DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and arhgef40

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_001919604.4 Gene:arhgef40 / 100151026 ZFINID:ZDB-GENE-110623-2 Length:1752 Species:Danio rerio


Alignment Length:1381 Identity:274/1381 - (19%)
Similarity:454/1381 - (32%) Gaps:452/1381 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   442 QASQPLPSDIQSLET-AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHR 505
            :|:||:....||.|. .:.|:.:..||.....|:..|.:|      |...|.|...     |||.
Zfish   615 KATQPISHSSQSEEAPQLSTNSTGCEASSDDKTDAKSKAK------DGESQSCTSS-----PDHS 668

  Fly   506 KNSNNGSFNKYERQNPAADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDV 570
            :|.              ...|:.|:||.:....  :|.:.|:               |.|.|.  
Zfish   669 QNE--------------VGLSQFAAHVESTSPP--THLKDLD---------------LNLLQS-- 700

  Fly   571 KQVLDWLKNHGEVFLRKNTGIGRNFHKARVYQTSH---DNFENVAQNTYSNAQKLLAAADELAR- 631
                      |::.|   ||......:|.|...||   |.:      |.:...|:|:....:.| 
Zfish   701 ----------GKLIL---TGTMDRLGRALVVTESHLPEDGW------TTNEMIKVLSCYYTITRP 746

  Fly   632 ------------SGEADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDK 684
                        |.::.|:|:...|.:|      |.   ||....|| :|:..|.|.|.:     
Zfish   747 MVKEKGLTVIVDSRKSAPSELCLSALKL------FK---EQAATGLD-SVLILTEESDES----- 796

  Fly   685 LRTDVSTDETRLSQENLEGIER-------ILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLEY 742
                        :|..|||||.       ||||:. |:|.               |.:||.. ::
Zfish   797 ------------TQPYLEGIEMHTVRGTGILQQFV-DKQH---------------LPREMGG-DF 832

  Fly   743 ADNTGSIAALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHA 807
            ..:.........:||:|.      |...||.....|            .|.|::.|...:.::..
Zfish   833 NHSHDDWLTFRLSLEQLT------ERCESALTLLGD------------ALQSMETEPLPDCIKTV 879

  Fly   808 DLSRDYQKAEQLIR--MHNESVTEIQ-----------NATYEVVQQGQDLLQLFENAG--FISMA 857
            .||.|  |..||:.  :.::.:||:|           |.|..:.|:..|....|....  :.|:.
Zfish   880 PLSVD--KHRQLMTGILTDQRLTELQQRGGAWLAGLANGTSGLAQKSPDCKAAFAVTSDLYDSVD 942

  Fly   858 DATH-------------TAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQ--------- 900
            ||.|             .|..|:..|:|.|.:.|.|:|::.:..:...:..:.|.:         
Zfish   943 DALHRLVRSSNQRSRDLEALGRLAALVDKLDKCERDVEQIQDQLKDYKDPPLSLSRLTLKQHKFR 1007

  Fly   901 -FQNDA-----------NQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIEKTHTSA 953
             |:..|           .:|.||.....:.|.|      .|::...:|:........:....|..
Zfish  1008 SFRESAMDLHSETLVLLAEVESWSELDWSGLAA------VLEKLPPVREKVRDMSHCLSDRWTQL 1066

  Fly   954 VQVKYRADALINANHY--------------DPLS-----------------IDEISDDVTKKWQQ 987
            ...:.....|..|:.:              .|||                 :|.....:...|.|
Zfish  1067 DNTQRLLSTLTEASQWCDVVSSSSPSSSSTSPLSSLPPIPPSRFQDARALALDLGGGALLDLWSQ 1131

  Fly   988 LV-----TYAEERHKLVTASINF--------------YKTAEQVCSVLDSLEREYKREDDWCDGG 1033
            .:     |.||.:.:::.|....              ...|....|.|..||.|.  |.|||.||
Zfish  1132 TLERYQKTLAEFKSRILQAERGSSVAQGQEPDLGGRGRTPAPSSTSSLGDLEGEI--EPDWCPGG 1194

  Fly  1034 -GGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDK 1097
             ||.....::..|.                             |.|.|...|   .|..|.|   
Zfish  1195 EGGMQSWGSLASLF-----------------------------RPQNCSTLK---IGEEKKK--- 1224

