DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and TOM71

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_011985.1	Gene:	TOM71 / 856517	SGDID:	S000001159	Length:	639	Species:	Saccharomyces cerevisiae

Alignment Length:	582	Identity:	109/582 - (18%)
Similarity:	205/582 - (35%)	Gaps:	139/582 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AFELQRQVRQNAREYENSVKD----------LYSWEQDIKNKEKELQKSPLSAANKDLPVRSHVQ 61
            |:...:|::|..::.....||          ....|.|:|:     ..|.:|.:||....::..:
Yeast    30 AYVYYQQIKQQQQQQLKGTKDNRRQSEAFAGQNEDEADLKD-----DGSVVSGSNKRKKKKNKRK 89

  Fly    62 TDKSRKESPSSSAASSPTEKQDLP----VDPVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTA 122
            .:...|........|.|..:.|:.    :.| :|:...|..:|:|||.:.....:.:||..|..|
Yeast    90 RNNKAKSGEGFDYPSLPNGEPDIAQLKGLSP-SQRQAYAVQLKNRGNHFFTAKNFNEAIKYYQYA 153

  Fly   123 IAVYPHDPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDC 187
            |.:.|::|:::.|.:.||:.....::.:|....|:.:.....||..||..|||||||..:|:.|.
Yeast   154 IELDPNEPVFYSNISACYISTGDLEKVIEFTTKALEIKPDHSKALLRRASANESLGNFTDAMFDL 218

  Fly   188 TTV--------LAIEP---KNIEAKRSLARINDRLRKIATKSGPNFTPDRPGM----------IE 231
            :.:        .:|||   :|:. |:::..:|:.|.|...: |....|....:          :|
Yeast   219 SVLSLNGDFDGASIEPMLERNLN-KQAMKVLNENLSKDEGR-GSQVLPSNTSLASFFGIFDSHLE 281

  Fly   232 ILPIEKPAYKRSKKAMRSVPVVDVVSPRATIDDSNQLRISDEDIDKIFNSNCGIIEEVKKTNPKP 296
            :..:...:...:..|:.|    |.:....:..|...|..:|     :...:..:...:...|...
Yeast   282 VSSVNTSSNYDTAYALLS----DALQRLYSATDEGYLVAND-----LLTKSTDMYHSLLSANTVD 337

  Fly   297 TPMPDTSGPP---------------KAETIAKTSKEVKPTKQTAVKVAPAVETPKETET-----R 341
            .|:.:.:...               .|:.:.:.|..:.||..:.:.:|..:...:.::.     :
Yeast   338 DPLRENAALALCYTGIFHFLKNNLLDAQVLLQESINLHPTPNSYIFLALTLADKENSQEFFKFFQ 402

  Fly   342 KDTKIVPESDNEAKPSAPKKTAVEVPKVQTQVSPPKTTIERSPEVNTVQTEKIEQASSNNAMSPS 406
            |...:.||.                         |.|...|......:|..|..:.....|.|.:
Yeast   403 KAVDLNPEY-------------------------PPTYYHRGQMYFILQDYKNAKEDFQKAQSLN 442

  Fly   407 PIERFLP------------PAPTSTAQFHVTWKELSGPQKYQYLKSIEVPNLCKILGAGFDSDTF 459
            | |...|            ....|.|.|:.|        |.::....|||..            |
Yeast   443 P-ENVYPYIQLACLLYKQGKFTESEAFFNET--------KLKFPTLPEVPTF------------F 486

  Fly   460 ADLLRTIHDFFVPNKEPNTAAVLLEISKN---------DEFTILAMLMSAEEKKMVSSILNA 512
            |::|....||....|:.:.|..|.|:.:.         .:.||||...|.:..::.....||
Yeast   487 AEILTDRGDFDTAIKQYDIAKRLEEVQEKIHVGIGPLIGKATILARQSSQDPTQLDEEKFNA 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	17/65 (26%)
		TPR repeat	96..124	CDD:276809	9/27 (33%)
		TPR_1	102..129	CDD:278916	9/26 (35%)
		TPR repeat	129..159	CDD:276809	6/29 (21%)
		TPR	130..160	CDD:197478	6/29 (21%)
		TPR_16	136..197	CDD:290168	20/71 (28%)
		TPR repeat	164..192	CDD:276809	13/35 (37%)
		RPAP3_C	415..503	CDD:290588	22/96 (23%)
TOM71	NP_011985.1	3a0801s09	9..636	CDD:273380	109/582 (19%)
		TPR repeat	127..155	CDD:276809	9/27 (33%)
		TPR repeat	160..190	CDD:276809	6/29 (21%)
		TPR repeat	195..218	CDD:276809	12/22 (55%)
		TPR repeat	345..373	CDD:276809	2/27 (7%)
		TPR repeat	378..406	CDD:276809	2/27 (7%)
		TPR repeat	411..441	CDD:276809	6/54 (11%)
		TPR repeat	446..471	CDD:276809	4/24 (17%)
		TPR repeat	480..508	CDD:276809	10/39 (26%)
		TPR repeat	513..559	CDD:276809	7/36 (19%)
		TPR repeat	564..588	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840