DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cds and cds2

DIOPT Version :9

Sequence 1:	NP_001286976.1	Gene:	Cds / 43950	FlyBaseID:	FBgn0010350	Length:	447	Species:	Drosophila melanogaster
Sequence 2:	NP_957480.1	Gene:	cds2 / 394161	ZFINID:	ZDB-GENE-030717-4	Length:	444	Species:	Danio rerio

Alignment Length:	453	Identity:	269/453 - (59%)
Similarity:	330/453 - (72%)	Gaps:	33/453 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAEVRRRKGEDEPL-----EDTAISGSDAANK-RNSAADSSDHVDSEEEKIPEEKFVDELAKNLP 59
            |||:|:|...|:.|     ||   .||:...| |:.|:||        |..||          :|
Zfish     1 MAELRQRGATDKELKHQHSED---KGSETEGKERDGASDS--------ETKPE----------VP 44

  Fly    60 QGTDKTPEILDSALKDLPDRWKNWVIRGIFTWIMICGFALIIYGGPLALMITTLLVQVKCFQEII 124
            ...|.|||:|:.||..|..|||||.:|||.|..||..|..|||.||:.||:..|.||:|||||||
Zfish    45 VSADDTPEVLNKALSGLSSRWKNWWVRGILTLAMISFFFFIIYLGPMVLMMIVLCVQIKCFQEII 109

  Fly   125 SIGYQVYRIHGLPWFRSLSWYFLLTSNYFFYGENLVDYFGVVINRVEYLKFLVTYHRFLSFALYI 189
            :|||.||..:.|||||:|||||||..|||||||.:.|||..::.|.|.|:.|..||||:|||||:
Zfish   110 TIGYSVYHSYDLPWFRTLSWYFLLCVNYFFYGETVTDYFFTLVQREEPLRILSKYHRFISFALYL 174

  Fly   190 IGFVWFVLSLVKKYYIKQFSLFAWTHVSLLIVVTQSYLIIQNIFEGLIWFIVPVSMIVCNDVMAY 254
            .||..||||||||:|..||.:|.||||:||||||||:|||.|:|||:||||||:|.::|||:|||
Zfish   175 TGFCMFVLSLVKKHYRLQFYMFGWTHVTLLIVVTQSHLIIHNLFEGMIWFIVPISCVICNDIMAY 239

  Fly   255 VFGFFFGRTPLIKLSPKKTWEGFIGGGFATVLFGILFSYVLCNYQYFICPIQYSEEQGRMTMSCV 319
            :|||||||||||||||||||||||||.|:|::||||.|||:..|.||:||::::.:..|.|:.|.
Zfish   240 MFGFFFGRTPLIKLSPKKTWEGFIGGFFSTIVFGILLSYVMAGYSYFVCPVEFNNDSNRFTVDCQ 304

  Fly   320 PSYLFTPQEYSL-----KLFGIGKTLNLYPFIWHSISLSLFSSIIGPFGGFFASGFKRAFKIKDF 379
            ||.||..|:|||     .:.| ..|:.||||..|||:||.|:||:||||||||||||||||||||
Zfish   305 PSELFQLQDYSLPSVLQSITG-WTTVKLYPFQIHSIALSSFASIMGPFGGFFASGFKRAFKIKDF 368

  Fly   380 GDMIPGHGGIMDRFDCQFLMATFVNVYISSFIRTPSPAKLLTQIYNLKPDQQYQIYQSLKDNL 442
            .:.||||||||||||||:||||||||||:||||.|:|:|::.|:..|:||||..|:.|||.:|
Zfish   369 ANTIPGHGGIMDRFDCQYLMATFVNVYIASFIRGPNPSKVIQQLLALRPDQQLHIFNSLKAHL 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cds	NP_001286976.1	CTP_transf_1	120..438	CDD:304393	213/322 (66%)
cds2	NP_957480.1	CTP_transf_1	105..436	CDD:304393	217/328 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590489
Domainoid	1	1.000	476	1.000	Domainoid score	I408
eggNOG	1	0.900	-	-		E1_COG0575
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1128
OMA	1	1.010	-	-		QHG54574
OrthoDB	1	1.010	-	-		D1072976at2759
OrthoFinder	1	1.000	-	-		FOG0001281
OrthoInspector	1	1.000	-	-		otm25208
orthoMCL	1	0.900	-	-		OOG6_101561
Panther	1	1.100	-	-	O	PTHR13773
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2065
SonicParanoid	1	1.000	-	-		X636
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.800