DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment trio and kalrna

DIOPT Version :9

Sequence 1:	NP_651960.2	Gene:	trio / 43974	FlyBaseID:	FBgn0024277	Length:	2263	Species:	Drosophila melanogaster
Sequence 2:	XP_017213230.1	Gene:	kalrna / 100148988	ZFINID:	ZDB-GENE-100921-4	Length:	2968	Species:	Danio rerio

Alignment Length:	2341	Identity:	984/2341 - (42%)
Similarity:	1444/2341 - (61%)	Gaps:	224/2341 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DGQRARDLLTLLQERVVFLTGGRDRRGGPLLCFPATPRRDRLKPEDLRRLLSYLISIPSDAAKNL 66
            :|.:|.|:|.:|:|::.|::||||:||||:|.|||....||:|.||||||::||.::||:.....
Zfish    28 EGIKASDVLPVLREKIAFVSGGRDKRGGPILTFPARSNHDRIKQEDLRRLVTYLSTVPSEDVCKR 92

  Fly    67 GFTVIIDMRGNGNCSTNVKTILKVLQEHFSANIHNVVIIKPDNFWQKQRASISSHKYKFETTTVS 131
            ||||||||||:.  ...:|.:||.|||.|.|.|...:|||||||||||:.:..|.|:.|||:.||
Zfish    93 GFTVIIDMRGSK--WELIKPLLKTLQEAFPAEICVALIIKPDNFWQKQKTNFGSAKFTFETSMVS 155

  Fly   132 IESLNKIVESHQLTGDFEGQQLYDHQQWTDARLAIEDFFWQAGDMADRIDDLQEDLNRNDFAEDV 196
            :|.|.|:|:..|||.||||...|:|::|.:.|:|:|:|...|..:..|::||||.|.:.:|..||
Zfish   156 VEGLTKLVDPSQLTDDFEGSLEYNHEEWLELRVALEEFLASAVHLLSRLEDLQETLAKKEFPVDV 220

  Fly   197 PLARHAIDHHNEMRKKITKLPIEDLDMQGKKLLAKINAMAPPGGQAPTNSGGPDMDSGPSSAGQQ 261
            ..:|..||.|.:::||:.|.|:|:||.:|::||..|.                      ||.|..
Zfish   221 EASRRLIDEHTQLKKKVMKAPVEELDHEGQRLLQCIR----------------------SSDGFS 263

  Fly   262 SQPSQQSRSVGGNPDMSAAVNKALRQIELIHTGQEKLLMLWQHKKVKLDQCFQWRLFEQDCEKMF 326
            .:     ..:.|:.|..:.|.|....::.:|:.::.|..:|..:|:|||||||.||||||.||||
Zfish   264 GR-----NCISGSADFQSVVPKIASLLDKLHSTRQHLHQMWHLRKLKLDQCFQLRLFEQDAEKMF 323

  Fly   327 DWILHNRDVFQMSYVEIGHNYSVAKSLQDEHQKFAVASMNVSVNIDRILAVAARLIESQHYAAQH 391
            |||.||:::|..|:.|||.:|..|..||.:|..||:.|||..|||:||::||:||.|:.|||||.
Zfish   324 DWISHNKELFLQSHTEIGVSYQHAVELQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYAAQQ 388

  Fly   392 IKTLAQRLDRTWKDFAAGLDERTAVLQLSVLFHHKAEQYCNSVASWAAACQASQPLPSDIQSLET 456
            ||.::.:||:.||.|||.||||:.:|.:|.:||.|:||:.:.|.:|...| :...|||::|.||:
Zfish   389 IKQISTQLDQEWKSFAAALDERSTILAMSAVFHQKSEQFLSGVETWCKMC-SEGGLPSEMQDLES 452

  Fly   457 AIRTHQSLYEAMCQAYTEVHSTSKKLLYQLDHLVQVCNQPPPPGVPDHRKNSNNGSFNKYERQNP 521
            ||..||:|||.:.||||||....|.||       .|..:|..||              ..|....
Zfish   453 AIHHHQTLYEQVTQAYTEVSQDGKALL-------DVLQRPLSPG--------------NAESLTA 496

  Fly   522 AADYSEGASHVLAVIHQILSHHRTLEAKWHQERLRLHQTLALRLFQEDVKQVLDWLKNHGEVFLR 586
            .|:||:....:|.|:|::|.|.|.||..|...::||||.|.|.:||:||:||:||::||||.||.
Zfish   497 TANYSKAVHCILDVVHEVLHHQRRLENIWQHRKVRLHQRLQLCVFQQDVQQVIDWIENHGEAFLS 561

