DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip1 and Lipn

DIOPT Version :9

Sequence 1:	NP_001285811.1	Gene:	Lip1 / 43973	FlyBaseID:	FBgn0023496	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	NP_001178884.1	Gene:	Lipn / 499345	RGDID:	1560354	Length:	398	Species:	Rattus norvegicus

Alignment Length:	369	Identity:	126/369 - (34%)
Similarity:	189/369 - (51%)	Gaps:	28/369 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LSVDKLIAKYGYESEVHHVTTEDGYILTMHRI---RKQGA-----PPFLLQHGLVDSSAGFVVMG 122
            ::..::|...||.||.:.|||.|||||.::||   |.|..     |...:||.|...:|.::...
  Rat    34 MNASEIITYNGYPSEEYDVTTADGYILAINRIPHGRGQTGHAGPRPVVYMQHALFADNAYWLENF 98

  Fly   123 PNVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVLKVTG 187
            ||.||.:||||..||||:||:|||.:||.|.||..:|.|||.||:.|:..||||.:||.::..||
  Rat    99 PNGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSVNEEKFWAFSFDEMAKYDLPGIIDFIVNKTG 163

  Fly   188 FPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAISLYFNSLVGSS 252
            ..||::.|||.|.|..|:..|..|....::....||.|.:..|      |..:|...|..|..|.
  Rat   164 QEKLYFIGHSLGTTIGFIAFSTMPELAQRIKMNFALGPVISFK------YPTSIFTSFFLLPRSM 222

  Fly   253 IREMFNGEFRFL----CRMTEET-------ERLCIEAVFGIVGRNWNEFNRKMFPVILGHYPAGV 306
            |:.||..:..||    .:|:..|       ..:|.|.:....|.|....|.....|.:.|.|.|.
  Rat   223 IKLMFGTKGFFLEDKNAKMSYVTVCNKKLLRPMCSEFMSLWAGFNKKNMNMSRLDVYMSHAPTGS 287

  Fly   307 AAKQVKHFIQIIKSGRFAPYSYSSN-KNMQLYRDHLPPRYNLSLVTVPTFVYYSTNDLLCHPKDV 370
            :.:.:.|..|:.:|..|..|.:.|. :||..|....||.|:|:.:.|||.::...:|:|..|:||
  Rat   288 SIQNILHIKQLYQSDEFRAYDWGSEAENMNHYNQSRPPLYDLTAMKVPTAIWAGGHDVLVTPQDV 352

  Fly   371 ESMCDDLGNVTGKYLVPQKEFNHMDFLWAIDVRKMLYRRMLQVL 414
            ..:...:.|:  :|.....|:||.||:|.:|..:.||.:::.::
  Rat   353 ARILPQITNL--RYFKQFPEWNHFDFVWGLDAPQRLYSKIIGLM 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip1	NP_001285811.1	Abhydro_lipase	71..122	CDD:282003	22/58 (38%)
Lip1	NP_001285811.1	Abhydrolase_1	103..399	CDD:278959	105/307 (34%)
Lipn	NP_001178884.1	Abhydro_lipase	37..97	CDD:282003	22/59 (37%)
Lipn	NP_001178884.1	Abhydrolase_1	79..379	CDD:278959	105/307 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335521
Domainoid	1	1.000	229	1.000	Domainoid score	I2382
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2916
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.010