DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lip1 and AgaP_AGAP005185

DIOPT Version :9

Sequence 1:	NP_001285811.1	Gene:	Lip1 / 43973	FlyBaseID:	FBgn0023496	Length:	439	Species:	Drosophila melanogaster
Sequence 2:	XP_314084.4	Gene:	AgaP_AGAP005185 / 1274893	VectorBaseID:	AGAP005185	Length:	372	Species:	Anopheles gambiae

Alignment Length:	371	Identity:	163/371 - (43%)
Similarity:	226/371 - (60%)	Gaps:	28/371 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 KLIAKYGYESEVHHVTTEDGYILTMHRIRKQGAP----------PFLLQHGLVDSSAGFVVMGPN 124
            ::|.||||.||:|::.|:||||:.:||:|  .:|          |.||.|||:.|||.:::|||.
Mosquito     8 EIILKYGYNSEIHNIETQDGYIIELHRVR--SSPVYGPANPYKLPVLLMHGLMGSSADWILMGPE 70

  Fly   125 VSLAYLLADHNYDVWLGNARGNRYSRNHTTLDPDESKFWDFSWHEIGMYDLPAMIDHVLKVTGFP 189
            .||.|||:|..:|||||||||||||||||.|.||..:||||::||||:||||.|:||||..||.|
Mosquito    71 ESLPYLLSDQGHDVWLGNARGNRYSRNHTHLSPDGREFWDFTFHEIGLYDLPVMVDHVLAQTGQP 135

  Fly   190 KLHYAGHSQGCTSFFVMCSMRPAYNDKVVSMQALAPAVYAKETEDHPYIRAI------SLYFNSL 248
            :|||.|||||.|.|||:.::||.||.|...|.||||||:....: :|::|.:      :|.|.:.
Mosquito   136 QLHYVGHSQGTTMFFVLNALRPEYNRKFRLMHALAPAVFLTHLQ-NPFLRFLAQHETAALQFVNF 199

  Fly   249 VG----SSIREMFNGEFRFLCRMTEETERLCIEAVFGIVGRNWNEFNRKMFPVILGHYPAGVAAK 309
            .|    ...:|..|...:.|| ....:..||::|:..:.|..::..::..||::|.|.|||.:.|
Mosquito   200 FGIFEVKPYQEDINRLAKALC-PDFYSRALCLDAMHTMTGNKYHHMSQLGFPMLLRHLPAGCSLK 263

  Fly   310 QVKHFIQIIKSGRFAPYSYSSNKNMQLYR-DHLPPRYNLSLVTVPTFVYYSTNDLLCHPKDVESM 373
            ||.||.|.:.||.|.||.|.:.:|.:.|. ..:||.|:|:.||.|..::|...|.|.||.||..:
Mosquito   264 QVAHFGQAVTSGHFRPYDYGAEENRRRYTGSAVPPDYDLTKVTAPVVIFYGLADQLTHPTDVRQL 328

  Fly   374 CDDLGNVTGKYLVPQKEFNHMDFLWAIDVRKMLYRRMLQVLGKVPE 419
            ...|.|:.....:|...|||||||.|.|.:..||.   .::|.|.:
Mosquito   329 AGRLPNLVALNQLPNATFNHMDFLLAGDAKDALYD---SIIGNVEQ 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lip1	NP_001285811.1	Abhydro_lipase	71..122	CDD:282003	26/60 (43%)
Lip1	NP_001285811.1	Abhydrolase_1	103..399	CDD:278959	141/316 (45%)
AgaP_AGAP005185	XP_314084.4	Abhydro_lipase	6..68	CDD:282003	26/61 (43%)
		Abhydrolase	43..>148	CDD:304388	66/104 (63%)
		Abhydrolase_1	50..352	CDD:278959	138/303 (46%)
		Abhydrolase_5	<294..345	CDD:289465	17/50 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2624
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55134
OrthoDB	1	1.010	-	-		D408561at33208
OrthoFinder	1	1.000	-	-		FOG0000083
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11005
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X80
TreeFam	1	0.960	-	-
	8	7.890