DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and unc-45

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_001303425.1	Gene:	unc-45 / 44910	FlyBaseID:	FBgn0010812	Length:	947	Species:	Drosophila melanogaster

Alignment Length:	483	Identity:	96/483 - (19%)
Similarity:	171/483 - (35%)	Gaps:	129/483 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 AQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAI---AVYPHDPIYHINRALCYLKQESFDQCVE 151
            :::...|...||:||...|...:|:|:..|..||   :.:....:::.|||..|||...::..||
  Fly     7 SEEVSDAGSYKDKGNEAFKASRWEEAVEHYGKAIKAGSKHKELAVFYKNRAAAYLKLGKYENAVE 71

  Fly   152 DCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIAT 216
            ||..::.......||.:||.||.|:|....||.||.|.:...:|.|...:..|.|::
  Fly    72 DCTESLKAAPGDPKALFRRAQAYEALEKFEEAYKDATALFKADPGNKTVQPMLQRLH-------- 128

  Fly   217 KSGPNFTPDRPGMIEILPIEKPAYKRSKKAMRSVPVVDVVSPRATIDD------SNQLRISDED- 274
                            :.:|:.:.:.:|.:.:...::|:....||..|      :|.:.::.|.
  Fly   129 ----------------VVVEERSARNAKTSTKVKQMMDLTFDLATPIDKRRAAANNLVVLAKEQT 177

  Fly   275 -IDKIFNSNCGIIEEVKKTNPKPTPMPDTSGPPKAETIAKTSKE----VKPTKQTAVKVAPAVET 334
             .:.::..:|                     ..|..::.|..|:    |......|.....:||.
  Fly   178 GAELLYKDHC---------------------IAKVASLTKVEKDQDIYVNMVHLVAALCENSVER 221

  Fly   335 PKETETRKDT----KIVPESDNEAKPSA-----PKKTAVEVPKVQTQVSPPKTTIER-SPEVNTV 389
            .|...|....    :::.:.......:|     ....|:...|.:....|.|....| :.|::|:
  Fly   222 TKGVLTELGVPWFMRVLDQKHENCVSTAQFCLQTILNALSGLKNKPDSKPEKELCTRNNREIDTL 286

  Fly   390 QT---EKIEQASSNNAMSPSPIERFLPPAPTSTAQFHVT---WKELSGPQKYQYLKSIEVPNLCK 448
            .|   ..|...:.:.|.....||..       |...|.|   |.|          :.:|:..||:
  Fly   287 LTCLVYSITDRTISGAARDGVIELI-------TRNVHYTALEWAE----------RLVEIRGLCR 334

  Fly   449 ILGAGFDSDTFADLLRTIHDF------FVPNKEPNTAAV-LLEISKN--------------DEF- 491
            :|          |:...:.|:      .:.......|:| |..|.:|              ||:
  Fly   335 LL----------DVCSELEDYKYESAMDITGSSSTIASVCLARIYENMYYDEAKARFTDQIDEYI 389

  Fly   492 --TILAMLMSAEEKKMVSSILNAIKNWP 517
              .:||..|  |.|..|:..:.|:.|.|
  Fly   390 KDKLLAPDM--ESKVRVTVAITALLNGP 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	21/68 (31%)
		TPR repeat	96..124	CDD:276809	11/30 (37%)
		TPR_1	102..129	CDD:278916	8/29 (28%)
		TPR repeat	129..159	CDD:276809	10/29 (34%)
		TPR	130..160	CDD:197478	10/29 (34%)
		TPR_16	136..197	CDD:290168	23/60 (38%)
		TPR repeat	164..192	CDD:276809	13/27 (48%)
		RPAP3_C	415..503	CDD:290588	22/114 (19%)
unc-45	NP_001303425.1	TPR_11	12..81	CDD:290150	21/68 (31%)
		TPR repeat	16..41	CDD:276809	9/24 (38%)
		TPR repeat	46..79	CDD:276809	10/32 (31%)
		TPR_11	50..115	CDD:290150	23/64 (36%)
		TPR	50..83	CDD:197478	10/32 (31%)
		UNC45-central	351..494	CDD:288539	16/67 (24%)
		ARM	668..788	CDD:237987
		armadillo repeat	753..789	CDD:293788
		armadillo repeat	795..826	CDD:293788
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840