSTKR 1751
            ||..||.:..||...||      ..:.::|.:|.||::|.      :.:...:..|.|..|:...
Zfish    83 AAGSEGSISTSVASLPP------QASGSSAPNSPGSRRSVSTLKKWLTNPVRKLSAGAAGSAKGE 141

  Fly  1752 RGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQPGASPATVLPSSQ 1816
            |        .:...:|...||.::      |.:.|.:||...|:.             |:||.. 
Zfish   142 R--------QVRRLEGKPPPPPTR------SSQELGSPQSTEEQF-------------TILPGI- 178

  Fly  1817 FPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKESSGNMASPGKMDG 1881
                          |.|.:.:.||    |.....:|.|:.:  .:|..|:.:.|..:..      
Zfish   179 --------------DKELEWKDGL----PALGDCDPGLLQS--YSFQSDSPQGSTTLGQ------ 217

  Fly  1882 NPLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRSHDNNDESHTAV---SDKAAALKKRQ 1943
                  .:|.:.|::|               |..||.....||:.:|....   .|:.:||:|..
Zfish   218 ------TQISQCTSQQ---------------ADDNGSVLMDDNSSQSSACADTEEDRKSALEKSM 261

  Fly  1944 CVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFL 2008
            .|..||:.||:.||.||..||.|||..:|...    :|||:| ||.|:||.||..||:||:|:||
Zfish   262 YVLNELIETEKLYVADLGLIVEGYMATMNVKG----IPEDMK-GKDKIVFGNIHQIYDWHKDYFL 321

  Fly  2009 RALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLSNL 2072
            ..|..|...|..|..|..:...:..:|..||.|||.||:|||.:.: ||:.::|:|||||.|::|
Zfish   322 AELEKCVAEPERLAQLFIKHERRLHMYVVYCQNKPKSEHIVSEYIETYFEELKQQLGHRLQLNDL 386

  Fly  2073 IIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEI 2137
            :|||||||.||:||:|:..|....||:  :...|::|.:.|..|.|..||||.|.| ||.|:|:|
Zfish   387 LIKPVQRIMKYQLLLKDFHKYYTKAGM--DTEELEKAVEVMCFVPKRCNDMMNVGR-LQGFEGKI 448

  Fly  2138 TAQGSLLMQGPMNCVVDAA---QKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHM 2199
            ||||.||.|.........:   .:.:|.:||||:|::||::....|..::.|.:.:::.|:::.:
Zfish   449 TAQGKLLQQDTFTITEQDSSILSRAKERRVFLFEQLVIFSEPIDRKKGFSLPGYIFKNSIKISCL 513

  Fly  2200 QMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPLSTK 2261
            .::...|   .||.:.|.......:..:..::|.:....|...:::||:.|.:.:..|.:|:..:
Zfish   514 GVEACVDGDPNRFALTSRGADGSTVRYVLYSSSPDICMAWVSDVSQILETQRNFLNALQSPIEYQ 578

  Fly  2262 NK 2263
            .:
Zfish   579 RR 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1455 CDD:459876
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
SH3_Kalirin_1 1643..1707 CDD:212786 6/13 (46%)
RhoGEF 1945..2121 CDD:459876 79/176 (45%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 34/135 (25%)
arhgef25aXP_009295232.2 None
Blue background indicates that the domain is not in the aligned region.

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