  Fly   587 KNTGIGRNFHKARVYQTSHDNFENVAQNTYSNAQKLLAAADELARSGEADPNEIYSVARELELQV 651
            |:||:|::.|:||..|..||:||.||||||:||.|||.||::||::||.||.|||..||.||:::
Zfish   562 KHTGVGKSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRI 626

  Fly   652 GSFAERVEQRRRRLDMAVIFYTHEKDVTAWIDKLRTDVSTDETRLSQENLEGIERILQQYQRDQQ 716
            ..|..|||||:..|||:|.|:||.|::..|::.|:.::..:   :..::::.::.:::|:|: ||
Zfish   627 QDFVRRVEQRKLLLDMSVSFHTHTKELWTWMEDLQKELLEE---VCSDSVDSVQELIKQFQQ-QQ 687

  Fly   717 ESSVNVCLTTISQGEALLQEMRSLEYADN----TGSIAALEATLEKLNKQKVELEELWSARKFRA 777
            .:::...|..|.:||.|:|::|....:.|    |.|||.:|..|::|.:.:..:|||:..||.:.
Zfish   688 TATLEATLNVIKEGEDLMQQLRDSAMSSNKMPHTSSIAHIEGVLQQLEEAQGHMEELFHERKIKL 752

  Fly   778 DLILRLRYFERDARLLSVQMEMWSEEL---QHADLSRDYQKAEQLIRMHNESVTEIQNATYEVVQ 839
            |:.|:||.||:....::.:::.|:|:|   .:.....:...|||.::.|.|....:.|.||||:|
Zfish   753 DIFLQLRIFEQYTIEVTAELDAWNEDLVRQMNEYTGEEPSLAEQRLQRHAERKLAMTNMTYEVMQ 817

  Fly   840 QGQDLLQLF---ENAGFISMADATHTAQARIEYLLDFLREREIDLEEMSEAKRAKLEQAVQLCQF 901
            |||||.|..   :.:|.....:.......:::.||:||.|::.:|:..:|..:.:|||.|||...
Zfish   818 QGQDLHQYIMEVQASGIELTGEKEVDLATQVQELLEFLHEKQHELDMSAEHTQKRLEQCVQLRHL 882

  Fly   902 QNDANQVISWIRNGEAMLVASFVTPNSLQEAEQLRKGHEQFQIAIE---------KTHTSAVQVK 957
            |.:..||:.||||||:||.||.|..:||.|||||::.|||||:|||         |||.||:||:
Zfish   883 QAEVKQVLGWIRNGESMLDASMVNASSLSEAEQLQREHEQFQLAIESLFHANSLQKTHQSALQVQ 947

  Fly   958 YRADALINANHYDPLSIDEISDDVTKKWQQLVTYAEERHKLVTASINFYKTAEQVCSVLDSLERE 1022
            .:|:.::.|.|:||.:|...::.|...||||:...|:|.|||.||:.||||:|||||||:|||:|
Zfish   948 QKAEIMLQAGHFDPEAIRSCAEKVAVHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQE 1012

  Fly  1023 YKREDDWC---DGGGGSDKAQAIVQLISKHQEQKEAFLKACTLARRTAETFLKYANRSQQCYQ-Y 1083
            |:|::|||   |..|.|.:...::.|||||.|||||||||||||||.||.||||.:|:....| .
Zfish  1013 YRRDEDWCGAHDKLGSSSETDHVLPLISKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSSQGS 1077

  Fly  1084 KGNCEG---HVKSKLDKLLTQENQVLDYWTLRKKSLDQCQQFVLFERSAKQAIEWIHNTGEAYLS 1145
            ..|..|   .||:.|::||.:||:||.:||::|:.||||||:|:|||:||||:|||...||.||:
Zfish  1078 SSNTRGPEQQVKAILNELLQRENRVLHFWTMKKRRLDQCQQYVVFERNAKQALEWIEEAGEVYLA 1142

  Fly  1146 SRSNLVGISKEETEGLLKEHNEFRSTAKETRERVKLLIQLADSLVEKGHAHASDIKQWVASVDQR 1210
            :.: .:|.|.|:|:|||||:.||..:||:|:|:||:||||||:.|||||.|.:|:|:.:.:||:|
Zfish  1143 THT-CIGDSMEKTQGLLKEYEEFCISAKQTKEKVKMLIQLADNFVEKGHMHVTDLKKCLTAVDKR 1206

