DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment trio and trio

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_012819807.1 Gene:trio / 100170157 XenbaseID:XB-GENE-922516 Length:3085 Species:Xenopus tropicalis


Alignment Length:2357 Identity:1023/2357 - (43%)
Similarity:1453/2357 - (61%) Gaps:230/2357 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
            |..:|.::|.:|:|:|.:|:||||:||||:|.|||....||::.||||||:|||..|||:.....
 Frog    53 DELKAMEVLPILKEKVAYLSGGRDKRGGPVLTFPARSNHDRIRQEDLRRLISYLACIPSEEVCKR 117

  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131
            |||||:||||:.  ..::|.:||:|||.|...||..:||||||||||||.:..|.|::|||:.||
 Frog   118 GFTVIVDMRGSK--WDSIKPLLKILQESFPCCIHVALIIKPDNFWQKQRTNFGSSKFEFETSMVS 180

  Fly   132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196
            :|.|.|:|:..|||.:|||...|:|::|.:.|:|.|||...|..|..|:::|||.|...:..:|:
 Frog   181 LEGLTKVVDPSQLTPEFEGCLEYNHEEWIEIRVAFEDFINNATHMLSRLEELQEMLAIKELPQDL 245

  Fly   197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
            ..||:.|:.|::|:|::.|.||||||::|:|||..|                           |.
 Frog   246 EGARNMIEEHSQMKKRVIKAPIEDLDLEGQKLLQTI---------------------------QS 283

  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            |....:..|..||.|:...:.|....::.:|:.::.|..:|..:|||||||||.||||||.||||
 Frog   284 SDSFPKKNSSSGNADLQNLLPKVSTMLDRLHSTRQHLHQMWHMRKVKLDQCFQLRLFEQDAEKMF 348

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            |||.||:.:|..||.:||...:.|..||.:|..||:..|||.|||.||::||.||:||.|||:|.
 Frog   349 DWITHNKGLFLTSYTDIGTRNNHAMELQTQHNHFAMNCMNVYVNISRIMSVANRLVESGHYASQQ 413

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456
            ||.:|.:|::.||.|||.||||:.:|.:|.:||.|||||..:|.||..|| ....|||::|.||.
 Frog   414 IKQIANQLEQEWKAFAAALDERSTLLDMSAMFHQKAEQYMGNVDSWCKAC-GEVDLPSELQDLED 477

  Fly   457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521
            ||..||.:||.:..||:||....|.||.:|       .:|..||..|....|             
 Frog   478 AIHHHQGIYEHITLAYSEVSQDGKSLLDKL-------QRPLTPGSSDSLTAS------------- 522

  Fly   522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586
             |:||:...|||..||::|.|.|.||..|...::||||.|.|.:||:||:|||||::||||.||.
 Frog   523 -ANYSKAVHHVLDAIHEVLHHQRQLENIWQHRKVRLHQRLQLCVFQQDVQQVLDWIENHGEAFLS 586

  Fly   587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651
            |:||:|::.|:||..|..|::||.||||||:||.|||.||::||::||.||.|||..|.:||.::
 Frog   587 KHTGVGKSLHRARALQKRHEDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYQAAHQLEDRI 651

  Fly   652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716
            ..|..|||||:..|||:|.|::|.|::..|::.|:.::..|   :..|::|.::.:::::.: ||
 Frog   652 QDFVRRVEQRKVLLDMSVSFHSHVKELWTWLEDLQKELLDD---VYAESVEAVQDLIKRFGQ-QQ 712

  Fly   717 ESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVELEELWSARKFRA 777
            ::::...:..|.:||.|:|::|....:.|    ..||..:|..|::|::.:.::|||:..||.:.
 Frog   713 QTTLQFTVNVIKEGEDLIQQLRDSAISSNKTPHNSSINHIETVLQQLDEAQSQMEELFQERKIKL 777

  Fly   778 DLILRLRYFERDARLLSVQMEMWSEEL--QHADL-SRDYQKAEQLIRMHNESVTEIQNATYEVVQ 839
            :|.|:||.|||||..:...:|.|::||  |..|. :.|...|||.::.|.:....:.|.|::|:.
 Frog   778 ELFLQLRIFERDAIDIISDLESWNDELSQQMNDFDTEDLTLAEQRLQHHADKALTMNNLTFDVIH 842

  Fly   840 QGQDLLQL---FENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQF 901
            |||:|||.   .:|:|...:.|.......|::.||:||.|::.:|:..:|..|..|||.|||...
 Frog   843 QGQELLQYVNEVQNSGVELLCDRDVDMATRVQDLLEFLHEKQQELDLAAEQHRKHLEQCVQLRHL 907

  Fly   902 QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSAVQVKYRADALINA 966
            |.:..||:.||||||:||.|..:|.:||||||||::.|||||.||||||.||:||:.:|:|::.|
 Frog   908 QAEVKQVLGWIRNGESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQA 972

