DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and Tom70

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_609536.1	Gene:	Tom70 / 34618	FlyBaseID:	FBgn0032397	Length:	589	Species:	Drosophila melanogaster

Alignment Length:	317	Identity:	72/317 - (22%)
Similarity:	119/317 - (37%)	Gaps:	101/317 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 SAANKDLPVRSHVQTDKSRKESPSSSAASSPTEKQDLPVDPVA------------------QQYK 94
            :||:|:|         ...|:.|.:.     .|||.:.:|..|                  ...|
  Fly    38 TAASKEL---------DGEKKRPKAK-----IEKQAISLDGTAPDQELERNQKSAELGEKLSPLK 88

  Fly    95 KANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPHD-----PIYHINRALCYLKQESFDQCVEDCE 154
            :||:.|..||...:.|:|::||..|..||...|.:     .|::.|||..|...:.:....|||.
  Fly    89 EANNYKTEGNNCYRNGKYDEAIKFYDKAIDKCPKEHRTDMAIFYQNRAASYEMLKKWSNVKEDCT 153

  Fly   155 AAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRLRKIATKSG 219
            |::..:....||||||.:|:|:..:..|.|.|.|....:|   :..........||:.|
  Fly   154 ASLEFNPRYAKAYYRRARAHEATKDMNECLDDVTATCILE---MFQNNQTIMFADRVLK------ 209

  Fly   220 PNFTPDRPGMIEILPIEKPAYKRSKKAMRS-VPVVDVVSPRAT-IDDSNQLRISDEDIDKIFNSN 282
                  ..|.::           ::|.||: ||||    |.|. ::...:..|:|.
  Fly   210 ------ETGRLD-----------AEKGMRNRVPVV----PSACFVNTYTRSFIADP--------- 244

  Fly   283 CGIIEEVKKTNPKPTPMPDTSGPPKA--------------ETIAKTSKEVKPTKQTA 325
               ::.:|      .|.|.:..|||.              |.|...::|::.::..|
  Fly   245 ---LQTMK------VPAPKSDAPPKGFLRAHLAFLEEKYEEIIPACTEEIESSEAEA 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	22/70 (31%)
		TPR repeat	96..124	CDD:276809	11/27 (41%)
		TPR_1	102..129	CDD:278916	10/26 (38%)
		TPR repeat	129..159	CDD:276809	9/34 (26%)
		TPR	130..160	CDD:197478	9/29 (31%)
		TPR_16	136..197	CDD:290168	20/60 (33%)
		TPR repeat	164..192	CDD:276809	12/27 (44%)
		RPAP3_C	415..503	CDD:290588
Tom70	NP_609536.1	TPR_11	89..160	CDD:290150	22/70 (31%)
		TPR repeat	90..118	CDD:276809	11/27 (41%)
		TPR repeat	123..158	CDD:276809	9/34 (26%)
		TPR repeat	296..324	CDD:276809
		TPR_11	333..399	CDD:290150
		TPR repeat	334..362	CDD:276809
		TPR repeat	367..397	CDD:276809
		TPR repeat	402..437	CDD:276809
		TPR_16	413..477	CDD:290168
		TPR repeat	443..471	CDD:276809
		TPR repeat	476..507	CDD:276809
		TPR_11	486..539	CDD:290150
		TPR repeat	512..539	CDD:276809
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840