Protein Alignment wb and cntnap5l

DIOPT Version :10

• Sequence 1: NP_723870.1
• Gene: wb / 43946
• FlyBaseID: FBgn0261563
• Length: 3375
• Species: Drosophila melanogaster
• Sequence 2: XP_001338473.5
• Gene: cntnap5l / 798019
• ZFINID: ZDB-GENE-140106-102
• Length: 1310
• Species: Danio rerio
• Alignment Length: 1383
• Identity: 288/1383 - (20%)
• Similarity: 459/1383 - (33%)
• Gaps: 440/1383 - (31%)

  Fly  2178 LASILAKERVYEAQRTLYPSDGSSMIERAKHSLHRSKQLQQEALKQMHKSNVLKDKLHRQ----- 2237
            |.|:|:....|..:..|.....||....:|:|..||....               ||:|:
Zfish    18 LTSVLSASNYYCEEPLLTSLPTSSFRNSSKYSDRRSPHYA---------------KLNRRDGGGG 67

  Fly  2238 -----EQQVEGIKSTIYDSGLRTNNISGQLQ-GLSDGSARRQAKDSLEMAD--RTGEQMRAE--- 2291
                 |.|...::..:.|. |:..:|:.|.: |.||..||.|    |..:|  ||....|.|
Zfish    68 WSPSGEDQQPWLQLDLRDR-LKVTSIATQGRWGSSDWVARYQ----LHYSDSGRTWRPYRQEDVI 127

  Fly  2292 --LQKAKDMQKSIQ-----NMRNSFSNLEP-DWEIKLGMAQENISLTQTNLRLANVSLSYLEQQA 2348
              .....|....:|     ::|..:..|.| :...:.||          .|||.....:|....|
Zfish   128 WTFTGNSDTDTVVQHKLPHSIRTRYMRLLPIEGSPRGGM----------GLRLEVYGCTYKSDVA 182

  Fly  2349 EKEQQVFEVWNNSMAQQLQQLRDQIAKARHAAEAIDVSLESLGPKCIRSYLPASYGLSTSNKIR- 2412
            :.:.                                           ||.|...:...:::.::
Zfish   183 DFDG-------------------------------------------RSALLYRFNQKSTSTVKD 204

  Fly  2413 -MSFALSNHLESSPLIHLASSEGRHITLELYKRRVRLVWNL-------GGTTATVTHPMVVHTRD 2469
             :|....:|.....|:|.....|..:||||.:.|:.|..||       ||.:::|   |:....|
Zfish   205 VISLRFRSHQAEGVLVHGEGQRGDFLTLELQRGRLILHLNLDDAKPQSGGRSSSV---MLGSLLD 266

  Fly  2470 PKYDDAWYHVEANRTLNLGSLVVRRMNNYGELTPPNPVIITGSTDTEHTRFYQSRSD-------- 2526
               |..|:.|:           :.|.|.:...|      :.|     ||:.::|...
Zfish   267 ---DHHWHSVQ-----------IERFNKHVNFT------VDG-----HTQHFRSLGQEDTLEIDY 306

  Fly  2527 RISLGGF----------------ASKDLQFTPGLNVVVHQVEVDNKP----LGLWNFVTSEGSCG 2571
            .:|.||.                ..::|.:. |:||:  .:....||    :|...|     ||
Zfish   307 ELSFGGIPLPGKPGTFLHENFHGCIENLNYN-GVNVI--DMAKRRKPQIYTVGNVTF-----SC- 362

  Fly  2572 GSMVGAKESSASSTARHFNGLGYAQLMKTRPRPTRKNLFSVQMTFRTLDENALLFLA--VDDKNN 2634
                    |.:||.|..|  |.........|.....:..||::.|||.::..|||..  ..|.:.
Zfish   363 --------SESSSVAVTF--LSSTGSFLALPADYSMDSLSVRLQFRTWNQEGLLFSVPLSHDPDP 417

  Fly  2635 RSVSVTLSRGRIMFRIDYGDESKLEINTTKKYNVGQWIKIEAAREFSAKRSTENGMLRVNNDRP- 2698
            .::.:.||:.|::..:..|.::..::.:.:..|.|||..|      |.:...|...|.|||.:|
Zfish   418 INLLLRLSQARLLLLLSGGPQNSAQVFSGQNLNDGQWHSI------SVEVKGEKVSLTVNNQKPA 476

  Fly  2699 ---ISGAPTLPVNIHLLPDLSKTVYYLGGVPPGFTSGTSKAPGADNPFLGCMKDVQVNGETYDPL 2760
               |:|....|         .:|..|:||.|...::...:.||  ..:.||.:.:.:|....:.|
Zfish   477 TMEITGRSQTP---------QRTTIYIGGCPLFQSNFNCENPG--RGYQGCFRLLLINNHPVNFL 530

  Fly  2761 E------------SSSYYGVEPSC-KNMITKAG------------FSGNGY---------LELPS 2791
            :            |.....::..| .|:....|            .||.||         .|...
Zfish   531 QIQQENMGNFSQISFDVCNIQDRCLPNLCEHGGQCIQSWDQFDCNCSGTGYTGATCHNSIYERSC 595

  Fly  2792 QSLRKRSNTALVFRTLQPDCLLLLAAYPPEILGDYDAKDIKGNFSISLVDGQLHVWVNSGRSF-- 2854
            ::.||..:.:.||..                  |.|...:..:..::....:..||...|...
Zfish   596 EAFRKTGSQSSVFTI------------------DLDGSGLLDHAQVNCTVAEDKVWTVVGHDHMR 642

