DRSC/TRiP Functional Genomics Resources

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Protein Alignment trio and mcf2l2

DIOPT Version :9

Sequence 1:NP_651960.2 Gene:trio / 43974 FlyBaseID:FBgn0024277 Length:2263 Species:Drosophila melanogaster
Sequence 2:XP_021335410.1 Gene:mcf2l2 / 100149630 ZFINID:ZDB-GENE-100812-1 Length:1284 Species:Danio rerio


Alignment Length:1466 Identity:341/1466 - (23%)
Similarity:568/1466 - (38%) Gaps:329/1466 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   510 NGSFNKYERQNPAADYSEGASHVLAVIH--QILSHHRTLEAKWHQERLRLHQTLALR---LFQED 569
            ||......|.:....||:|||..|..|.  ::.|:||.|       .:.|...||.|   :.|::
Zfish     2 NGYQTAQSRCSVCGLYSQGASFTLVRISAGEMESYHRFL-------GVCLETELATRRNEIMQQE 59

  Fly   570 VKQVL--DWLKNHGEVFLRKNTGIGRNFHKARVY-------QTSHDNFENVAQNTYSNAQKLLAA 625
            ::.:|  |.::.....|...:.|.|:.......:       :.|.::|.||.  ||..:...:.|
Zfish    60 IRPLLAVDIIEQLHRQFALLSGGRGQEGSPIITFPEFSGFNEVSDEDFINVV--TYLTSIPSMDA 122

  Fly   626 AD-----ELARSGEADPNEIYSVARELELQVGSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKL 685
            |.     .|.|..:...:.|.|:||    ..|||.       ..|.:.::.     ..:.::.:.
Zfish   123 ASIGFIIILDRRKDKWNSAIASLAR----IAGSFP-------GNLQLVLVL-----KPSRFLQRA 171

  Fly   686 RTDVSTDETRLSQENLEGIERILQQYQRDQQESSVNVCLTTISQGEALLQEMRSLE-YADNTGSI 749
            ..|||                  .:..||..:..|.:         .:|..:..|. |.|.....
Zfish   172 IADVS------------------MRLHRDDFKLKVPI---------VMLNSLSDLHGYIDKGQLT 209

  Fly   750 AALEATLEKLNKQKVELEELWSARKFRADLILRLRYFERDARLLSVQMEMWSEELQHADLSRDYQ 814
            ..|..||:..:.|       |...:      ..:..|....:..:..::.:..:|...:|..|.|
Zfish   210 CDLGGTLDYCHSQ-------WIHHR------TAIENFALTVKSTAQMLQQFGTDLAETELPNDVQ 261

  Fly   815 KAEQLIRMHNESVTEIQNATYEVVQQGQDLL-----QLFENAGFISMADATHTAQARIEYLLDFL 874
            ..:.|:..|.|...::::.....|:||..||     |..:....|...|.... |..:|.||..|
Zfish   262 CTKDLLITHTEKHDKLKDELKLAVKQGNTLLSCIKDQATKAESHILNPDEVEN-QTTVERLLAQL 325

  Fly   875 REREIDLEEMSEAKRAKLEQAVQLCQFQNDANQV-ISWIRNGEAMLVASFVTPNSLQEAEQ---- 934
            .|.|...|:.......||||.:||..|:.|..:| :|.....||:|..| .|.:.:...||    
Zfish   326 DETENAFEQFWSRHHLKLEQCLQLRHFEQDFKEVKVSLDGLSEALLGLS-DTGDCVARVEQLLGE 389

  Fly   935 LRKGHEQFQIAIEKTHTSAVQVKYRADALINANHYDPLSID----------EISDDVTKKWQQLV 989
            |:...::.|..:||....|    ...|.||.:|||   :||          .|.||.:.:     
Zfish   390 LKTLEDKAQECLEKAQLQA----QHGDQLIQSNHY---AIDSIRPKCVELRRICDDFSNE----- 442

  Fly   990 TYAEERHKLVTASINFYKTAEQVCSVLDSLEREYKREDDWCDGGGGSDKAQAIVQLISKHQEQKE 1054
              |:::..::|.|:...|..::|              :.||:.|.....:||:.:  .:.||..|
Zfish   443 --AKKKRDVLTKSLEILKRIDEV--------------NQWCESGVYLLASQAVDR--CQTQEGAE 489

  Fly  1055 AFLKACTLARRTAETFLKYANRSQQCYQYKGNCEGHVKSKLDKLLTQENQVLDYWTLRKKSLDQC 1119
            |       |.:..|.::|.|...|             .|.|.:|..|...||.            
Zfish   490 A-------ALQDIERYMKTAKEQQ-------------LSHLKELNNQYEVVLS------------ 522

  Fly  1120 QQFVLFERSAKQAIEWIHNTGEAYLSSRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQ 1184
               .|.:...:.|::.:::..|.:....::|..:|.::|..:........|:.|....::     
Zfish   523 ---ELLKSKVQTALKTLNDVQEMFEKRHASLKKLSTKQTRPVQPVAPRPESSPKRPSPKI----- 579

  Fly  1185 LADSLVEKGHAHASDIKQWVASVDQRYKDFSNRMDSYCE-----QLEKSLGMSQQQLLL--GSDG 1242
             ........|...:|            ...:||..|..|     .:.|:.|..:.:::.  |..|
Zfish   580 -PHPTPPTSHRKTTD------------NSSTNRQPSDAELAKRKNIRKAKGGIKIEVMHEGGQGG 631

