DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wb and ntn1

DIOPT Version :9

Sequence 1:	NP_723870.1	Gene:	wb / 43946	FlyBaseID:	FBgn0261563	Length:	3375	Species:	Drosophila melanogaster
Sequence 2:	NP_001072385.1	Gene:	ntn1 / 779839	XenbaseID:	XB-GENE-989335	Length:	601	Species:	Xenopus tropicalis

Alignment Length:	671	Identity:	162/671 - (24%)
Similarity:	251/671 - (37%)	Gaps:	157/671 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 PPQRRRNGKLQKSGGGAGGGALRLLKTEDVYSSSFSGGLYPPLFNVVPRAQISVNATCGQNGAEE 179
            |..:..|.....:.||...|.....|....|       ..|...||....::..:.|||:. .::
Frog    21 PRGQENNSNKASTHGGTPDGPCYDAKQRPKY-------CIPDFINVALGQEVITSNTCGRT-PQK 77

  Fly   180 YC-----KQVGAKPCGICNAHSSDRAKQRSIQSLISSGSGSGSGSGFEEGWWQSPTLQGGRQF-E 238
            .|     ..|.::.|.:|:....:.:...|..:...:           :..|:|   :.|..| :
Frog    78 LCYFLDSTNVTSRRCQLCDQKRPENSYPPSYMTDTDA-----------QTCWKS---ESGITFPQ 128

  Fly   239 YVTILLDLKQTFQIFSVWLKSANSPRPASWILEKSLD-GINFEPWQYFGLSDADCQRRWNLSGQN 302
            .||:.|.|.:.|::....|:.. ||||.|..:.||:| |..:.|:|::   ...|:|
Frog   129 NVTLTLPLGRRFELVYASLRFC-SPRPDSMAIYKSMDYGKTWIPFQFY---STHCRR-------- 181

  Fly   303 GKYVFQNDTEIICSTQFSKP--------------GPLENGVLHASLLKNRPGAT--DQSPELMKF 351
               |:...|    ::..|||              .||..|::....|..||.|.  :.||.|..:
Frog   182 ---VYDQAT----TSAISKPMQHEATCTDFQTGVKPLTKGLVAFMPLAGRPSARRFEYSPVLQDW 239

  Fly   352 ITTRYIRIRLQGMHSTANQDNSLDWLLDSPSLEKHSFYSLSQLKVSARLDCNGHANRSHESPDDP 416
            :|...||:....:|......          ...|.:||.:|:::|..|..|||||:|.....:.
Frog   240 VTATDIRVVFNRLHHGKKMG----------IRRKTAFYGVSEIQVGGRCKCNGHASRCTAGKEG- 293

  Fly   417 LMQCICQHNTCGAQCEQCCPLFQDRPYQM-----GGECEICQCYGHAESCTYDPFLDK------- 469
             :.|.|||||.|.:|:.|.|.:.|||:|.     ..||..|:|..|:..|.::..|.|
Frog   294 -LMCECQHNTIGPECDACKPFYYDRPWQRATPSNAHECVACECNLHSHRCRFNMELYKLSGRKSG 357

  Fly   470 GICQSCSNNTAGIECEFCEMGFYRELDAPLTD--PCLPCSCNPARSTGG-CQSDGGSCNCLEGFQ 531
            |:|.:|.:||||..|.:|:.|:.|:|..|:|.  .|.||.|:|..:... |....|.|.|..|..
Frog   358 GVCLNCRHNTAGRHCHYCKQGYKRDLSKPITSRKACKPCQCHPIGAVNAMCNQTTGQCQCKTGVT 422

  Fly   532 GKNCEECAPGYYGDDCKRCECDERGSLGSTGSCSGVCQCKLNVEGSTC-SECAPGYFDLSAENAE 595
            |..|..|||||.........| .|.....|.:.|...:.|....|:.| |.|.|.:..:.....:
Frog   423 GPTCNRCAPGYQQSRSAHMPC-VRIQEEMTTTASYPQEWKAGTNGTECQSYCKPSHSRVHMNLRK 486

  Fly   596 GCTSCWCSGVSQTCHSAKLQTLAFETLNDWKITDIQRVKPISIPVDAETNRLIFANELDEVEAIY 660
            .|         :..:..:.|.|:.|...:|
Frog   487 YC---------KKDYVLRAQLLSMEKSGEW----------------------------------- 507

  Fly   661 WQASLGYLGNRLTSYGSRLQLVLSWDVIRGDRSGKPTTGPN--------VILVGKNGLKIAFGDE 717
            ||    :....||.|..|     ...:.|||   :|...|:        .:.|||:.|.|...:|
Frog   508 WQ----FTATVLTVYRQR-----RVPIRRGD---QPLWVPDHDLACDCLRVQVGKSYLIIGNDEE 560

  Fly   718 SLDGLGINLNVTLTEVGWYHV 738
            |.|...:.|:.....:.|..|
Frog   561 SPDPARLILDKNSLALPWRDV 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wb	NP_723870.1	Laminin_N	164..396	CDD:278484	54/254 (21%)
		EGF_Lam	401..450	CDD:238012	21/53 (40%)
		TNFRSF	<407..507	CDD:304602	39/113 (35%)
		EGF_Lam	505..552	CDD:238012	16/47 (34%)
		Laminin_EGF	550..597	CDD:278482	10/47 (21%)
		Laminin_B	660..798	CDD:278481	22/87 (25%)
		EGF_Lam	851..900	CDD:238012
		Laminin_EGF	<943..971	CDD:278482
		VSP	953..1414	CDD:146106
		Laminin_EGF	974..1018	CDD:278482
		EGF_Lam	1017..1065	CDD:238012
		Laminin_EGF	1065..>1105	CDD:278482
		EGF_Lam	1150..1197	CDD:238012
		Laminin_EGF	1199..1247	CDD:278482
		EGF_Lam	1247..1292	CDD:238012
		Laminin_EGF	1294..1342	CDD:278482
		Laminin_EGF	1340..1392	CDD:278482
		Laminin_B	1486..1611	CDD:278481
		EGF_Lam	1669..1716	CDD:238012
		Laminin_EGF	1718..1767	CDD:278482
		EGF_Lam	1772..1819	CDD:238012
		CrfC	<1933..2267	CDD:223771
		Laminin_II	2277..2400	CDD:283628
		LamG	2399..>2492	CDD:304605
		Laminin_G_2	2616..2755	CDD:280389
		Laminin_G_2	2804..2944	CDD:280389
		Laminin_G_2	3038..3169	CDD:280389
		LamG	3192..3347	CDD:238058
ntn1	NP_001072385.1	Laminin_N	61..276	CDD:365840	55/258 (21%)
		EGF_Lam	277..321	CDD:238012	20/45 (44%)
		EGF_CA	333..386	CDD:389777	18/52 (35%)
		EGF_Lam	395..444	CDD:238012	17/49 (35%)
		NTR_netrin-1_like	484..598	CDD:239634	27/154 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910