DRSC/TRiP Functional Genomics Resources

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Protein Alignment wb and Ntng1

DIOPT Version :9

Sequence 1:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster
Sequence 2:XP_006502418.1 Gene:Ntng1 / 80883 MGIID:1934028 Length:581 Species:Mus musculus


Alignment Length:524 Identity:139/524 - (26%)
Similarity:205/524 - (39%) Gaps:137/524 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   171 TCGQNGAEEYCKQVGAKPC-GICNAHSSDRAKQRSIQSLISSGSGSGSGSGFE-EG-----WWQS 228
            ||| :..|.:|.......| ..|:|.:.:.|....:.              |: ||     :|||
Mouse    71 TCG-DPPESFCAMGNPYMCNNECDASTPELAHPPELM--------------FDFEGRHPSTFWQS 120

  Fly   229 PTLQGGRQFEY-----VTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGL 287
            .|.:     ||     |.|.|...:|.::....:.:..|.||...||||||| |..::|:||:. 
Mouse   121 ATWK-----EYPKPLQVNITLSWSKTIELTDNIVITFESGRPDQMILEKSLDYGRTWQPYQYYA- 179

  Fly   288 SDADCQRRWNLSGQNGKYVFQNDT-EIICSTQFSKPGPLENGVLHASL-----------LKNRP- 339
              .||...:::..::.|.:.|:.. ||||:.::|......:.::|..:           |:|.. 
Mouse   180 --TDCLHAFHMDPKSVKDLSQHTVLEIICTEEYSTGYSTNSKIIHFEIKDRFAFFAGPRLRNMAS 242

  Fly   340 --GATDQSPELMKFITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDC 402
              |..|.:.:|..|.|...:||||  :.....     :..:|...|.:: ||::|.:||..|..|
Mouse   243 LYGQLDTTKKLRDFFTVTDLRIRL--LRPAVG-----EIFVDELHLARY-FYAISDIKVRGRCKC 299

  Fly   403 NGHANRSHESPDDPLMQCICQHNTCGAQCEQCCPLFQDRPYQMGGECEI---------------- 451
            |.||...  ..|:..:.|.|:|||.|..|.:|...:|.||:..|....|                
Mouse   300 NLHATSC--LYDNSKLTCECEHNTTGPDCGKCKKNYQGRPWSPGSYLPIPKGTANTCIPSISSIG 362

  Fly   452 -------------------------------------------CQCYGHAESCTYDPFLDKGICQ 473
                                                       |:|:||:..|:|...|:..||.
Mouse   363 TPPKFNRIWPNISSLEVSNPKQVAPKLALSTVSSVQVANHKRDCECFGHSNRCSYIDLLNTVICV 427

  Fly   474 SCSNNTAGIECEFCEMGFYRELDAPLTDP--CLPCSCNPARSTGGCQSDGGSCNCLEGFQGKNCE 536
            ||.:||.|..||.|.:|::|...|.|.|.  |:.|.|||..|.....:..|.|.|..|..|..|:
Mouse   428 SCKHNTRGQHCELCRLGYFRNASAQLDDENVCIECYCNPLGSIHDRCNGSGFCECKTGTTGPKCD 492

  Fly   537 ECAPG---YYGDDCKRCECD-ERGSLGSTGSCSG--VCQCKLNVEGSTCSECAPGYFDLSAENAE 595
            ||.||   |||  |:...|| |.....:.|:|..  .|.|.....|..|.:       |..|.|.
Mouse   493 ECLPGNSWYYG--CQPNVCDNELLHCQNGGTCQNNVRCACPDAYTGILCEK-------LRCEEAG 548

  Fly   596 GCTS 599
            .|.|
Mouse   549 SCGS 552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wbNP_723870.1 Laminin_N 164..396 CDD:278484 62/252 (25%)
EGF_Lam 401..450 CDD:238012 17/48 (35%)
TNFRSF <407..507 CDD:304602 37/160 (23%)
EGF_Lam 505..552 CDD:238012 19/49 (39%)
Laminin_EGF 550..597 CDD:278482 12/49 (24%)
Laminin_B 660..798 CDD:278481
EGF_Lam 851..900 CDD:238012
Laminin_EGF <943..971 CDD:278482
VSP 953..1414 CDD:146106
Laminin_EGF 974..1018 CDD:278482
EGF_Lam 1017..1065 CDD:238012
Laminin_EGF 1065..>1105 CDD:278482
EGF_Lam 1150..1197 CDD:238012
Laminin_EGF 1199..1247 CDD:278482
EGF_Lam 1247..1292 CDD:238012
Laminin_EGF 1294..1342 CDD:278482
Laminin_EGF 1340..1392 CDD:278482
Laminin_B 1486..1611 CDD:278481
EGF_Lam 1669..1716 CDD:238012
Laminin_EGF 1718..1767 CDD:278482
EGF_Lam 1772..1819 CDD:238012
CrfC <1933..2267 CDD:223771
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Ntng1XP_006502418.1 Laminin_N 71..295 CDD:365840 64/254 (25%)
EGF_Lam 296..342 CDD:238012 17/47 (36%)
EGF_Lam 406..454 CDD:238012 20/47 (43%)
EGF_Lam 462..509 CDD:214543 19/48 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 57 1.000 Domainoid score I10862
eggNOG 1 0.900 - - E1_KOG1836
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.900

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