  Fly  1211 YKDFSNRMDSYCEQLEKSLGMSQQQLLLGSDGNSSI------SSSSGDRHSDPTLEAKLNSSNKE 1269
            |:|||.||..|...||..||:|       |:.|..:      :|.:|.       |.||..   .
Zfish  1207 YRDFSMRMGKYRCDLENVLGIS-------SEDNKDLELDIIPASLTGP-------EVKLRD---P 1254

  Fly  1270 NKEINEEKRKSARRKEFIMAELMQTERAYVNDLATCIKCFLEEFRAG-KSVPSALIGQEDVIFGN 1333
            |.|:|||||||||:||||:|||:|||:|||.||..|::.:|.|...| :.:|..:..:|.:||||
Zfish  1255 NHEVNEEKRKSARKKEFIIAELLQTEKAYVRDLHECLETYLWEMTNGVEEIPPGIANKEHIIFGN 1319

  Fly  1334 IKEIHHFHQKIFLRELEKYETMPEDVGHCFVTWASKFDMYVHYCKNKPTSNNLLVQHGGSFFEEL 1398
            |:||:.||..|||:||..||.:||||||||||||.||::||.||||||.|:.|::.|.||||:|:
Zfish  1320 IQEIYDFHNNIFLKELINYEQLPEDVGHCFVTWADKFNIYVTYCKNKPDSSQLILDHAGSFFDEI 1384

  Fly  1399 QRRLEVDHPLPAYLIKPVQRITKYQLLLKDLLSCCEESHGEIKEGLEVMLNVPKKANDAMHLSLL 1463
            |:|..:.:.:.:|||||||||||||||||:|||||||..||||:||||||:|||:||||||:|:|
Zfish  1385 QKRHSLTNSISSYLIKPVQRITKYQLLLKELLSCCEEGKGEIKDGLEVMLSVPKRANDAMHVSML 1449

  Fly  1464 ENCDVSVDKLGEVVLQDAFQAWDTKQIIRKGRERRVFLFELYLLFAKEVKES-NVVKYQFKSKLM 1527
            |..|.::|..||::|||.||.||.|.:|||||:|.:||||:.|:|:||:|:| ...||.||:||:
Zfish  1450 EGFDANLDVQGELILQDTFQVWDPKSLIRKGRDRHLFLFEISLVFSKEIKDSAGRSKYIFKNKLL 1514

  Fly  1528 TTDMGITEHIEGDETKFAVWTGRSPMLSDCRIVLKATSLETKQIWVKKLREVMQETC--FSGT-- 1588
            |:::|:|||:|||..|||:|.||:|. ||.:.||||:|:|.||.|:|.:|||:||..  ..|.
Zfish  1515 TSELGVTEHVEGDPCKFALWVGRTPS-SDNKTVLKASSIEVKQEWIKNIREVIQERIIHLKGALK 1578

  Fly  1589 -SLTLPKSPAKHSGSSQR-SSRDLDEQLT-ENDHDRCSLASFGSGNTTDSDNKLGNQEATWVVAD 1650
             .:.:||:|||...:|:| :..|.|.|.. .:..|..|:||..|.||.|||...|..|.|.|:.|
Zfish  1579 EPIHIPKTPAKPRNNSKRDAGEDADSQGDGSSQPDTISIASRTSQNTVDSDKLSGGCELTVVLQD 1643

  Fly  1651 YIATSGSNELSVSKGQQVEIVEPPTAGEPDFCLVRLNPQHDDAAVQEGLVPVSVLKP-------- 1707
            :.|:| |:|||:..||.||::|.| :..|.:||||..   :....||||||.|.|..
Zfish  1644 FTASS-SSELSIQTGQTVELLERP-SDRPGWCLVRTT---EKTPPQEGLVPSSALCISHSRSSVE 1703

  Fly  1708 -----PPGSHKHG-SGTAANAASSAGSQKSDMQDQSNRSKADALSSSTKRRGFSGRNWLPLMNRK 1766
                 |.|...:. ||......|.|     .:|.|.:.:...:.|...||.|.:.:.||....|:
Zfish  1704 MDCFFPAGKENYTVSGPEGKTESVA-----TLQPQPSLNSLQSSSPGPKRSGNTLKKWLTSPVRR 1763

  Fly  1767 ---GTD-KPPSSKPLVKKPSEK--NLRTPQKHAEELAEQQNQQPGASPATVLPSSQFPSSTQHPG 1825
               |:: |...||...|:...|  ::..|:...:.|.|:..::.|     .|..|   ||..|.|
Zfish  1764 LSHGSNIKKIPSKQKQKRDGRKSIDMGPPELQDDTLEERVQKEEG-----TLSKS---SSGMHSG 1820

