DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spag and rpap3

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001016680.1	Gene:	rpap3 / 549434	XenbaseID:	XB-GENE-5779008	Length:	657	Species:	Xenopus tropicalis

Alignment Length:	692	Identity:	150/692 - (21%)
Similarity:	264/692 - (38%)	Gaps:	194/692 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSAQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKEKELQKS---------PLSAANKDL-- 54
            ||:..||.|||.|::|||.|.::.::||.:||:|||..:.:|:..         |:  .|||.
Frog     1 MSSPSKAIELQLQMKQNAEELQDFMRDLENWEKDIKQTDAKLRNQTGVDSQILPPI--RNKDFKK 63

  Fly    55 --------PVRSHVQTDKSR------------------------KESPSSSAASSPTEKQDLPVD 87
                    |:....|.|:.:                        |::..||:.|...::..:.||
Frog    64 KKKSKSKPPLEKKSQEDEIKPKKKLLDYEYWDKLDVDRALEDIDKDNNESSSESECGDEDGITVD 128

  Fly    88 PVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVED 152
            .     :||...|::||.|.|.|:|::||..|:..:...|::.:...|||..:.:.:.:.....|
Frog   129 T-----EKALLEKEKGNNYFKSGQYDEAIECYTRGMDADPYNAVLPTNRASAFFRLKKYAVAESD 188

  Fly   153 CEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIATK 217
            |..||||:....|||.||..|..:|.:...|.:|...||.::..|.|||..|.:||..|     :
Frog   189 CNLAIALNHNYAKAYARRGAARLALKDLQGAKEDYEKVLELDVNNFEAKNELRKINKEL-----Q 248

  Fly   218 SGPNFTPDRPGMIEILPIEKPAYK-------RSKKAMRSVPV-------------VDVVSPRATI 262
            |..:...::..:.|.:.:|....|       |.::|:....:             :|..|.....
Frog   249 SSTSDVQEKEAIEEKITVENEEEKKQIEIQQRKQQAIMQKDLGNAYFKEGKYEIAIDCYSQGMEA 313

  Fly   263 DDSNQL------------------------------------------RI-------SDEDIDKI 278
            |.:|.|                                          ||       :.||.:.:
Frog   314 DTTNALLPANRAMAYLKIQKYKEAETDCTLAISLDASYCKAFARRGTARIMLGKQKEAKEDFEMV 378

  Fly   279 FNSNCG----IIEEVKKTNPKPTPMPDTSGPPKAETIAKTSK-----EVKPTKQTAVK-----VA 329
            ...:.|    ::|..|.:....:...||.|..:.:.|....|     ..||.::..::     |.
Frog   379 LKLDPGNKQAVLELEKISRELRSNEKDTKGNKERKLINAVEKLPHQRSTKPLRRMVIEEVGGPVE 443

  Fly   330 PAVETPKETE----------TRKDTKIVPESDNEAKPSAPKKTAVEVPKVQ-------------- 370
            ..:.:..|:.          |:.|.:.:.|..|..  |.|...:.:|||::
Frog   444 SCISSLNESNHGKADSMDLITKADKQDLNEEQNFC--SLPDVPSAKVPKIEEISDTYGSCEPSSG 506

  Fly   371 -----TQVSPPKTTIERSPEVNTVQTEKIEQASSNNAMSPSPIERFLPPAPTSTAQFHVTWKELS 430
                 :|.||||  ||:   |.|..:|.:...              :|..||::.|....::.|.
Frog   507 EEHSVSQPSPPK--IEK---VVTTFSESLNIG--------------IPVVPTNSFQLESDFRRLK 552

  Fly   431 GPQK--YQYLKSIEVPNLCKILGAGFDSDTFADLLRTIHDFFVPNKEPNTA--AVLLEISKNDEF 491
            |...  |:|||.||.....|:.....|.|.|:::|..:.:.:: ||:....  .:|..:|:...|
Frog   553 GNPDLLYRYLKQIEPSFYGKLFQKALDPDLFSEILTILREQYI-NKDSCDLIFEILQRLSELKRF 616

  Fly   492 TILAMLMSAEEKKMVSSILNAIKNWPSKNPAVLDNLFKEYGV 533
            .:..|.:|..::.....:.:.::. ..|....|:.|.|:||:
Frog   617 DMAVMFLSGSDRNNAHILFSHLEQ-SLKGSVSLNALKKKYGL 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	22/65 (34%)
		TPR repeat	96..124	CDD:276809	11/27 (41%)
		TPR_1	102..129	CDD:278916	10/26 (38%)
		TPR repeat	129..159	CDD:276809	7/29 (24%)
		TPR	130..160	CDD:197478	8/29 (28%)
		TPR_16	136..197	CDD:290168	19/60 (32%)
		TPR repeat	164..192	CDD:276809	10/27 (37%)
		RPAP3_C	415..503	CDD:290588	23/91 (25%)
rpap3	NP_001016680.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	39..82		8/44 (18%)
		TPR 2	132..165		12/32 (38%)
		TPR repeat	132..160	CDD:276809	11/27 (41%)
		PLN03088	137..>271	CDD:215568	41/138 (30%)
		TPR repeat	165..195	CDD:276809	7/29 (24%)
		TPR 3	167..199		9/31 (29%)
		TPR 4	200..233		11/32 (34%)
		TPR repeat	200..228	CDD:276809	10/27 (37%)
		TPR 5	284..317		4/32 (13%)
		PLN03088	286..>384	CDD:215568	9/97 (9%)
		TPR repeat	288..312	CDD:276809	2/23 (9%)
		TPR repeat	317..347	CDD:276809	2/29 (7%)
		TPR 6	319..351		1/31 (3%)
		TPR 7	352..385		4/32 (13%)
		TPR repeat	352..380	CDD:276809	4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..517		2/20 (10%)
		TPR 8	503..536		10/51 (20%)
		RPAP3_C	537..626	CDD:372776	23/89 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	49	1.000	Domainoid score	I11675
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11613
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1617844at2759
OrthoFinder	1	1.000	-	-		FOG0006568
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46423
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5292
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.050