Protein Alignment spag and Ttc12

DIOPT Version :10

• Sequence 1: NP_524664.1
• Gene: spag / 43958
• FlyBaseID: FBgn0015544
• Length: 534
• Species: Drosophila melanogaster
• Sequence 2: NP_766358.1
• Gene: Ttc12 / 235330
• MGIID: 2444588
• Length: 704
• Species: Mus musculus
• Alignment Length: 272
• Identity: 67/272 - (24%)
• Similarity: 122/272 - (44%)
• Gaps: 47/272 - (17%)

  Fly     3 AQEKAFELQRQVRQNAREYENSVKDLYSWEQDIKNK-----EKEL--------QKSPLSAANKDL 54
            |.::..:|||.: :|..|..:.::::.|.:..|:.|     ||:|        :....:..||.:
Mouse     2 ADDQERDLQRFL-ENVDEITSLIQEMNSDDPFIQQKAVLDSEKKLLLMEREQEEDGCRTTLNKTM 65

  Fly    55 PVRSHVQTDKSRKE-SPSSSAASSPTEKQDLPVDPVAQQYKK--------ANDIKDRGNTYVKQG 110
              .|..||.::..| ||.:..||         |:..|::..|        |:.:|::||....:|
Mouse    66 --ISPPQTPENADEMSPDAFLAS---------VEKDAKERAKRRRENRVLADALKEKGNEAFVRG 119

  Fly   111 EYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANE 175
            :||.||..||..:.......:.:.|||..::|...:.:.:.||:.|:..|:.|.|||:...:|:.
Mouse   120 DYETAIFFYSEGLGKLKDMKVLYTNRAQAFIKLGDYQKALVDCDWALKCDENCTKAYFHMGKAHV 184

  Fly   176 SLGNNMEALKDC-TTVLAIEPK---------NIEAKRSLARINDRLRKIATKSGPNFTPDRPGMI 230
            :|.|..:| |:| ..:..|.||         |....|..|.:.::..:.:..||.|.......::
Mouse   185 ALKNYSKA-KECYQKIEEINPKLKAQVKEHLNQVTLREKADLQEKEAQESLDSGKNTAVTTKNLL 248

  Fly   231 EIL--PIEKPAY 240
            |.|  |.:.|.:
Mouse   249 ETLSKPGQTPLF 260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR repeat	96..124	CDD:276809	11/27 (41%)
		TPR	102..>211	CDD:440225	33/118 (28%)
		TPR repeat	129..159	CDD:276809	7/29 (24%)
		TPR repeat	164..192	CDD:276809	9/28 (32%)
		PLN03209	<296..416	CDD:178748
		RPAP3_C	416..503	CDD:464012
Ttc12	NP_766358.1	PLN03088	104..>254	CDD:215568	40/150 (27%)
		TPR 1	105..138		11/32 (34%)
		TPR repeat	105..133	CDD:276809	11/27 (41%)
		TPR repeat	138..168	CDD:276809	7/29 (24%)
		TPR 2	139..172		8/32 (25%)
		TPR 3	173..206		11/33 (33%)
		TPR repeat	173..198	CDD:276809	9/25 (36%)