DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and Stip1

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_477354.1	Gene:	Stip1 / 33202	FlyBaseID:	FBgn0024352	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	292	Identity:	74/292 - (25%)
Similarity:	132/292 - (45%)	Gaps:	45/292 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EKAFELQRQVRQN----AREYE---NSVKDLYSWEQDIKNKEKEL--QKSPLSAANKDLPVRSHV 60
            ||..|:.|:.|.:    |:.:.   |:.:.|.:::|.....||.:  .::|            .:
  Fly   233 EKGIEVGRESRADFKLIAKSFARIGNTYRKLENYKQAKVYYEKAMSEHRTP------------EI 285

  Fly    61 QTDKSRKESPSSSAASSPTEKQDLPVDPVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAV 125
            :|..|..|      |....|::...::|     :||.:.|::||.:.|:|:|..|:..|:.||..
  Fly   286 KTSLSEVE------AKIKEEERMAYINP-----EKAEEEKEQGNLFFKKGDYSTAVKHYTEAIKR 339

  Fly   126 YPHDPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTV 190
            .|.||..:.|||.||.|..:||..::||:..|.||:..:|.|.|:.:..:.:....:|.......
  Fly   340 NPDDPKLYSNRAACYTKLAAFDLGLKDCDTCIKLDEKFIKGYIRKGKILQGMQQQSKAQAAYQKA 404

  Fly   191 LAIEPKNIEAKRSLARINDRLRKIATKSGPNFTPDRPGMIEILPIEKPAYKRSKKAMRSVPVVDV 255
            |.::|.|.||.....:.:...::...:...|...| |.:.:||  :.||.:...:.|:|
  Fly   405 LELDPNNAEAIEGYRQCSMNFQRNPQEVLKNAMSD-PEIQQIL--KDPAMRMILEQMQS------ 460

  Fly   256 VSPRATIDDSNQLRISDEDIDKIFNSNCGIIE 287
             .|.|..:......|:|: |.|:..|  |||:
  Fly   461 -DPNAVKEHLQNPAIADK-IMKLLES--GIIQ 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	27/65 (42%)
		TPR repeat	96..124	CDD:276809	10/27 (37%)
		TPR_1	102..129	CDD:278916	10/26 (38%)
		TPR repeat	129..159	CDD:276809	13/29 (45%)
		TPR	130..160	CDD:197478	12/29 (41%)
		TPR_16	136..197	CDD:290168	18/60 (30%)
		TPR repeat	164..192	CDD:276809	4/27 (15%)
		RPAP3_C	415..503	CDD:290588
Stip1	NP_477354.1	TPR_11	6..69	CDD:290150
		TPR repeat	7..32	CDD:276809
		TPR repeat	37..67	CDD:276809
		TPR_11	40..103	CDD:290150
		TPR repeat	72..100	CDD:276809
		TPR_11	175..237	CDD:290150	2/3 (67%)
		TPR repeat	175..203	CDD:276809
		TPR_1	181..208	CDD:278916
		TPR_12	205..278	CDD:290160	11/44 (25%)
		TPR repeat	208..238	CDD:276809	2/4 (50%)
		TPR repeat	250..278	CDD:276809	6/27 (22%)
		TPR_1	250..>276	CDD:278916	5/25 (20%)
		TPR_11	309..375	CDD:290150	27/65 (42%)
		TPR repeat	310..338	CDD:276809	10/27 (37%)
		TPR_1	<317..343	CDD:278916	10/25 (40%)
		TPR repeat	343..373	CDD:276809	13/29 (45%)
		TPR_1	378..411	CDD:278916	6/32 (19%)
		TPR repeat	378..406	CDD:276809	4/27 (15%)
		STI1	439..478	CDD:128966	12/49 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462435
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840