  Fly  2855 ---IKMSSNSS------QMNDGEFHVVHLIKTGRKLELMVDDELQEIR---NLNGNPTVVSLPRD 2907
               |:.|:..|      ......:|:..|:.:....:..|....::.|   ..:|.|....|.||
Zfish   643 PIDIRGSTPRSPFVLIFNYTISPYHLRSLVTSSEHCQQEVIYRCRKSRLFDTWDGTPLSWWLDRD 707

  Fly  2908 AGGL---YIGGAPPHESYTPLAPTFVNLEGAIRDVVFNNRTINFN-DALTFANVQIGRNGPLMGS 2968
              |:   |.||..|     .:.....:|:|..||:   |...|.: |..|:||    ..|.|  |
Zfish   708 --GVKRTYWGGFLP-----GVQQCSCSLDGNCRDM---NYFCNCDADQDTWAN----DTGVL--S 756

  Fly  2969 LKGGLYDVLLKTEPMIGKSFTASPEGCKRIGSYSYEPNAFKFGDDIYSYSQLKLPERHFWQRNFH 3033
            .|    |.|..:|..||.:...:.:...:||......|.| |.:....|.:...  .||......
Zfish   757 YK----DHLPLSEIAIGDTNRTNSQAELQIGPLRCYGNRF-FWNSASFYQESSY--LHFPTLQAE 814

  Fly  3034 LSFDFRSFYP----NGMLYLSPGSKEKPKHYVALVLK------------DGQLVLVVRGRRREEL 3082
            ||.|...|:.    :|:...:.|.::    :|.|.|.            ||.:.|.||.
Zfish   815 LSIDISLFFKTSAFSGVFLENLGVRD----FVRLELSSPSTMNFTFDLGDGPVTLTVRS------ 869

  Fly  3083 QLTAKLNDGEWHRVTISCHDRKVTMSVEIGRTDQKTSAQMKLPKKIGASQLLLVGGLPQSPVKVS 3147
              ...|||.:||.:....:.::.::.|: ....:.|.|..:.|.::..|..|.|||...
Zfish   870 --PVALNDRQWHYIRAERNVKEASLQVD-SLPLELTEAPPEKPYRLQLSSQLFVGGTAS------ 925

  Fly  3148 SDLYVRLEPFKGCLRRVSINNNTQDL-----ARPGKHS-------------NVGQCFPTVERGSY 3194
                 |...|.||||.::||..|.||     ..||.:|             |.|:|  ..||.||
Zfish   926 -----RQRGFVGCLRALTINGVTLDLFERAKTTPGVNSGCPGHCTSDSVCHNGGRC--VEERSSY 983

  Fly  3195 --------FPGDAYAIYKKNFNVGKYLDLETEFRTSEL-------SGILLSVS--DPNGF----- 3237
                    |.|.         :..|.|....|..:|.|       ||||...:  .|.||
Zfish   984 ACDCTQTAFDGP---------HCRKALAASFESGSSVLYTLQEPFSGILNEEARRSPAGFHDAEV 1039

  Fly  3238 ----------------PALSLELH--NGNIIFSCDPGNGA---------PMRVESSLPTKYALCD 3275
                            |||.|..|  :.|.:......||:         ..|.|...|...:|.|
Zfish  1040 AKSQEKVSFGFLTRHVPALILMAHTLDQNYMAVMLTSNGSLQIRYLMNKEKRTEMFSPKSGSLAD 1104

  Fly  3276 NKWHNISALYDGEQIVLRIDQLPAVISVGNQGNA---------GKVQ----TRSPLYIGGLPESA 3327
            .::|.:.....|::::::||.........:.|:|         |::|    |...|...||
Zfish  1105 GRFHWVKINRKGQELLVQIDNTITQQYSLSPGSALSPVRSVILGRIQGSDITDKELVQAGL---- 1165

  Fly  3328 PSGSLISRENFKGCIRHV 3345
                    ..|.||:..|
Zfish  1166 --------RGFIGCLSSV 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	153..398	CDD:459653
		EGF_Lam	401..450	CDD:238012
		EGF_Lam	505..552	CDD:238012
		Laminin_EGF	550..597	CDD:395007
		Laminin_B	660..813	CDD:459652
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:395007
		Laminin_EGF	974..1018	CDD:395007
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:395007
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:395007
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:395007
		Laminin_EGF	1340..1392	CDD:395007
		Laminin_B	1486..1626	CDD:459652
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:395007
		EGF_Lam	1772..1819	CDD:238012
		YhaN	<1907..2141	CDD:443752
		SMC_prok_B	<2123..>2390	CDD:274008	44/235 (19%)
		Laminin_II	2279..2400	CDD:368703	19/133 (14%)
		LamG	2399..>2492	CDD:473984	22/101 (22%)
		LamG	2586..2753	CDD:238058	41/172 (24%)
		Laminin_G_2	2804..2944	CDD:460494	27/156 (17%)
		LamG	3018..3167	CDD:238058	36/164 (22%)
		LamG	3192..3347	CDD:238058	45/216 (21%)
cntnap5l	XP_001338473.5	FA58C	37..174	CDD:238014	37/166 (22%)
		Laminin_G_2	210..339	CDD:460494	31/157 (20%)
		Laminin_G_2	397..525	CDD:460494	36/144 (25%)
		EGF_CA	552..586	CDD:238011	7/33 (21%)
		LamG	799..940	CDD:238058	37/166 (22%)
		EGF_CA	964..997	CDD:238011	9/43 (21%)
		Laminin_G_2	1050..1178	CDD:460494	29/138 (21%)