DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and TPR5

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_176039.2	Gene:	TPR5 / 842097	AraportID:	AT1G56440	Length:	476	Species:	Arabidopsis thaliana

Alignment Length:	534	Identity:	135/534 - (25%)
Similarity:	226/534 - (42%)	Gaps:	88/534 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RQNAREYENSVKDLYSWEQDIKNKEKELQKSPLSAANKDLPVRSHVQTDKSRKESPSSSAASSPT 79
            |...::::....||..||..:|:|:|::::.|.:::|           ..|....||.|......
plant    10 RDQTQDFQGFFNDLQDWELSLKDKDKKIKQQPANSSN-----------PSSETFRPSGSGKYDFA 63

  Fly    80 EK----QDLPVDPVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDPIYHINRALCY 140
            :|    :||....:.:....::..|::||.:.||.::.:||..||.:||:.| :.:.:.|||:.|
plant    64 KKYRSIRDLSSSLIGESLLDSSSEKEQGNEFFKQKKFNEAIDCYSRSIALSP-NAVTYANRAMAY 127

  Fly   141 LKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLA 205
            ||.:.:.:...||..|:.||...:|||.||..|.:.||...||.:|....|.:||::.|.|:..|
plant   128 LKIKRYREAEVDCTEALNLDDRYIKAYSRRATARKELGMIKEAKEDAEFALRLEPESQELKKQYA 192

  Fly   206 RINDRLRK-IATKSGPNFTPDRPGMIEILPIEKPAYKRSKKAMRSVPVVDVVSPRATIDDSNQLR 269
            .|...|.| |..|:..........:::...::|...| .|..|.|.||..|.
plant   193 DIKSLLEKEIIEKATGAMQSTAQELLKTSGLDKKIQK-PKTEMTSKPVTLVA------------- 243

  Fly   270 ISDEDIDKIFNSNCGIIEEVKKTNPKPTPMPDTSGPPKAETIAKTSKEVKPTKQTAVKVAPAVET 334
                      .:|..|::.|..:|       ::||....|.|....|    :|:.::|: ||:
plant   244 ----------KTNRDIVQPVLGSN-------ESSGKKLIENIQPEEK----SKEGSMKI-PAI-- 284

  Fly   335 PKETETRKDTKIVPES---DNEAKPSAPKKTAVEVPKVQTQVSPPKTTIERSPEVNTVQTEKIEQ 396
               ||.....|:.|.|   :.|||||....|....|  :.|||   ..:|..|.|..:.......
plant   285 ---TEILDSKKVTPGSQSYEKEAKPSDRNGTQPSGP--ENQVS---KQLELKPSVQELAAHAASL 341

  Fly   397 A---SSNNAMSPSPIERFLPPAPTSTAQFHVTWKELSGPQ--KYQYLKSIEVPNLCKILGAGFDS 456
            |   :|.|..:|.           |..:|..:|:..||..  :.|.||.....:|.:|......|
plant   342 AMTEASKNIKTPK-----------SAYEFENSWRSFSGDSALRSQLLKVTTPSSLPQIFKNALTS 395

  Fly   457 DTFADLLRTIHDFFVPNKEPNTAAVLLE-ISKNDEFTILAMLMSAEEKKMVSSILNAI---KNWP 517
            ....|:::.:..||  .::.:.|...:| ::|...|.:|.|.:::.||..:..|...:   |..|
plant   396 PVLVDIIKCVASFF--TEDMDLAVKYIENLTKVPRFNMLVMCLTSTEKNELLKIWEDVFCNKATP 458

  Fly   518 SKNPAVLDNLFKEY 531
            .:...|||.|...|
plant   459 MEYAEVLDKLRSRY 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	22/65 (34%)
		TPR repeat	96..124	CDD:276809	9/27 (33%)
		TPR_1	102..129	CDD:278916	11/26 (42%)
		TPR repeat	129..159	CDD:276809	9/29 (31%)
		TPR	130..160	CDD:197478	9/29 (31%)
		TPR_16	136..197	CDD:290168	24/60 (40%)
		TPR repeat	164..192	CDD:276809	11/27 (41%)
		RPAP3_C	415..503	CDD:290588	20/90 (22%)
TPR5	NP_176039.2	TPR repeat	88..112	CDD:276809	9/23 (39%)
		TPR_1	<91..116	CDD:278916	11/25 (44%)
		TPR_11	116..182	CDD:290150	23/65 (35%)
		TPR repeat	116..146	CDD:276809	9/29 (31%)
		TPR_1	117..150	CDD:278916	11/32 (34%)
		TPR repeat	151..179	CDD:276809	11/27 (41%)
		RPAP3_C	353..441	CDD:290588	21/100 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11613
Inparanoid	1	1.050	127	1.000	Inparanoid score	I1920
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1617844at2759
OrthoFinder	1	1.000	-	-		FOG0006568
OrthoInspector	1	1.000	-	-		oto3511
orthoMCL	1	0.900	-	-		OOG6_103410
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.730