DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef25

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_012811994.1 Gene:arhgef25 / 100170494 XenbaseID:XB-GENE-6084380 Length:753 Species:Xenopus tropicalis


Alignment Length:639 Identity:178/639 - (27%)
Similarity:281/639 - (43%) Gaps:156/639 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  1735 DQSNRSKADALSSSTKRRGFSGRNWLPLMNRKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQ 1799
            ||...:.||.|.|.    |.....|||       |..|          |::....:...|...::
 Frog    12 DQMLGAMADILGSF----GLPSHQWLP-------DSAP----------EQSRNEEKTDGENSPDE 55

  Fly  1800 QNQQPGASPATVLPSSQFPSSTQHPGGA------------GAGDYEPDEEVGLELPPPMKPIQEP 1852
            :.:||...|.......|.|:.:..||..            |...:...||             |.
 Frog    56 EEEQPNVDPQHTASGLQVPTDSTCPGMGRTRRLSDFRAWFGENFFHTSEE-------------ES 107

  Fly  1853 HLIA------NGPPAFAKDAKESSGNMASPGKMDGNPLSEIEEIVKTTTEQHESNSRVD------ 1905
            :.||      :...|..:....:|...:|||..  ..:|.:::.:.....:..|.||:|      
 Frog   108 YSIAGSDGSISASVASIQPQPSTSSAPSSPGSR--RSVSTLKKWLTNPVRKLSSGSRLDQRQSKK 170

  Fly  1906 -------GGGGVENASTNGHGRSHD---------------------------------------- 1923
                   |..|...::.:|..||.|                                        
 Frog   171 IESRPKRGVPGRRRSADDGGRRSFDLGVLRKMDEFTHPEDKGSEWKEQDHPERLPDLSILNDLLQ 235

  Fly  1924 ------NNDESHTA-VSD-----------------------KAAALKKRQCVFAELMSTEEAYVQ 1958
                  ||.:.||: :||                       |.:||:|...|..||:.||:.||:
 Frog   236 GVTTEPNNKDPHTSYLSDPTDSLASELPVTPSFPPAETEEEKKSALEKSMYVLMELIETEKMYVE 300

  Fly  1959 DLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGP 2023
            ||.:||.|||..:|...    :|||:| ||.|:||.||..|::||:|:||..|:.|.:.|..|..
 Frog   301 DLRQIVEGYMATMNTQG----IPEDMK-GKDKIVFGNIHQIFDWHKDYFLSELQKCLEDPNRLAI 360

  Fly  2024 LIKRSATKFALYYTYCSNKPLSEYIVSAHYQ-YFDSIRQKLGHRLDLSNLIIKPVQRITKYELLI 2087
            |..:...:..:|..||.|||.||:|||.:.. ||:.:||:|.|||.|::|:|||||||.||:||:
 Frog   361 LFIKHERRLHMYVVYCQNKPKSEHIVSEYIDTYFEELRQQLSHRLQLNDLLIKPVQRIMKYQLLL 425

  Fly  2088 KEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCV 2152
            |:.:|....||  ::...|::|.:.|..|.|..||||.:.| ||.|:|:|||||.||.|...  :
 Frog   426 KDFLKYYSKAG--QDTSELEKAVEVMCFVPKRCNDMMNLGR-LQGFEGKITAQGKLLQQDTF--L 485

  Fly  2153 VDAAQ-----KHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQLNHMQMKELGD---CRF 2209
            |:..:     :.:|.:||||:|||||::....|..::.|.:.:::.|:::.:.::|..|   |:|
 Frog   486 VNEQESSFLTRCKERRVFLFEQIIIFSEPIDKKKDFSLPGYIFKNSIKISCLGIEESIDNDPCKF 550

  Fly  2210 QIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNPLSTKNK 2263
            .:.|.......:..|.||::||....|...:.:||:.|.:.:..|.:|:..:.:
 Frog   551 VLTSRGADRSLVRYILQASTQEIRLAWIKDIGQILESQRNFLNALQSPIEYQRR 604

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103
SPEC 782..997 CDD:238103
SPEC 897..1119 CDD:238103
SPEC 1125..1226 CDD:197544
RhoGEF 1287..1456 CDD:279015
PH1_Kalirin_Trio_like 1462..1584 CDD:270060
PH 1495..1580 CDD:278594
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015 78/177 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 42/137 (31%)
arhgef25XP_012811994.1 SH3-RhoG_link 103..>214 CDD:406906 21/125 (17%)
RhoGEF 287..457 CDD:395496 78/176 (44%)
PH2_Kalirin_Trio_p63RhoGEF 462..601 CDD:270061 43/141 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 148 1.000 Domainoid score I4422
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5215
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.030

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