  Fly   967 NHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCD 1031
            ||||...|.:.::.|...||||:...|:|.|||.||:.||||:|||||||:|||:|||||:||| 
 Frog   973 NHYDMDMIRDCAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYKREEDWC- 1036

  Fly  1032 GGGGSDK------AQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEG- 1089
              ||:||      ...:..:||||.|||||||||||||||.|:.||||.:|:..      |..| 
 Frog  1037 --GGADKLGPNSETDHVTPMISKHLEQKEAFLKACTLARRNADVFLKYLHRNSV------NMPGM 1093

  Fly  1090 --HVKSK-------LDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLS 1145
              |||:.       |::|..:||:||.||||||:.||.|||:|:||||||||:|||.:.||.|:|
 Frog  1094 VTHVKAPEQQVKNILNELFQRENRVLHYWTLRKRRLDHCQQYVVFERSAKQALEWIQDNGEFYIS 1158

  Fly  1146 SRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQR 1210
            :.:: .|.:.:.|:.|||||.||:.|||:|:|||||||||||...|||||||::||:.|.:||:|
 Frog  1159 THTS-TGSTIQHTQELLKEHEEFQITAKQTKERVKLLIQLADGFCEKGHAHAAEIKKCVTAVDKR 1222

  Fly  1211 YKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSS-------ISSSSGDRHSDPTLEAKLNSSNK 1268
            |:|||.||:.|...|||:||:|       ||..||       |.:::      |..|.||..:  
 Frog  1223 YRDFSLRMEKYRTSLEKALGIS-------SDSKSSKSLQLDIIPATA------PGSEVKLRDA-- 1272

  Fly  1269 ENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQEDVIFG 1332
             ..|:||||||||||||||||||:|||:|||.||..|:..:|.|..:| :.:|..::.:|.:|||
 Frog  1273 -THELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKEHIIFG 1336

  Fly  1333 NIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEE 1397
            |::||:.||..|||:||||||.:||||||||||||.||.|||.||||||.|..|:::..|::|:|
 Frog  1337 NMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQMYVSYCKNKPDSTQLILEQAGTYFDE 1401

  Fly  1398 LQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSL 1462
            :|:|.|:.:.:.:|||||||||||||||||:||:||||..||||:||||||:|||:||||||||:
 Frog  1402 IQQRHELVNSISSYLIKPVQRITKYQLLLKELLTCCEEGKGEIKDGLEVMLSVPKRANDAMHLSM 1466

  Fly  1463 LENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKESN-VVKYQFKSKL 1526
            ||..|.:::..||::||::||.||.|.:|||||||.:||||:.|:|:||||:|: ..||.:||||
 Frog  1467 LEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYIYKSKL 1531

  Fly  1527 MTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC------- 1584
            .|:::|:|||:|||..|||:|.||:| .||.:||||.:|:|.||.|:|.:|||:|:..       
 Frog  1532 FTSELGVTEHVEGDPCKFALWVGRTP-TSDNKIVLKGSSIENKQDWIKHIREVIQDRTIHLRGAL 1595

  Fly  1585 -----FSGTSLTLPKSPAKHSGSSQRSSRDLDEQLT-ENDHDRCSLASFGSGNTTDSDNKLGNQE 1643
                 ...|:....:.|||..|      .|||.|.. .:..|..|:||..|.||.|||...|..|
 Frog  1596 KEPIHIPKTAAATKQKPAKRDG------EDLDSQGDGSSQPDTISIASRTSQNTLDSDKLSGGCE 1654

  Fly  1644 ATWVVADYIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVL--- 1705
            .|.|:.|:.|.: ||||::.:||.||::| .....||:||||..   |.:...|||||.|.|   
 Frog  1655 LTVVIHDFTACN-SNELTIKRGQTVEVLE-RHHDRPDWCLVRTT---DRSPAAEGLVPSSSLCIA 1714

  Fly  1706 -----KPPPG--SHKHGSGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWL--P 1761
                 ....|  :||.....::|.||...|..| :|.....:::   |...||.|.:.|.||  |
 Frog  1715 HSRSSMEMEGIFNHKDSLSVSSNDASPPASVIS-LQPHMIGAQS---SPGPKRPGNTLRKWLTSP 1775

  Fly  1762 LMN-----------------------RKGTDKPPSSKPLVKKPSEKNLRTPQKHAEELAEQQNQQ 1803
            :..                       ||.||...      :|.|:.:..|||   :|..|::.:.
 Frog  1776 VRRLSSGKADGHVKKLAHKHKKSREVRKNTDSGS------QKDSDDSAATPQ---DETIEERVRN 1831

  Fly  1804 PGASPATVLPSSQFPSSTQHPGGAGAGDYEPDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKE 1868
            .|.|..|:..||   ||.....|...|:..||   .:.||||| .||:..|:...    ::|.|.
 Frog  1832 EGLSSGTLSKSS---SSGMQSCGEEEGEEGPD---AVPLPPPM-AIQQHSLLQPD----SQDDKT 1885

