Protein Alignment spag and rpap3

DIOPT Version :10

• Sequence 1: NP_524664.1
• Gene: spag / 43958
• FlyBaseID: FBgn0015544
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_001016680.1
• Gene: rpap3 / 549434
• XenbaseID: XB-GENE-5779008
• Length: 657
• Species: Xenopus tropicalis
• Alignment Length: 692
• Identity: 150/692 - (21%)
• Similarity: 264/692 - (38%)
• Gaps: 194/692 - (28%)

  Fly     1 MSAQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNKEKELQKS---------PLSAANKDL-- 54
            ||:..||.|||.|::|||.|.::.::||.:||:|||..:.:|:..         |:  .|||.
 Frog     1 MSSPSKAIELQLQMKQNAEELQDFMRDLENWEKDIKQTDAKLRNQTGVDSQILPPI--RNKDFKK 63

  Fly    55 --------PVRSHVQTDKSR------------------------KESPSSSAASSPTEKQDLPVD 87
                    |:....|.|:.:                        |::..||:.|...::..:.||
 Frog    64 KKKSKSKPPLEKKSQEDEIKPKKKLLDYEYWDKLDVDRALEDIDKDNNESSSESECGDEDGITVD 128

  Fly    88 PVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVED 152
            .     :||...|::||.|.|.|:|::||..|:..:...|::.:...|||..:.:.:.:.....|
 Frog   129 T-----EKALLEKEKGNNYFKSGQYDEAIECYTRGMDADPYNAVLPTNRASAFFRLKKYAVAESD 188

  Fly   153 CEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIATK 217
            |..||||:....|||.||..|..:|.:...|.:|...||.::..|.|||..|.:||..|     :
 Frog   189 CNLAIALNHNYAKAYARRGAARLALKDLQGAKEDYEKVLELDVNNFEAKNELRKINKEL-----Q 248

  Fly   218 SGPNFTPDRPGMIEILPIEKPAYK-------RSKKAMRSVPV-------------VDVVSPRATI 262
            |..:...::..:.|.:.:|....|       |.::|:....:             :|..|.....
 Frog   249 SSTSDVQEKEAIEEKITVENEEEKKQIEIQQRKQQAIMQKDLGNAYFKEGKYEIAIDCYSQGMEA 313

  Fly   263 DDSNQL------------------------------------------RI-------SDEDIDKI 278
            |.:|.|                                          ||       :.||.:.:
 Frog   314 DTTNALLPANRAMAYLKIQKYKEAETDCTLAISLDASYCKAFARRGTARIMLGKQKEAKEDFEMV 378

  Fly   279 FNSNCG----IIEEVKKTNPKPTPMPDTSGPPKAETIAKTSK-----EVKPTKQTAVK-----VA 329
            ...:.|    ::|..|.:....:...||.|..:.:.|....|     ..||.::..::     |.
 Frog   379 LKLDPGNKQAVLELEKISRELRSNEKDTKGNKERKLINAVEKLPHQRSTKPLRRMVIEEVGGPVE 443

  Fly   330 PAVETPKETE----------TRKDTKIVPESDNEAKPSAPKKTAVEVPKVQ-------------- 370
            ..:.:..|:.          |:.|.:.:.|..|..  |.|...:.:|||::
 Frog   444 SCISSLNESNHGKADSMDLITKADKQDLNEEQNFC--SLPDVPSAKVPKIEEISDTYGSCEPSSG 506

  Fly   371 -----TQVSPPKTTIERSPEVNTVQTEKIEQASSNNAMSPSPIERFLPPAPTSTAQFHVTWKELS 430
                 :|.||||  ||:   |.|..:|.:...              :|..||::.|....::.|.
 Frog   507 EEHSVSQPSPPK--IEK---VVTTFSESLNIG--------------IPVVPTNSFQLESDFRRLK 552

  Fly   431 GPQK--YQYLKSIEVPNLCKILGAGFDSDTFADLLRTIHDFFVPNKEPNTA--AVLLEISKNDEF 491
            |...  |:|||.||.....|:.....|.|.|:::|..:.:.:: ||:....  .:|..:|:...|
 Frog   553 GNPDLLYRYLKQIEPSFYGKLFQKALDPDLFSEILTILREQYI-NKDSCDLIFEILQRLSELKRF 616

  Fly   492 TILAMLMSAEEKKMVSSILNAIKNWPSKNPAVLDNLFKEYGV 533
            .:..|.:|..::.....:.:.::. ..|....|:.|.|:||:
 Frog   617 DMAVMFLSGSDRNNAHILFSHLEQ-SLKGSVSLNALKKKYGL 657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR repeat	96..124	CDD:276809	11/27 (41%)
		TPR	102..>211	CDD:440225	37/108 (34%)
		TPR repeat	129..159	CDD:276809	7/29 (24%)
		TPR repeat	164..192	CDD:276809	10/27 (37%)
		PLN03209	<296..416	CDD:178748	29/158 (18%)
		RPAP3_C	416..503	CDD:464012	23/90 (26%)
rpap3	NP_001016680.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..82		8/44 (18%)
		TPR 2	132..165		12/32 (38%)
		TPR repeat	132..160	CDD:276809	11/27 (41%)
		LapB	137..404	CDD:442196	56/271 (21%)
		TPR repeat	165..195	CDD:276809	7/29 (24%)
		TPR 3	167..199		9/31 (29%)
		TPR 4	200..233		11/32 (34%)
		TPR repeat	200..228	CDD:276809	10/27 (37%)
		TPR 5	284..317		4/32 (13%)
		TPR repeat	288..312	CDD:276809	2/23 (9%)
		TPR repeat	317..347	CDD:276809	2/29 (7%)
		TPR 6	319..351		1/31 (3%)
		TPR 7	352..385		4/32 (13%)
		TPR repeat	352..380	CDD:276809	4/27 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..517		2/20 (10%)
		TPR 8	503..536		10/51 (20%)
		RPAP3_C	538..628	CDD:464012	23/90 (26%)