Protein Alignment spag and SPAG1

DIOPT Version :10

• Sequence 1: NP_524664.1
• Gene: spag / 43958
• FlyBaseID: FBgn0015544
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_003105.2
• Gene: SPAG1 / 6674
• HGNCID: 11212
• Length: 926
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 148/638 - (23%)
• Similarity: 241/638 - (37%)
• Gaps: 158/638 - (24%)

  Fly     3 AQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKEKELQKS---------------PLSAANK 52
            |::...|::|.::.:....|...|......|:|:|.|.|..||               |..||..
Human   312 AKKTLSEVERDLKNSEAASETQTKGKRMVIQEIENSEDEEGKSGRKHEDGGGDKKPAEPAGAARA 376

  Fly    53 DLP-VRSHVQ---TDKSR---------------------KESP--SSSAASSPTEKQDLPVDPVA 90
            ..| |..::|   |.|:.                     |.||  :|:||::.......|..  .
Human   377 AQPCVMGNIQKKLTGKAEGGKRPARGAPQRGQTPEAGADKRSPRRASAAAAAGGGATGHPGG--G 439

  Fly    91 QQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDP----------IYHINRALCYLKQES 145
            |..:....:|.:||...:.|::.:|...||.|||:.  :|          |.:.|||.||||:.:
Human   440 QGAENPAGLKSQGNELFRSGQFAEAAGKYSAAIALL--EPAGSEIADDLSILYSNRAACYLKEGN 502

  Fly   146 FDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDR 210
            ...|::||..|:.|....:|...||..|.|:|....:|..|..|||.|:.....|..|:.|::..
Human   503 CSGCIQDCNRALELHPFSMKPLLRRAMAYETLEQYGKAYVDYKTVLQIDCGLQLANDSVNRLSRI 567

  Fly   211 LRKIATKSGPNFTPDRPGMIEILPIEKP--AYKRSKKAM----------RSVPVVDVVSPRATID 263
            |.::   .|||:. ::...|..:|...|  |:..:|:.:          |...:.|..:.:|..:
Human   568 LMEL---DGPNWR-EKLSPIPAVPASVPLQAWHPAKEMISKQAGDSSSHRQQGITDEKTFKALKE 628

  Fly   264 DSNQLRISDEDID----------KIFNSNCGI-------------IEEVKKTNPKPTPMPDTSGP 305
            :.||. ::|::..          ||.|..|.|             .||.|:...:...:.|  |.
Human   629 EGNQC-VNDKNYKDALSKYSECLKINNKECAIYTNRALCYLKLCQFEEAKQDCDQALQLAD--GN 690

  Fly   306 PKA---------------ETIAKTSK----------------EVKPTKQTAVKVAPAVETPKETE 339
            .||               :::...:|                ||........|.||   ..||.|
Human   691 VKAFYRRALAHKGLKNYQKSLIDLNKVILLDPSIIEAKMELEEVTRLLNLKDKTAP---FNKEKE 752

  Fly   340 TRKDTKIVPESDNEAKPSAPKKTAVEVPKVQTQVSPPKTTIERSPEVNTVQTEKIEQASSNNAMS 404
            .|   ||..:..||.| ..|.:.|.|| .:....|.......||||    ..||:..|..|||..
Human   753 RR---KIEIQEVNEGK-EEPGRPAGEV-SMGCLASEKGGKSSRSPE----DPEKLPIAKPNNAYE 808

  Fly   405 PSPIERFLPPAPTSTAQFHVTWKELSGPQKYQYLKSIEVP-NLCKILGAGFDSDTFADLLRTIHD 468
            ...|...|.......|..|              |.:|..| :|...|....:.|||..|::::.:
Human   809 FGQIINALSTRKDKEACAH--------------LLAITAPKDLPMFLSNKLEGDTFLLLIQSLKN 859

  Fly   469 FFVPNKEPNTA-AVLLEISKNDEFTILAMLMSAEEKKMVSSILNAIKNWPSKN 520
            ..: .|:|:.. ..||.:||.:.|.::..|:|..:|:::..:...:.:.|:.:
Human   860 NLI-EKDPSLVYQHLLYLSKAERFKMMLTLISKGQKELIEQLFEDLSDTPNNH 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR repeat	96..124	CDD:276809	8/27 (30%)
		TPR	102..>211	CDD:440225	38/118 (32%)
		TPR repeat	129..159	CDD:276809	13/39 (33%)
		TPR repeat	164..192	CDD:276809	10/27 (37%)
		PLN03209	<296..416	CDD:178748	36/150 (24%)
		RPAP3_C	416..503	CDD:464012	20/88 (23%)
SPAG1	NP_003105.2	3a0801s09	141..>339	CDD:273380	5/26 (19%)
		TPR 1	209..242
		TPR repeat	213..237	CDD:276809
		TPR repeat	242..271	CDD:276809
		TPR 2	244..275
		TPR 3	276..309
		TPR repeat	276..304	CDD:276809
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..452		28/135 (21%)
		TPR 4	445..478		10/34 (29%)
		3a0801s09	<446..>731	CDD:273380	67/293 (23%)
		TPR repeat	448..481	CDD:276809	11/34 (32%)
		TPR repeat	486..516	CDD:276809	12/29 (41%)
		TPR 5	487..520		13/32 (41%)
		TPR repeat	521..549	CDD:276809	10/27 (37%)
		TPR 6	522..554		12/31 (39%)
		TPR 7	623..656		7/33 (21%)
		TPR repeat	624..651	CDD:276809	4/27 (15%)
		TPR repeat	656..686	CDD:276809	5/29 (17%)
		TPR 8	657..690		6/34 (18%)
		TPR repeat	691..718	CDD:276809	3/26 (12%)
		TPR 9	692..724		3/31 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	758..801		14/48 (29%)
		RPAP3_C	803..894	CDD:464012	25/105 (24%)