DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spag and TOMM34

DIOPT Version :9

Sequence 1:	NP_524664.1	Gene:	spag / 43958	FlyBaseID:	FBgn0015544	Length:	534	Species:	Drosophila melanogaster
Sequence 2:	NP_006800.2	Gene:	TOMM34 / 10953	HGNCID:	15746	Length:	309	Species:	Homo sapiens

Alignment Length:	168	Identity:	53/168 - (31%)
Similarity:	90/168 - (53%)	Gaps:	12/168 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PLSAANK--DLPVRSHVQTDKSRKESPSSSAASSPTEKQDLPVDPVAQQYKKANDIKDRGNTYVK 108
            |:||..:  .||..:|.:..||:.:..:::....|:          |...:||..:|:.||..||
Human   151 PVSAQKRWNSLPSENHKEMAKSKSKETTATKNRVPS----------AGDVEKARVLKEEGNELVK 205

  Fly   109 QGEYEKAIVAYSTAIAVYPHDPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQA 173
            :|.::|||..||.::.....:...:.|||||||..:.:.:.|:||..|:.||...|||:|||.||
Human   206 KGNHKKAIEKYSESLLCSNLESATYSNRALCYLVLKQYTEAVKDCTEALKLDGKNVKAFYRRAQA 270

  Fly   174 NESLGNNMEALKDCTTVLAIEPKNIEAKRSLARINDRL 211
            :::|.:...:..|.:.:|.|||:|..|::....:...|
Human   271 HKALKDYKSSFADISNLLQIEPRNGPAQKLRQEVKQNL 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spag	NP_524664.1	TPR_11	95..161	CDD:290150	25/65 (38%)
		TPR repeat	96..124	CDD:276809	12/27 (44%)
		TPR_1	102..129	CDD:278916	10/26 (38%)
		TPR repeat	129..159	CDD:276809	11/29 (38%)
		TPR	130..160	CDD:197478	11/29 (38%)
		TPR_16	136..197	CDD:290168	26/60 (43%)
		TPR repeat	164..192	CDD:276809	10/27 (37%)
		RPAP3_C	415..503	CDD:290588
TOMM34	NP_006800.2	TPR 1	9..42
		TPR repeat	9..37	CDD:276809
		PLN03088	<12..>294	CDD:330826	50/152 (33%)
		TPR repeat	50..80	CDD:276809
		TPR 2	51..84
		TPR repeat	85..113	CDD:276809
		TPR 3	86..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..189		7/37 (19%)
		TPR 4	193..226		12/32 (38%)
		TPR repeat	193..221	CDD:276809	12/27 (44%)
		TPR repeat	226..256	CDD:276809	11/29 (38%)
		TPR 5	227..260		13/32 (41%)
		TPR repeat	261..289	CDD:276809	10/27 (37%)
		TPR 6	262..294		13/31 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40300
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910