  Fly  1098 LLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEE-TEGL 1161
                                                |.::..|..:|   .||:..:|:. |:..
Zfish  1225 ------------------------------------EGVNPGGGKFL---QNLLHPAKKNPTDAP 1250

  Fly  1162 L------KEHNEF-----------RSTAKETRERVKLLIQLA--------DSLVEKGHAHASDIK 1201
            |      |.|..|           .:|:|.|.........|:        |.::..|.|.|  :.
Zfish  1251 LPPKPPRKRHPSFDLQALLAPRRAGATSKPTESTSGQSSPLSWLGRKAMTDPILTAGVAAA--VP 1313

  Fly  1202 QW---------------VASVDQRYKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSISSSSG 1251
            .|               :..|:...|:.::.           .|.::|.:||     |.....:|
Zfish  1314 GWRDPAAGGEAGGGGVLIRGVEVSSKEVADH-----------TGFTRQHVLL-----SRTERGTG 1362

  Fly  1252 DRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG 1316
            ...:..|.::||...                     ...|:.|||.||..|....:.:|....: 
Zfish  1363 LERAGVTAQSKLYLQ---------------------WCRLVSTERQYVAVLKGVEENYLPLLES- 1405

  Fly  1317 KSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKP 1381
            ..|||||.|:.:.:|.|.|.:..||.::.|..:|...:.......||..:..:|.:|..|.:.:|
Zfish  1406 PDVPSALRGKAESLFCNWKSLSAFHSQLLLPAMEGALSQTLQQTDCFTKYKDQFLLYSQYIRMRP 1470

  Fly  1382 TSNNLLVQHGGSFFE-ELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLE 1445
            .::.|::.....||: :|...|....|.|..|..|:||:.:|...|::|..        :..|.:
Zfish  1471 ETDALIISQAADFFKMKLCSSLVPAPPFPQCLSAPLQRLQQYTQALEELAG--------LNPGSD 1527

  Fly  1446 VMLNVPKKAN----DAMHLSLLENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRE-----RRVFL 1501
            ..|::.|.|:    |.....|:..|.:.|.:.|::|.|...      .:...||.     |.|||
Zfish  1528 SALSIIKHAHRHGEDLRASELISGCPIPVAERGDLVRQGEL------CVCGGGRRKKTGVRNVFL 1586

  Fly  1502 FELYLLFAKE--VKESNVVKYQFKSKLMTTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKAT 1564
            ::.:::|.|.  ....|.| |.||..:.|.:||:|:.:..|..:|.||..::....|| :.|:..
Zfish  1587 YQNFMIFTKHKTPNPGNSV-YSFKHSIKTGEMGLTQSVGEDGLRFEVWVRQASRTRDC-LTLQTA 1649

  Fly  1565 SLETKQIWVKKLREVMQETCFSGTSLTLPKSPAKHSGSSQR--------SSRDLDEQLTENDHDR 1621
            |.:.::.|...:.:::.......|.|.|.:|..  .|.|.:        .|.:||...:.||..:
Zfish  1650 SHQDRESWTHDIAQLLWTHAMHNTELCLKESLC--MGISSKLLLDVTGAQSAELDSSSSLNDRVQ 1712

  Fly  1622 CSLASFGSGNTTDSDN 1637
            .|.:...|..:...|:
Zfish  1713 SSCSDSSSVGSMKEDS 1728

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103 8/26 (31%)
SPEC 563..778 CDD:238103 51/237 (22%)
SPEC 782..997 CDD:238103 51/299 (17%)
SPEC 897..1119 CDD:238103 45/293 (15%)
SPEC 1125..1226 CDD:197544 22/141 (16%)
RhoGEF 1287..1456 CDD:279015 45/173 (26%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 32/128 (25%)
PH 1495..1580 CDD:278594 25/91 (27%)
SH3_Kalirin_1 1643..1707 CDD:212786
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
arhgef40XP_001919604.4 RhoGEF 1381..1519 CDD:295373 40/138 (29%)
PH-like 1534..1673 CDD:302622 35/146 (24%)
PH 1562..1661 CDD:278594 28/106 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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