  Fly  1826 GAGAGDYEPDEEVGLELPPPMKPIQEPH--------LIANGPPAFAKDAKESSGNMASPGKMDGN 1882
                |:.||::|....|||||:.|::|.        |:|         :::||.::.|..::
Zfish  1821 ----GEEEPEDESHTPLPPPMEIIKDPSAQEEKSSVLLA---------SRQSSADVPSAAEL--- 1869

  Fly  1883 PLSEIEEIVKTTTEQHESNSRVDGGGGVENASTNGHGRS--HDNNDESHTAVSDKAAALKKRQCV 1945
             :|.||::|||       ...::.|.....:|.|...:|  ...|.|    :..||.||:.|..|
Zfish  1870 -VSAIEKLVKT-------KMTLEPGSYPGFSSVNPAEQSPIPPRNPE----LEQKAKALRGRMFV 1922

  Fly  1946 FAELMSTEEAYVQDLHEIVNGYMTEINNTNSDIPMPEDLKGGKMKLVFNNIKDIYEWHRDFFLRA 2010
            ..||:.||:.||:||..:|.|:|..|....    :|:::| ||.|:||.||..||:||:|||:..
Zfish  1923 VKELIQTEKDYVKDLGIVVEGFMKRIEEKG----VPDNMK-GKDKIVFGNIHQIYDWHKDFFVGE 1982

  Fly  2011 LRNCQKSPADLGPLIKRSATKFALYYTYCSNKPLSEYIVSAHYQYFDSIRQKLGHRLDLSNLIIK 2075
            |..|.:....|..|..:...:..:|..||.|||.||:||:.:..||:.|:|.:..||.:|:.:||
Zfish  1983 LEKCLEDHEKLPELFCKHERRLHMYVVYCQNKPKSEFIVAEYDSYFEGIQQDINSRLSISDFLIK 2047

  Fly  2076 PVQRITKYELLIKEIIKATEGAGLYKEVPMLQEAYQQMKVVVKTVNDMMVVLRSLQDFDGEITAQ 2140
            |:||||||:||:|:::|.:..|||  :...::.|...|..|.|..||||.:.| ||.::|::|:|
Zfish  2048 PIQRITKYQLLLKDVLKYSTKAGL--DCQDIENAVDLMSQVPKLCNDMMNLGR-LQGYEGKLTSQ 2109

  Fly  2141 GSLLMQ----------GPMNCVVDAAQKHRELQVFLFQQIIIFADIEKTKNQYASPIFKYRSHIQ 2195
            |.||.|          |.::       :.:|.:||||:||:||:::  .:...::|.::::..|:
Zfish  2110 GKLLQQETFFVTEQDSGVLS-------RSKERRVFLFEQIVIFSEL--LRKGSSTPGYQFKKSIK 2165

  Fly  2196 LNHMQMKELGD---CRFQIRSTDPKIPEMTIICQAASQENYAGWRDMLNKILQQQNDLIFMLSNP 2257
            ::.:.::|..:   |:| :.|........|:  |||:.:....|...:.::|..|::.:..|.:|
Zfish  2166 VSFLDLEEHVENDPCKF-VLSCRGSAERFTL--QAANTDIKQVWVQHITQLLDLQSNFLSALQSP 2227

  Fly  2258 L 2258
            :
Zfish  2228 I 2228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
trio	NP_651960.2	SEC14	13..152	CDD:214706	76/138 (55%)
		SPEC	314..>468	CDD:238103	82/153 (54%)
		SPEC	563..778	CDD:238103	93/218 (43%)
		SPEC	782..997	CDD:238103	87/229 (38%)
		SPEC	897..1119	CDD:238103	123/237 (52%)
		SPEC	1125..1226	CDD:197544	55/100 (55%)
		RhoGEF	1287..1456	CDD:279015	104/169 (62%)
		PH1_Kalirin_Trio_like	1462..1584	CDD:270060	68/122 (56%)
		PH	1495..1580	CDD:278594	47/85 (55%)
		SH3_Kalirin_1	1643..1707	CDD:212786	29/63 (46%)
		RhoGEF	1945..2122	CDD:279015	70/176 (40%)
		PH2_Kalirin_Trio_p63RhoGEF	2130..2260	CDD:270061	34/142 (24%)
kalrna	XP_017213230.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	229	1.000	Domainoid score	I2403
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1753	1.000	Inparanoid score	I68
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D4513at33208
OrthoFinder	1	1.000	-	-		FOG0002562
OrthoInspector	1	1.000	-	-		otm26277
orthoMCL	1	0.900	-	-		OOG6_103664
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1686
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870