DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and IMH1

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_013412.1	Gene:	IMH1 / 851018	SGDID:	S000004300	Length:	911	Species:	Saccharomyces cerevisiae

Alignment Length:	901	Identity:	159/901 - (17%)
Similarity:	343/901 - (38%)	Gaps:	207/901 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  1801 LKCDKCQAERHHLVDN-GCKICDNCTLLLLDYMELVGNKLRRGMHNMDLTGIPAPYRKLSEYESA 1864
            ||.:|.:|....|.:| .....|:....|..:.:.:.||  ..:.|.::..:.....::.|..|:
Yeast    70 LKSEKLEAVEKILAENTPISNIDDAVDTLPAFFQDLNNK--NNLLNDEIKRLTKQNSEIPESASS 132

  Fly  1865 YEKWNGRHWDFSQTKRRLQDY-DSADILKLEAHAENLKFQS------------RKAVATI----- 1911
             |....:..:|   .::.|:| :..|.||.:..|.|::..:            |:.:..:
Yeast   133 -ETLKDKEEEF---LKKEQNYKNDIDDLKKKMEALNIELDTVQKEKNDTVSGLREKIVALENILK 193

  Fly  1912 -------GKREFAIKSMREDAVTQQHSVGLLRSEILQTLSDLHGYG-----KSAHYLSLPTALKQ 1964
                   .|.|.:|..::|:...:.||:...|.:|.:...:|....     ||:....|...||:
Yeast   194 EEREAKKQKEEVSISELKEELAIKNHSLEDSRMKITELEQNLSSKSTIMEEKSSELAELNITLKE 258

  Fly  1965 ARFYLQAI-----------------------------------------------------REHD 1976
            ....|..:                                                     .|:|
Yeast   259 KERKLSELEKKMKELPKAISHQNVGNNNRRKKNRNKGKKNKGGITTGDISEEETVDNSINTEEYD 323

  Fly  1977 QMVQGIRST----NDCA-WKHFY--AMGNASDASFDESGRLEMLWRDLNQTNHRVVDMRLQVDRV 2034
            ::.:.::..    .||. ||..|  ......||...|:.:||...::|...|..::|.:   ..:
Yeast   324 KLKENLQELQEKYKDCEDWKQKYEDIEAELKDAKELENSQLEKSAKELETLNTELIDTK---KSL 385

  Fly  2035 QEVENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGYLEQGEGLLRLTVQRQIMLNGHL 2099
            :|..:|.|:|.:.:|.:...:.::..|:.|.:.:           |.|.:..:.::...:.:.:.
Yeast   386 KEKNSELEEVRDMLRTVGNELVDAKDEIKESSSK-----------QNEEVKTVKLELDDLRHKNA 439

  Fly  2100 NQLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNEYARKFQPTRNGARIAML--- 2161
            ..::.|. ..||.|..|.|        .|.|..:|..:|.....:     :.|.:..::|.|
Yeast   440 TMIEAYE-AKNTELRSKIE--------LLSKKVEHLKNLCTEKEK-----EQTTSQNKVAKLNEE 490

  Fly  2162 ---ASSAHSNITEAINDARLASILAKERV--YEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEAL 2221
               .:...||||:.:...| .|...||:.  |..::....|:...:.|::      ::||:::..
Yeast   491 ISQLTYEKSNITKELTSLR-TSYKQKEKTVSYLEEQVKQFSEQKDVAEKS------TEQLRKDHA 548

  Fly  2222 KQMHKSNVLK---DKLHRQEQQVEGIKSTIYDSGLRTN-NISGQLQGLSD-----GSARRQAKDS 2277
            |..::.::||   :.||....:    .|..|:..|:.| .:|.:|..|.:     .:.:..:.:.
Yeast   549 KISNRLDLLKKENETLHNDIAK----NSNSYEEYLKENGKLSERLNILQEKYNTLQNVKSNSNEH 609

  Fly  2278 LEMADRTGEQMRAELQKAKDMQKSIQNMRNSFSNLEPDWEIKLGMAQENISLTQTN-----LRLA 2337
            ::...|..|::..:|:::.....|:::..|.::|:..|...:....:..:|.:||:     ..|.
Yeast   610 IDSIKRQCEELNVKLKESTKKILSLEDELNEYANIVQDKTREANTLRRLVSDSQTDDSSKQKELE 674

  Fly  2338 NVSLSYLEQQAEKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKC-------- 2394
            | .|:||..:..|.:...::..:..|.:||:.:..:.:.:....|:.:..|.|..:.
Yeast   675 N-KLAYLTDEKNKLEAELDLQTSRKATELQEWKHTVTELKSEIHALKLREEGLKSEVDALKHVNN 738

  Fly  2395 -IRSYLPASYGLS------TSN-KIRMSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWN 2451
             |:....|:...|      ||| |:.:|.|...:.|    :..|:.:..::..||.|:..||:.|
Yeast   739 DIKRKTQATSDDSDQLEQITSNLKLSLSKADEKNFE----LQSANEKLLNLNNELNKKFDRLLKN 799

  Fly  2452 LGGTTATVTHPMVVHTRDPKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITGSTDTE 2516
            ....::.:.     ..::.:|.|....|  :|:.::|:|....:::       :|...:..|..|
Yeast   800 YRSLSSQLN-----ALKERQYSDKSGRV--SRSGSIGTLANANIDS-------SPANNSNPTKLE 850

  Fly  2517 HTRFYQS------RSDRIS------LGGFASKDL--QFTPGLNVVVHQVEVDNKPL 2558
            ..|...|      ::::|:      ||....|:.  |..|.:::::.....|.|.|
Yeast   851 KIRSSSSLELDSEKNEKIAYIKNVLLGFLEHKEQRNQLLPVISMLLQLDSTDEKRL 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484
		EGF_Lam	401..450	CDD:238012
		TNFRSF	<407..507	CDD:304602
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:278482
		Laminin_B	660..798	CDD:278481
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012	6/18 (33%)
		CrfC	<1933..2267	CDD:223771	71/410 (17%)
		Laminin_II	2277..2400	CDD:283628	23/136 (17%)
		LamG	2399..>2492	CDD:304605	22/99 (22%)
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
IMH1	NP_013412.1	Smc	42..746	CDD:224117	123/721 (17%)
IMH1	NP_013412.1	GRIP	868..906	CDD:396170	8/37 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2160
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030