Protein Alignment spag and Rpap3

DIOPT Version :10

• Sequence 1: NP_524664.1
• Gene: spag / 43958
• FlyBaseID: FBgn0015544
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_082279.1
• Gene: Rpap3 / 71919
• MGIID: 1277218
• Length: 660
• Species: Mus musculus
• Alignment Length: 665
• Identity: 164/665 - (24%)
• Similarity: 264/665 - (39%)
• Gaps: 139/665 - (20%)

  Fly     1 MSAQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKEKELQKSPLSAANKDLPVRSHVQTDKS 65
            |::..||.|||.||:.||.|.::.::||..||:|:|.|:.||::....|.....|:|:.....|.
Mouse     1 MTSASKAVELQLQVKHNAEELQDFMRDLEHWEKDMKEKDLELRRQGGVAEENLPPIRNGNFRKKK 65

  Fly    66 RKESPSSSAASSPTE---------------------------KQDLPVDPVAQQYKKAND----- 98
            :|.....|:..:..|                           |:|...|.::|:.:...|
Mouse    66 KKGKAKESSRKTKEENTKNRIKSYDYDAWAKLDVDRILDELDKEDSTHDSLSQESESDEDGIRVD 130

  Fly    99 ------IKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVEDCEAAI 157
                  :|::||.|.|||:|::||..|:..:...|::|:...|||..|.:.:.|.....||..||
Mouse   131 SQKALVLKEKGNKYFKQGKYDEAIECYTKGMDADPYNPVLPTNRASAYFRLKKFAVAESDCNLAI 195

  Fly   158 ALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIATKSGPN- 221
            ||.:...|||.||..|..:|....:|.||...||.:||.|.||...|.:||..|.. ...|||.
Mouse   196 ALSRTYTKAYARRGAARFALQKLEDARKDYEKVLELEPDNFEATNELRKINQALTS-KENSGPGA 259

  Fly   222 --FTPDRPGMIEILP-----------IEKPA----YKRSK---------------------KAMR 248
              ....:|...|..|           .||..    :|..|                     .|.|
Mouse   260 AAAAESKPAAGESKPTGGQQGRQKAIAEKDLGNGFFKEGKYEQAIECYTRGIAADRTNALLPANR 324

  Fly   249 SVPVVDVVSPRATIDDSNQLRISDEDIDKIF------NSNCGIIEEVKKTNPKPTPMPDTSGPPK 307
            ::..:.:........|..|..:.|....|.|      .:..|.|.|.|: :.:...:.:......
Mouse   325 AMAYLKIQRYEEAERDCTQAIVLDGSYSKAFARRGTARTFLGKINEAKQ-DFETVLLLEPGNKQA 388

  Fly   308 AETIAKTSKEV------------KPTKQTAVKVA--PAVETPK--------------ETETRKDT 344
            |..:::..||:            ...:...||..  |...:||              ||....|:
Mouse   389 ATELSRIKKELIEKGHWDDVFLDSTQRHHVVKAVDNPPRGSPKALKKVFIEETGNLIETVDAPDS 453

  Fly   345 K-IVPESD---------NEAKPS------APKKTAVEVPKVQ--TQVSPPKTTIERSPEVNTVQT 391
            . .|||||         .:..||      |..:...:|.|::  :..|.|:..:....:.....:
Mouse   454 SATVPESDRATAAVGTGTKKNPSEGVSLPAGDRPRAKVLKIEAVSDTSAPQAQVGVKQDARQPGS 518

  Fly   392 EKIEQASSNNAMSPSPIERF-LPPAPTSTAQFHVTWKEL-SGPQK-YQYLKSIEVPNLCKILGAG 453
            ||   ||......|..:... |||.|.::.|....:::| |.|:. |||:|:||.....|:....
Mouse   519 EK---ASVRAEQMPGQLAAAGLPPVPANSFQLESDFRQLRSSPEMLYQYVKNIEPSLYPKLFQKN 580

  Fly   454 FDSDTFADLLRTIHDFFVPNKEPNTAAVLLE-ISKNDEFTILAMLMSAEEKKMVSSILNAIKNWP 517
            .|.|.|..:::.:|||::..::|.....:|| :|:...|.:..|.||..|:|:.:.:.|.::...
Mouse   581 LDPDVFNQIIKILHDFYIEREKPALIFEVLERLSQLRRFDMAVMFMSGPERKLTNVLFNHLEKSD 645

  Fly   518 SKNPAVLDNLFKEYG 532
            .|..:| :.|.|.||
Mouse   646 LKEDSV-EELKKRYG 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR repeat	96..124	CDD:276809	12/38 (32%)
		TPR	102..>211	CDD:440225	43/108 (40%)
		TPR repeat	129..159	CDD:276809	10/29 (34%)
		TPR repeat	164..192	CDD:276809	11/27 (41%)
		PLN03209	<296..416	CDD:178748	31/166 (19%)
		RPAP3_C	416..503	CDD:464012	26/89 (29%)
Rpap3	NP_082279.1	TPR 1	8..41		15/32 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..83		8/40 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..128		4/18 (22%)
		TPR	127..>345	CDD:440225	59/218 (27%)
		TPR 2	134..167		12/32 (38%)
		TPR repeat	134..162	CDD:276809	11/27 (41%)
		TPR repeat	167..197	CDD:276809	10/29 (34%)
		TPR 3	169..201		11/31 (35%)
		TPR 4	202..235		14/32 (44%)
		TPR repeat	202..230	CDD:276809	11/27 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..283		6/33 (18%)
		TPR 5	284..317		4/32 (13%)
		TPR repeat	284..312	CDD:276809	4/27 (15%)
		PLN03088	295..>430	CDD:215568	19/135 (14%)
		TPR repeat	317..347	CDD:276809	4/29 (14%)
		TPR 6	319..351		5/31 (16%)
		TPR 7	352..385		6/33 (18%)
		TPR repeat	352..379	CDD:276809	6/27 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	449..485		9/35 (26%)
		RPAP3_C	541..631	CDD:464012	26/89 (29%)