  Fly  1869 SSGNMASPGKMD----GNPLSEIEEIVKT--TTEQHESNSRVDGGGGVENASTNGHGRSHDNNDE 1927
            ||..:..|...:    ...:|.|||:||:  ..|...|:.:||.|    ::|:.....|..:...
 Frog  1886 SSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLQVDQG----DSSSPSFNPSDTSLLS 1946

  Fly  1928 SHTAVSD----KAAALKKRQCVFAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGK 1988
            |.:.:.:    |:::||:|..|..||:.||..||:||..:|.|||..:....    :|:|:| ||
 Frog  1947 SSSPIDEMEEKKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG----VPDDMK-GK 2006

  Fly  1989 MKLVFNNIKDIYEWHRDFFLRALRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHY 2053
            .|:||.|:..||||||||||..|..|...|..|..|..:...:..:|..||.|||.||:|||.:.
 Frog  2007 DKIVFGNLHQIYEWHRDFFLGELERCLDEPERLASLFVKHERRLHMYIVYCQNKPKSEHIVSEYI 2071

  Fly  2054 Q-YFDSIRQKLGHRLDLSNLIIKPVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVV 2117
            . ||:.::|:|||||.|::|:|||:|||.||:||:|:.:|.::.|.:  :|..|:.|.:.|.:|.
 Frog  2072 DTYFEDLKQRLGHRLQLTDLLIKPIQRIMKYQLLLKDFLKYSKKACI--DVAELERAVEVMCIVP 2134

  Fly  2118 KTVNDMMVVLRSLQDFDGEITAQGSLLMQGPMNCVVDAA---QKHRELQVFLFQQIIIFADIEKT 2179
            |..||||.|.| ||.|||:|.|||.||:|.........|   .:.:|.:||||:||:||::....
 Frog  2135 KRCNDMMNVGR-LQGFDGKIVAQGKLLLQDTFLVTEQDAGLLPRCKERRVFLFEQIVIFSEPLDK 2198

  Fly  2180 KNQYASPIFKYRSHIQLNHMQMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLN 2241
            |..|::|.|.::::|:::.:.::|..|   |:|.:.|......||.:: .::|......|...:|
 Frog  2199 KKGYSTPGFLFKNNIKVSCLSLEECVDSDPCKFALLSRSADSTEMFVL-HSSSPGVRQLWIHEIN 2262

  Fly  2242 KILQQQNDLIFMLSNPL 2258
            :||:.|.:.:..|::|:
 Frog  2263 QILENQRNFLNALTSPI 2279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706 77/138 (56%)
SPEC 314..>468 CDD:238103 84/153 (55%)
SPEC 563..778 CDD:238103 89/218 (41%)
SPEC 782..997 CDD:238103 96/220 (44%)
SPEC 897..1119 CDD:238103 128/237 (54%)
SPEC 1125..1226 CDD:197544 59/100 (59%)
RhoGEF 1287..1456 CDD:279015 104/169 (62%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 67/122 (55%)
PH 1495..1580 CDD:278594 49/85 (58%)
SH3_Kalirin_1 1643..1707 CDD:212786 28/71 (39%)
RhoGEF 1945..2122 CDD:279015 77/177 (44%)
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061 42/135 (31%)
trioXP_012819807.1 SEC14 64..199 CDD:214706 74/134 (55%)
SPEC 215..440 CDD:238103 91/224 (41%)
SPEC 336..561 CDD:238103 108/224 (48%)
SPEC 562..778 CDD:238103 91/215 (42%)
SPEC 782..1009 CDD:238103 98/236 (42%)
SPEC 903..1132 CDD:238103 124/234 (53%)
SPEC 1138..1238 CDD:197544 59/109 (54%)
RhoGEF 1289..1459 CDD:238091 90/177 (51%)
PH1_Kalirin_Trio_like 1466..1588 CDD:270060 80/122 (66%)
SH3_Kalirin_1 1654..1713 CDD:212786 24/59 (41%)
SH3-RhoG_link 1710..1967 CDD:293215 85/297 (29%)
RhoGEF 1965..2138 CDD:238091 74/177 (42%)
PH2_Kalirin_Trio_p63RhoGEF 2143..2281 CDD:270061 48/143 (34%)
SH3_Kalirin_2 2543..2601 CDD:212787
I-set 2673..2764 CDD:254352
Ig 2687..2764 CDD:299845
STKc_Trio_C 2776..3038 CDD:271015
S_TKc 2784..3038 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 230 1.000 Domainoid score I2405
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20847
Inparanoid 1 1.050 1713 1.000 Inparanoid score I69
OMA 1 1.010 - - QHG46230
OrthoDB 1 1.010 - - D4513at33208
OrthoFinder 1 1.000 - - FOG0002562
OrthoInspector 1 1.000 - - otm49408
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1686
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
109.980

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