DRSC/TRiP Functional Genomics Resources

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Protein Alignment spag and STUB1

DIOPT Version :10

Sequence 1:NP_524664.1 Gene:spag / 43958 FlyBaseID:FBgn0015544 Length:534 Species:Drosophila melanogaster
Sequence 2:NP_005852.2 Gene:STUB1 / 10273 HGNCID:11427 Length:303 Species:Homo sapiens


Alignment Length:169 Identity:48/169 - (28%)
Similarity:73/169 - (43%) Gaps:31/169 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 KSRKESPSSSAASSPTEKQDLPVDPVAQQYKKANDIKDRGNTYVKQGEYEKAIVAYSTAIAVYPH 128
            |..||..:...|...:.::    .|.||      ::|::||......:|.:|...|..||...|.
Human     4 KEEKEGGARLGAGGGSPEK----SPSAQ------ELKEQGNRLFVGRKYPEAAACYGRAITRNPL 58

  Fly   129 DPIYHINRALCYLKQESFDQCVEDCEAAIALDKLCVKAYYRRMQANESLGNNMEALKDCTTVLAI 193
            ..:|:.||||||||.:..:|.:.||..|:.||...|||::...|....:.:..||:         
Human    59 VAVYYTNRALCYLKMQQHEQALADCRRALELDGQSVKAHFFLGQCQLEMESYDEAI--------- 114

  Fly   194 EPKNIEAKRSLARINDRLRKIATKSGPNFTPDRPGMIEI 232
              .|::...|||: ..||         ||..|.|..:.|
Human   115 --ANLQRAYSLAK-EQRL---------NFGDDIPSALRI 141

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spagNP_524664.1 TPR repeat 96..124 CDD:276809 7/27 (26%)
TPR 102..>211 CDD:440225 33/108 (31%)
TPR repeat 129..159 CDD:276809 13/29 (45%)
TPR repeat 164..192 CDD:276809 6/27 (22%)
PLN03209 <296..416 CDD:178748
RPAP3_C 416..503 CDD:464012
STUB1NP_005852.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30 7/35 (20%)
Spy 25..>124 CDD:443119 34/115 (30%)
TPR 1 26..59 11/38 (29%)
TPR repeat 26..54 CDD:276809 9/33 (27%)
TPR repeat 59..89 CDD:276809 13/29 (45%)
TPR 2 60..93 15/32 (47%)
TPR repeat 94..122 CDD:276809 7/38 (18%)
TPR 3 95..127 9/43 (21%)
Required for interaction with MAPK7. /evidence=ECO:0000269|PubMed:20724525 101..200 14/62 (23%)
CHIP_TPR_N 142..225 CDD:436460 48/169 (28%)
Required for interaction with and ubiquitination of MYOCD. /evidence=ECO:0000250|UniProtKB:A6HD62 142..196 48/169 (28%)
Required for ubiquitination of FOXO1. /evidence=ECO:0000269|PubMed:19483080 143..303
Required for interaction with FOXO1. /evidence=ECO:0000269|PubMed:19483080 143..197
RING-Ubox_CHIP 227..297 CDD:438316
Blue background indicates that the domain is not in the aligned region.

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