DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip1 and Lipm

DIOPT Version :9

Sequence 1:	NP_001285811.1	Gene:	Lip1 / 43973	FlyBaseID:	FBgn0023496	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_220066.4	Gene:	Lipm / 309528	RGDID:	1304912	Length:	422	Species:	Rattus norvegicus

Alignment Length:	379	Identity:	124/379 - (32%)
Similarity:	207/379 - (54%)	Gaps:	25/379 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DSTLSVDKLIAKYGYESEVHHVTTEDGYILTMHRI-------RKQGA-PPFLLQHGLVDSSAGFV 119
            ::.::|.::|...||.||.:.|.|||||||:::||       :|:|: |..||||||:..::.::
  Rat    44 EAFMNVSEIIKHKGYPSEEYEVATEDGYILSVNRIPRGQTQLKKEGSRPVVLLQHGLLGDASNWI 108

  Fly   120 VMGPNVSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVLK 184
            ...||.||.::|||..:|||:||:|||.:||.|.||..|:.:||.||:.|:..:||||:|:.:|:
  Rat   109 SNLPNNSLGFILADAGFDVWMGNSRGNTWSRKHKTLSIDQDEFWAFSYDEMARFDLPAVINFILQ 173

  Fly   185 VTGFPKLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAISLYFNSLV 249
            .||..|::|.|:|||.|..|:..|..|....|:....||||....|..:. |..:.:.|....:.
  Rat   174 KTGQKKIYYVGYSQGTTMGFIAFSTMPELAHKIKMYFALAPIATVKHAKS-PGTKFLLLPDMMIK 237

  Fly   250 GSSIREMFNGEFRF-------LC-RMTEETERLCIEAVFGIVGRNWNEFNRKMFPVILGHYPAGV 306
            |...|:.|..:.||       || :|.  .:::|...:..:.|.|.|..|.....|.:.|.|||.
  Rat   238 GLFGRQEFLYQTRFFRQLFIYLCGQMI--LDQICSNIILLLGGFNTNNMNMSRANVYVAHTPAGT 300

  Fly   307 AAKQVKHFIQIIKSGRFAPYSY-SSNKNMQLYRDHLPPRYNLSLVTVPTFVYYSTNDLLCHPKDV 370
            :.:.:.|:.|.:.||....:.: |..||.:......|.||.:..:.|||.::....|.|.:|.||
  Rat   301 SVQNILHWSQAVNSGELRAFDWGSETKNREKSNQPTPIRYKVRDMMVPTAMWTGGQDWLSNPDDV 365

  Fly   371 ESMCDDLGNVTGKYLVPQKEFNHMDFLWAIDVRKMLYRRMLQVL---GKVPEGS 421
            :::..::.|:.....:|  |:.|:||:|.:|....:|..::.::   ..:|:|:
  Rat   366 KTLLSEVTNLIYHKNIP--EWAHVDFIWGLDAPHRVYNEIIHLMKQESSLPQGT 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip1	NP_001285811.1	Abhydro_lipase	71..122	CDD:282003	24/58 (41%)
Lip1	NP_001285811.1	Abhydrolase_1	103..399	CDD:278959	101/304 (33%)
Lipm	XP_220066.4	Abhydro_lipase	49..111	CDD:282003	25/61 (41%)
		Abhydrolase_1	92..392	CDD:278959	101/304 (33%)
		Abhydrolase_5	93..>231	CDD:289465	57/138 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335531
Domainoid	1	1.000	229	1.000	Domainoid score	I2382
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2916
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910