Protein Alignment wb and NTNG2

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_011517396.1
• Gene: NTNG2 / 84628
• HGNCID: 14288
• Length: 636
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 129/591 - (21%)
• Similarity: 201/591 - (34%)
• Gaps: 202/591 - (34%)

  Fly   171 TCGQNGAEEYCKQVGAKPC-GICNAHSSDRAKQRSIQSLISSGSGSGSGSGF---EEG---WWQS 228
            ||| :..|.:|.......| ..|:|.:.|.|....:.              |   |||   :|||
Human    60 TCG-DPPERFCSHENPYLCSNECDASNPDLAHPPRLM--------------FDKEEEGLATYWQS 109

  Fly   229 PTLQGGRQFEYVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADC 292
            .|...........|.|...:|.::....:.:....||...:|||||| |..::|:|::.   .||
Human   110 ITWSRYPSPLEANITLSWNKTVELTDDVVMTFEYGRPTVMVLEKSLDNGRTWQPYQFYA---EDC 171

  Fly   293 QRRWNLSGQNGKYVFQNDT-EIICSTQFSK---------------------PGP-LENGVLHASL 334
            ...:.:|.:..:.:..:.. .::|:.::|:                     .|| |.|
Human   172 MEAFGMSARRARDMSSSSAHRVLCTEEYSRWAGSKKEKHVRFEVRDRFAIFAGPDLRN------- 229

  Fly   335 LKNRPGATDQSPELMKFITTRYIRIRL--QGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVS 397
            :.|.....:.:..|.:|.|...:|:||  ..:..|         .:...:|.|: ||::|.::|.
Human   230 MDNLYTRLESAKGLKEFFTLTDLRMRLLRPALGGT---------YVQRENLYKY-FYAISNIEVI 284

  Fly   398 ARLDCNGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGG--------------- 447
            .|..||.|||..  |..:..:||.|:|||.|..|.:|...|:.|.::.|.
Human   285 GRCKCNLHANLC--SMREGSLQCECEHNTTGPDCGKCKKNFRTRSWRAGSYLPLPHGSPNACATA 347

  Fly   448 ----------------------------------------------------------------- 447
                                                                             
Human   348 GSFGSISRSQKDPDPKGPVATAATTAMTGAPTTPVPSTSTAWAPMAPSTPQPTEWTRPSTAAPLS 412

  Fly   448 ------------------------------------------ECEICQCYGHAESCTYDPFLDKG 470
                                                      |.:.|:||||:..|:|..||:..
Human   413 SRWSQVASRAEAVGTPAAAPAPAKGYKLFQLKPKSPQVMPIEEFQDCECYGHSNRCSYIDFLNVV 477

  Fly   471 ICQSCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCNPARSTGGCQSDGGSCNCLEGFQGK 533
            .|.||.:||.|..|:.|.:|:||...|.|.|.  |:.|:||...|.....::.|.|.|.||..|.
Human   478 TCVSCKHNTRGQHCQHCRLGYYRNGSAELDDENVCIECNCNQIGSVHDRCNETGFCECREGAAGP 542

  Fly   534 NCEECAP-GYYGDDCKRCECDERGSL-GSTGSC--SGVCQCKLNVEGSTCSE--CAPGYFD--LS 590
            .|::|.| .|:...|....||:...| .:.|:|  :..|.|.....|..|.:  |.|...|  |.
Human   543 KCDDCLPTHYWRQGCYPNVCDDDQLLCQNGGTCLQNQRCACPRGYTGVRCEQPRCDPADDDGGLD 607

  Fly   591 AENAEG 596
            .:.|.|
Human   608 CDRAPG 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653	55/259 (21%)
		EGF_Lam	401..450	CDD:238012	19/170 (11%)
		EGF_Lam	505..552	CDD:238012	15/47 (32%)
		Laminin_EGF	550..597	CDD:395007	15/54 (28%)
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008
		Laminin_II	2279..2400	CDD:368703
		LamG	2399..>2492	CDD:473984
		LamG	2586..2753	CDD:238058
		Laminin_G_2	2804..2944	CDD:460494
		LamG	3018..3167	CDD:238058
		LamG	3192..3347	CDD:238058
NTNG2	XP_011517396.1	Laminin_N	60..285	CDD:459653	55/259 (21%)
		EGF_Lam	286..332	CDD:238012	18/47 (38%)
		EGF_Lam	459..507	CDD:238012	21/47 (45%)
		Laminin_EGF	515..562	CDD:395007	15/46 (33%)