  Fly  1243 NSSISSSSGDRHSDPTLEAKLNSSNKENKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIK 1307
            :|.|..:                        ||.:...:.|:..||.||::|||.||.:|.:.|:
Zfish   632 SSHILMN------------------------NETEESLSNRRSHIMNELIETERLYVEELQSIIE 672

  Fly  1308 CF---LEEFRAGKSVPSALIGQEDVIFGNIKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASK 1369
            .:   |::......:|.:|..:::|:|||:.||:.|||||||:|||.....||.||.||:....:
Zfish   673 GYAAALDDPELIYLIPPSLENKKEVLFGNLPEIYQFHQKIFLKELENSAEKPELVGTCFLKRKEE 737

  Fly  1370 FDMYVHYCKNKPTSNNLLVQHGGS-FFEELQRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCC 1433
            ..:|..||:|||.|..|..|.|.| ||:|.|:||:....|.|||:|||||||||||:||::|.|.
Zfish   738 LQIYEKYCQNKPRSEALWRQCGDSMFFQECQKRLDHKLSLDAYLLKPVQRITKYQLMLKEMLKCS 802

  Fly  1434 EESHG--EIKEGLEVMLNVPKKANDAMHLSLLENCDVSVDKLGEVVLQDAFQAW--------DTK 1488
            :...|  |::|....:|::.|..||:||...:...:.|::.||::::|.:|..|        ..|
Zfish   803 KNPEGTAELEEAQATVLDIIKSVNDSMHQIAITGFEGSLNDLGKLLMQGSFNVWTDHKKGHSKVK 867

  Fly  1489 QIIR-KGRERRVFLFELYLLFAKEVKE-----SNVVKYQFKSKLMTTDMGITEHIEGDETKFAVW 1547
            .:.| |..:|.:||:...:||.|:.:|     .....|.||..|....:||||:::||..||.:|
Zfish   868 DLARFKPMQRHLFLYHKMILFCKKREEMTDGHEKSPSYSFKHSLKMGSVGITENVKGDIKKFEIW 932

  Fly  1548 -TGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQ---ETCFSGTSL------TLPKSPAKHSGS 1602
             .||..:     .:::|.|::.|..||.::|:|:.   |.|...:.|      .:..:|.::  .
Zfish   933 YNGREEV-----YIIQAPSMDVKNTWVSEIRKVLTSQLEACREASQLHQKITENIYHAPMRN--M 990

  Fly  1603 SQRSSRDLDEQLTENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVADYIATSGSNELSVSKGQQ 1667
            .:.:.|..|....|..:.|............|:.:.||::.|......:.....||..|:.    
Zfish   991 RKTALRQSDSSSPETGYRRSDSGPNMRQKRADTSSSLGSERAALPRKRFTLQGLSNRRSLP---- 1051

  Fly  1668 VEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKPPPGSHKHGSGTAANAASSAGSQKSD 1732
               .||.             |:..:...:..|....           ||.||....:..   .|.
Zfish  1052 ---AEPA-------------PKETEVTRRFSLASTV-----------GSATAPRTKAPL---SSS 1086

  Fly  1733 MQDQSNRSKAD----ALSSSTKRRGF---SGRNWLPLMNR-KGTDKPPSSKPLV----KKPSEKN 1785
            ::.:.::.|:|    ....:||.|||   :.|:.||...: ||:.   .|||.|    .:|....
Zfish  1087 LKSKRHQIKSDPTPFGYEGATKTRGFKKETMRDSLPAERKSKGSG---GSKPAVPRSASQPGWSQ 1148

  Fly  1786 LRTPQKHAEEL---------------AEQQNQQPGASPATVLPSSQFPSSTQHPGGAGAGDYE-- 1833
            .|.|...||:.               .|.:................:.|.|.......|||:.  
Zfish  1149 RRLPSMDAEDFETIPSSAEELSISSDGEDEGHNKNGDNDRYQVQLTYESCTAQDLSVEAGDFVQF 1213

  Fly  1834 -PDEEVGLELPPPMKPIQEPHLIANGPPAFAKDAKE 1868
             .:.|.||.|...:: .|:..|:   ||...:...|
Zfish  1214 LEESENGLWLVKNLR-TQKTGLV---PPTVLQSTAE 1245

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
trioNP_651960.2 SEC14 13..152 CDD:214706
SPEC 314..>468 CDD:238103
SPEC 563..778 CDD:238103 40/232 (17%)
SPEC 782..997 CDD:238103 58/234 (25%)
SPEC 897..1119 CDD:238103 54/236 (23%)
SPEC 1125..1226 CDD:197544 13/105 (12%)
RhoGEF 1287..1456 CDD:279015 77/174 (44%)
PH1_Kalirin_Trio_like 1462..1584 CDD:270060 39/139 (28%)
PH 1495..1580 CDD:278594 28/90 (31%)
SH3_Kalirin_1 1643..1707 CDD:212786 8/63 (13%)
RhoGEF 1945..2122 CDD:279015
PH2_Kalirin_Trio_p63RhoGEF 2130..2260 CDD:270061
mcf2l2XP_021335410.1 SEC14 77..217 CDD:214706 32/184 (17%)
SPEC 348..554 CDD:238103 58/271 (21%)
RhoGEF 649..826 CDD:238091 77/176 (44%)
PH_Dbs 833..964 CDD:269934 38/135 (28%)
Mating_C 932..>1122 CDD:315419 42/230 (18%)
SH3_DBS 1188..1242 CDD:212791 13/57 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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